AGS3 is involved in TNF-α medicated osteogenic differentiation of human dental pulp stem cells

2015 ◽  
Vol 89 (5) ◽  
pp. 128-136 ◽  
Author(s):  
Jing Xing ◽  
Min Lian ◽  
Qijie Shen ◽  
Guijuan Feng ◽  
Dan Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Tnf Α ◽  
Human Dental Pulp

High dose of TNF-α suppressed osteogenic differentiation of human dental pulp stem cells by activating the Wnt/β-catenin signaling

2015 ◽  
Vol 46 (4-5) ◽  
pp. 409-420 ◽  
Author(s):  
Zhenjie Qin ◽  
Zhixiu Fang ◽  
Lei Zhao ◽  
Jing Chen ◽  
Yuanteng Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
High Dose ◽  
Tnf Α ◽  
Human Dental Pulp

TNF-α triggers osteogenic differentiation of human dental pulp stem cells via the NF-κB signalling pathway

2013 ◽  
Vol 37 (12) ◽  
pp. 1267-1275 ◽  
Author(s):  
Xingmei Feng ◽  
Guijuan Feng ◽  
Jing Xing ◽  
Biyu Shen ◽  
Liren Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Signalling Pathway ◽  
Tnf Α ◽  
Human Dental Pulp

Chrysin induces osteogenic differentiation of human dental pulp stem cells

2021 ◽  
Vol 400 (2) ◽  
pp. 112466
Author(s):  
J.F. Huo ◽  
M.L. Zhang ◽  
X.X. Wang ◽  
D.H. Zou
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp

MiR-21/STAT3 Signal Is Involved in Odontoblast Differentiation of Human Dental Pulp Stem Cells Mediated by TNF-α

2018 ◽  
Vol 20 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Ke Xu ◽  
Jingwen Xiao ◽  
Ke Zheng ◽  
Xingmei Feng ◽  
Jinlong Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Odontoblast Differentiation ◽  
Tnf Α ◽  
Human Dental Pulp

scholarly journals Functionalization of Polycaprolactone Scaffolds with Hyaluronic Acid and β-TCP Facilitates Migration and Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro

2015 ◽  
Vol 21 (3-4) ◽  
pp. 729-739 ◽  
Author(s):  
Jonas Jensen ◽  
David Christian Evar Kraft ◽  
Helle Lysdahl ◽  
Casper Bindzus Foldager ◽  
Muwan Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hyaluronic Acid ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp

Berberine Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Activating EGFR-MAPK-Runx2 Pathways

2019 ◽  
Vol 26 (3) ◽  
pp. 1677-1685 ◽  
Author(s):  
Bing-Chang Xin ◽  
Qi-Shan Wu ◽  
Song Jin ◽  
Ai-Hua Luo ◽  
De-Gang Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp

scholarly journals Exosomal circLPAR1 Promoted Osteogenic Differentiation of Homotypic Dental Pulp Stem Cells by Competitively Binding to hsa-miR-31

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Liangkun Xie ◽  
Zheng Guan ◽  
Mingzhu Zhang ◽  
Sha Lyu ◽  
Nattawut Thuaksuban ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Expression Profiles ◽  
Circular Rna ◽  
Inhibitory Effect ◽  
Dental Pulp Stem Cells ◽  
Great Promise ◽  
Human Dental Pulp ◽  
Osteogenic Induction

Human dental pulp stem cells (DPSCs) hold great promise in bone regeneration. However, the exact mechanism of osteogenic differentiation of DPSCs remains unknown, especially the role of exosomes played in. The DPSCs were cultured and received osteogenic induction; then, exosomes from osteogenic-induced DPSCs (OI-DPSC-Ex) at different time intervals were isolated and sequenced for circular RNA (circRNA) expression profiles. Gradually, increased circular lysophosphatidic acid receptor 1 (circLPAR1) expression was found in the OI-DPSC-Ex coincidentally with the degree of osteogenic differentiation. Meanwhile, results from osteogenic differentiation examinations showed that the OI-DPSC-Ex had osteogenic effect on the recipient homotypic DPSCs. To investigate the mechanism of exosomal circLPAR1 on osteogenic differentiation, we verified that circLPAR1 could competently bind to hsa-miR-31, by eliminating the inhibitory effect of hsa-miR-31 on osteogenesis, therefore promoting osteogenic differentiation of the recipient homotypic DPSCs. Our study showed that exosomal circRNA played an important role in osteogenic differentiation of DPSCs and provided a novel way of utilization of exosomes for the treatment of bone deficiencies.

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