scholarly journals Novel roles of Pkd2 in male reproductive system development

2014 ◽  
Vol 87 (3-4) ◽  
pp. 161-171 ◽  
Author(s):  
Xuguang Nie ◽  
Lois J. Arend
Keyword(s):  
Reproductive System ◽  
System Development ◽  
Male Reproductive System

Temperature stress interferes with male reproductive system development in clementine ( Citrus clementina Hort. ex. Tan.)

2019 ◽  
Vol 175 (1) ◽  
pp. 29-41
Author(s):  
Stefania Bennici ◽  
Gaetano Distefano ◽  
Giuseppina Las Casas ◽  
Mario Di Guardo ◽  
Giuseppe Lana ◽  
...  
Keyword(s):  
Temperature Stress ◽  
Reproductive System ◽  
System Development ◽  
Male Reproductive System ◽  
Citrus Clementina

Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels

2019 ◽  
Vol 87 ◽  
pp. 146-155 ◽  
Author(s):  
Birce Sunman ◽  
Kadriye Yurdakök ◽  
Belma Kocer-Gumusel ◽  
Özgür Özyüncü ◽  
Filiz Akbıyık ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bisphenol A ◽  
Cord Blood ◽  
Reproductive System ◽  
System Development ◽  
Sex Hormone ◽  
Male Reproductive System ◽  
Hormone Levels ◽  
Phthalate Exposure

Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study

2020 ◽  
Vol 95 ◽  
pp. 11-18
Author(s):  
Rodrigo L.P. Romao ◽  
Linda Dodds ◽  
Jillian Ashley-Martin ◽  
Patricia Monnier ◽  
Tye E. Arbuckle
Keyword(s):  
Cohort Study ◽  
Prenatal Exposure ◽  
Reproductive System ◽  
System Development ◽  
Male Reproductive System ◽  
Pregnancy Cohort

scholarly journals Investigation of the lncRNA THOR in Mice Highlights the Importance of Noncoding RNAs in Mammalian Male Reproduction

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 859
Author(s):  
Lin Zhou ◽  
Jianing Li ◽  
Jinsong Liu ◽  
Anbei Wang ◽  
Ying Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Reproductive System ◽  
Noncoding Rna ◽  
System Development ◽  
Male Reproductive System ◽  
Male Reproduction ◽  
Erk Signaling ◽  
Mrna Levels ◽  
Male Mice ◽  
Human Reproductive

THOR is a highly conserved testis-specific long noncoding RNA (lncRNA). The interaction between THOR and the development of the male reproductive system remains unclear. Herein, CRISPR/Cas9 technology was used to establish a stable THOR-deficient mouse model, and the relationship between THOR and the fertility of adult male mice was investigated. The male mice in which THOR was deleted were smaller than the WT male mice. Moreover, their survival rate was reduced by 60%, their fertility was reduced by 50%, their testicular size and sperm motility were reduced by 50%, their testicular cell apoptosis was increased by 7-fold, and their ratio of female-to-male offspring was imbalanced (approximately 1:3). Furthermore, to elucidate the mechanisms of male reproductive system development, the mRNA levels of THOR targets were measured by qRT-PCR. Compared with WT mice, the THOR-deficient mice exhibited significantly decreased mRNA levels of IGF2BP1, c-MYC, IGF1, and IGF2. MEK-ERK signaling pathway expression was downregulated as determined by Western blot. We found that THOR targeted the MER-ERK signaling pathway downstream of IGF2 by binding to IGF2BP1 and affected testicular and sperm development in male mice. These results may also provide perspectives for exploring the roles of lncRNAs in human reproductive development and the pathogenesis and potential therapeutic targets of infertility.

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