Cellular decisions in cardiac outflow tract and coronary development: An act by VEGF and NOTCH

2012 ◽  
Vol 84 (1) ◽  
pp. 62-78 ◽  
Author(s):  
Nynke M.S. van den Akker ◽  
Vincenza Caolo ◽  
Daniël G.M. Molin
Keyword(s):  
Outflow Tract ◽  
Cardiac Outflow

Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract

2008 ◽  
Vol 8 (6) ◽  
pp. 471-476 ◽  
Author(s):  
Lars Wittler ◽  
Michael Saborowski ◽  
Michael Kessel
Keyword(s):  
Outflow Tract ◽  
Cardiac Outflow

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

Nature ◽  
1996 ◽  
Vol 380 (6576) ◽  
pp. 711-714 ◽  
Author(s):  
Marco W. Schilham ◽  
Mariëtte A. Oosterwegel ◽  
Petra Moerer ◽  
Jing Ya ◽  
Piet A. J. de Boer ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Outflow Tract ◽  
Cardiac Outflow

scholarly journals Prickle1mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

Biology Open ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 323-335 ◽  
Author(s):  
Brian C. Gibbs ◽  
Rama Rao Damerla ◽  
Eszter K. Vladar ◽  
Bishwanath Chatterjee ◽  
Yong Wan ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Polarity ◽  
Birth Defects ◽  
Planar Cell Polarity ◽  
Outflow Tract ◽  
Directional Cell Migration ◽  
Cardiac Outflow

Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant

Development ◽  
1997 ◽  
Vol 124 (2) ◽  
pp. 505-514 ◽  
Author(s):  
S.J. Conway ◽  
D.J. Henderson ◽  
A.J. Copp
Keyword(s):  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Outflow Tract ◽  
Avian Embryo ◽  
Cardiac Neural Crest ◽  
Branchial Arches ◽  
Aortic Arches ◽  
Cardiac Outflow

Neural crest cells originating in the occipital region of the avian embryo are known to play a vital role in formation of the septum of the cardiac outflow tract and to contribute cells to the aortic arches, thymus, thyroid and parathyroids. This ‘cardiac’ neural crest sub-population is assumed to exist in mammals, but without direct evidence. In this paper we demonstrate, using RT-PCR and in situ hybridisation, that Pax3 expression can serve as a marker of cardiac neural crest cells in the mouse embryo. Cells of this lineage were traced from the occipital neural tube, via branchial arches 3, 4 and 6, into the aortic sac and aorto-pulmonary outflow tract. Confirmation that these Pax3-positive cells are indeed cardiac neural crest is provided by experiments in which hearts were deprived of a source of colonising neural crest, by organ culture in vitro, with consequent lack of up-regulation of Pax3. Occipital neural crest cell outgrowths in vitro were also shown to express Pax3. Mutation of Pax3, as occurs in the splotch (Sp2H) mouse, results in development of conotruncal heart defects including persistent truncus arteriosus. Homozygotes also exhibit defects of the aortic arches, thymus, thyroid and parathyroids. Pax3-positive neural crest cells were found to emigrate from the occipital neural tube of Sp2H/Sp2H embryos in a relatively normal fashion, but there was a marked deficiency or absence of neural crest cells traversing branchial arches 3, 4 and 6, and entering the cardiac outflow tract. This decreased expression of Pax3 in Sp2H/Sp2H embryos was not due to down-regulation of Pax3 in neural crest cells, as use of independent neural crest markers, Hoxa-3, CrabpI, Prx1, Prx2 and c-met also revealed a deficiency of migrating cardiac neural crest cells in homozygous embryos. This work demonstrates the essential role of the cardiac neural crest in formation of the heart and great vessels in the mouse and, furthermore, shows that Pax3 function is required for the cardiac neural crest to complete its migration to the developing heart.

scholarly journals Notch and cardiac outflow tract development

2010 ◽  
Vol 1188 (1) ◽  
pp. 184-190 ◽  
Author(s):  
Rajan Jain ◽  
Stacey Rentschler ◽  
Jonathan A. Epstein
Keyword(s):  
Outflow Tract ◽  
Cardiac Outflow
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