Mouse Folylpoly-γ-glutamate Synthetase Isoforms Respond Differently to Feedback Inhibition by Folylpolyglutamate Cofactors†

Biochemistry ◽  
2002 ◽  
Vol 41 (1) ◽  
pp. 226-235 ◽  
Author(s):  
John L. Andreassi ◽  
Richard G. Moran
Keyword(s):  
Feedback Inhibition ◽  
Glutamate Synthetase

scholarly journals Menaquinone-mediated regulation of membrane fluidity is relevant for fitness of Listeria monocytogenes

2021 ◽  
Author(s):  
Alexander Flegler ◽  
Vanessa Kombeitz ◽  
André Lipski
Keyword(s):  
Fatty Acid ◽  
Listeria Monocytogenes ◽  
Membrane Fluidity ◽  
Low Temperatures ◽  
Lipid Membrane ◽  
Feedback Inhibition ◽  
Aromatic Amino Acids ◽  
Adaptation Effect ◽  
Membrane Composition ◽  
Lower Growth

AbstractListeria monocytogenes is a food-borne pathogen with the ability to grow at low temperatures down to − 0.4 °C. Maintaining cytoplasmic membrane fluidity by changing the lipid membrane composition is important during growth at low temperatures. In Listeria monocytogenes, the dominant adaptation effect is the fluidization of the membrane by shortening of fatty acid chain length. In some strains, however, an additional response is the increase in menaquinone content during growth at low temperatures. The increase of this neutral lipid leads to fluidization of the membrane and thus represents a mechanism that is complementary to the fatty acid-mediated modification of membrane fluidity. This study demonstrated that the reduction of menaquinone content for Listeria monocytogenes strains resulted in significantly lower resistance to temperature stress and lower growth rates compared to unaffected control cultures after growth at 6 °C. Menaquinone content was reduced by supplementation with aromatic amino acids, which led to a feedback inhibition of the menaquinone synthesis. Menaquinone-reduced Listeria monocytogenes strains showed reduced bacterial cell fitness. This confirmed the adaptive function of menaquinones for growth at low temperatures of this pathogen.

scholarly journals Multivalent Feedback Inhibition of Aspartokinase in Bacillus polymyxa

1970 ◽  
Vol 245 (19) ◽  
pp. 4900-4906
Author(s):  
Chitra Biswas ◽  
Edith Gray ◽  
Henry Paulus
Keyword(s):  
Feedback Inhibition ◽  
Bacillus Polymyxa

Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition

Cell Cycle ◽  
2021 ◽  
pp. 1-12
Author(s):  
Jennifer P. Ditano ◽  
Nandini Sakurikar ◽  
Alan Eastman
Keyword(s):  
Feedback Inhibition ◽  
Cyclin A ◽  
Cdc25a Phosphatase
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