scholarly journals Hepatoprotective activity of Cichorium intybus (Linn.) root extract against carbon tetrachloride induced hepatotoxicity in albino Wistar rats

2013 ◽  
Vol 5 (4) ◽  
pp. 311-314 ◽  
Author(s):  
Bhaskara Reddy Nallamilli ◽  
Ch.S. Phani Kumar ◽  
K. Veer Reddy ◽  
M. Lakshmi Prasanna ◽  
V. Maruthi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Hepatoprotective Activity ◽  
Cichorium Intybus ◽  
Root Extract

COMPARATIVE EVALUATION OF IN VITRO ANTIOXIDANT AND IN VIVO HEPATOPROTECTIVE ACTIVITIES OF ETHANOLIC LEAF AND ROOT EXTRACTS OF CLEOME GYNANDRA

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (04) ◽  
pp. 50-56
Author(s):  
K Ravishankar ◽  
Y.V.V.M. Lakshmi Prasanna ◽  
G.V.N. Kiranmayi ◽  
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatoprotective Activity ◽  
Root Extract ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Root Extracts ◽  
Cleome Gynandra ◽  
Ic50 Values ◽  
Ethanolic Leaf Extract

In vitro antioxidant and in vivo hepatoprotective activities of Cleome gynandra ethanolic leaf and root extracts were assessed. In vitro antioxidant activity was carried by DPPH, Nitric oxide, hydroxyl radical and phosphomolybdenum assays. Hepatoprotective activity was evaluated by Carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats.The animals were divided into seven groups (Four test groups - Ethanolic Leaf and Root Extracts of Cleome gynandra of 100 mg/kg and 200 mg/kg, standard silymarin (100 mg/kg), toxic control-carbon tetrachloride and vehicle). On the eight day, the blood was collected and parameters like serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP) and Total bilirubin (TB) were estimated. Significant antioxidant status with good IC50 values similar to standard ascorbic acid was obtained. A significant decrease in liver enzymes was observed in test groups comparable to silymarin. From the results obtained, ethanolic leaf extract has contributed better hepatoprotection compared with root extract in experimental rats.

scholarly journals Protective Effect of the Mixture of Stem bark, Leaf and Root Extract of Bauhinia acuminata L. against Carbon tetrachloride induced Liver Damage in Wistar Albino Rats

2021 ◽  
Vol 01 (05) ◽  
Author(s):  
Venkatesh Sellamuthu ◽  
Keyword(s):  
Carbon Tetrachloride ◽  
Vitamin C ◽  
Stem Bark ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Standard Result ◽  
Soxhlet Apparatus ◽  
Study Results

Objective: The objective of the present study was to evaluate the hepatoprotective effect of mixture of stem bark, leaf and root extract of Bauhinia acuminata L. using carbon tetrachloride induced hepatotoxicity model. Method: Powdered mixture materials were extracted with distilled water using soxhlet apparatus. The dried extracts were subjected to preliminary phytochemical analysis and the extracts were evaluated for acute oral toxicity by OECD guidelines 423.The aqueous extract at a dose level 200 mg/kg and 400 mg/kg were selected and administered to albino rats for hepatoprotective screening. Hepatotoxicity was induced by Carbon tetrachloride (1 ml/kg with CMC). Silymarin (100 mg/kg p. o) was used as the standard. Result: The preliminary phytochemical examination showed the presence of Alkaloids, Glycosides, Saponins, Flavanoids, Tannins, Aminoacids, Tryptophan, Quinones, Terpinoids, Starch, Vitamin C and Carbohydrates. Furthermore, the acute toxicity study results showed that the extracts were found to be safe up to 2000 mg/kg b. wt. The extract dose dependently shows hepatoprotective potential by restoring the elevated biochemical parameters. Conclusion: The results obtained from the study indicates that mixture of stem bark, leaves and root extract of Bauhinia acuminata L. possess promising hepatoprotective activity. The activity might be due the presence of the phytoconstituents including Alkaloids, Glycosides, Saponins, Flavanoids, Tannins, Aminoacids, Carbohydrates Terpinoids, Starch, Vitamin C, Tryptophan and Quinones in the extract. Further studies are required to identify the active principle responsible for the hepatoprotective activity.

scholarly journals Study on hepatoprotective effect of root methanolic extract of Acanthus ilicifolius L. in carbon tetrachloride induced mice

2016 ◽  
Vol 14 (2) ◽  
pp. 253-259
Author(s):  
Phan Kim Định ◽  
Trương Đình Yến An ◽  
Trương Thị Thanh Trúc ◽  
Đái Thị Xuân Trang
Keyword(s):  
Carbon Tetrachloride ◽  
Methanol Extract ◽  
Hepatoprotective Activity ◽  
Positive Control ◽  
Steroid Glycoside ◽  
Root Extract ◽  
Hepatic Diseases ◽  
Acanthus Ilicifolius ◽  
Phytochemical Compounds ◽  
Hepatoprotective Effects

Acanthus ilicifolius is a common medicinal herb used in treatment for hepatic diseases in Vietnamese traditional medicine. This study investigated hepatoprotective effects of methanol extract of A.ilicifolius roots at various concentrations on mice having carbon tetrachloride (CCl4)-induced liver damages by measuring levels of two liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). Mice’s livers were injured by using CCl4 in olive oil, in the ratio of 1 to 4 with the dosing concentration of 0.2 ml per day in 4 consecutive weeks (or 8 consecutive weeks). After one hour taking CCl4 by oral administration, mice were treated with roots’ methanol extract at three different concentrations (15, 30, and 45 mg/kg BW). Silymarin, a commercial liver protector was used as a positive control. After 4 weeks of treatment, the AST levels decreased by 86.6%, 86.3%, 85.3% and ALT levels declined by 83.9%, 83.8%, 81.4%. After 8 weeks of treatment, the use of 30 mg/kg BW root extract showed the best hepatoprotective activity with the lowest levels of AST and ALT. Our result also indicated that the hepatoprotective effects of roots’ methanol extract of A.ilicifolius were similar to that of sylimarin (using at 16 mg/kg BW). The microscopic structure proved that the hepatocytes recovered significantly in mice treated with roots’ methanol extract of A.ilicifolius at dose 45 mg/kg BW. However, root extract of A.ilicifolius at dose of 15 and 30 mg/kg BW could not improved liver damages comparing to untreated mice. The qualitative analysis of phytochemical compounds showed that Acanthus ilicifolius root contains alkaloid, flavonoid, triterpenoid, steroid, glycoside, and phenol substances.

scholarly journals Effect of Chicory (Cichorium intybus L.) Root Extract on Some Blood Parameters of Broiler Chicks Under Carbon Tetrachloride-Induced Toxicity

2021 ◽  
Vol 52 (1) ◽  
pp. 47-53
Author(s):  
Aref Jahani ◽  
Mohammad Hassan Bozorgmehri-Fard ◽  
Seyyed Mohammad Mahdi Kiaei ◽  
Saeed Hesaraki ◽  
Nariman Sheikhi
Keyword(s):  
Carbon Tetrachloride ◽  
Blood Parameters ◽  
Cichorium Intybus ◽  
Broiler Chicks ◽  
Root Extract

scholarly journals Study The protective Effects of Cichorium intybus L. Root Extract Against Carbon Tetrachloride-Induced Hepatotoxicity in Broiler Chickens

2021 ◽  
Vol 52 (1) ◽  
pp. 23-30
Author(s):  
Aref Jahani ◽  
Mohammad Hassan Bozorgmehri-Fard ◽  
Seyyed Mohammad Mahdi Kiaei ◽  
Saeid Hesaraki ◽  
Nariman Sheikhi
Keyword(s):  
Carbon Tetrachloride ◽  
Broiler Chickens ◽  
Cichorium Intybus ◽  
Root Extract ◽  
Protective Effects
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