Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

2016 ◽  
Vol 28 ◽  
pp. 43-64 ◽  
Author(s):  
Shachar Raz ◽  
Michal Stark ◽  
Yehuda G. Assaraf
Keyword(s):  
Glutamate Synthetase ◽  
Folate Homeostasis ◽  
Antifolate Resistance

Mammalian folylpoly-.gamma.-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis

Biochemistry ◽  
1987 ◽  
Vol 26 (2) ◽  
pp. 530-539 ◽  
Author(s):  
Janine D. Cook ◽  
David J. Cichowicz ◽  
Sabu George ◽  
Ann Lawler ◽  
Barry Shane
Keyword(s):  
In Vivo Metabolism ◽  
Glutamate Synthetase ◽  
Folate Homeostasis

Effects of Antisense-based Folylpoly-γ-glutamate Synthetase Down-regulation on Reduced Folates and Cellular Proliferation in CCRF-CEM Cells

1998 ◽  
Vol 55 (12) ◽  
pp. 2031-2037 ◽  
Author(s):  
Yinong Liu ◽  
K Raghunathan ◽  
Charles Hill ◽  
Yunhua He ◽  
Marlene A Bunni ◽  
...  
Keyword(s):  
Cellular Proliferation ◽  
Down Regulation ◽  
Glutamate Synthetase

Folylpoly-γ-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity

1999 ◽  
Vol 39 (1) ◽  
pp. 263-273 ◽  
Author(s):  
Hong Qi ◽  
Ian Atkinson ◽  
Shan Xiao ◽  
Yun-Jung Choi ◽  
Takamasa Tobimatsu ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Glutamate Synthetase ◽  
One Carbon Metabolism

Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors

Parasitology ◽  
2005 ◽  
Vol 130 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Y. YUTHAVONG ◽  
J. YUVANIYAMA ◽  
P. CHITNUMSUB ◽  
J. VANICHTANANKUL ◽  
S. CHUSACULTANACHAI ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Structural Basis ◽  
Antifolate Resistance

Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance

2011 ◽  
Vol 6 (9) ◽  
pp. 905-911 ◽  
Author(s):  
Jarunee Vanichtanankul ◽  
Supannee Taweechai ◽  
Jirundon Yuvaniyama ◽  
Tirayut Vilaivan ◽  
Penchit Chitnumsub ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Antifolate Resistance
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