scholarly journals Data describing the flow-mediated vasodilation responses and blood pressure in young adult humans after a single dose of oral edible emu oil

Data in Brief ◽  
2018 ◽  
Vol 17 ◽  
pp. 631-637
Author(s):  
Tadayoshi Miyashita ◽  
Ryosuke Koizumi ◽  
Yoshimasa Sagane ◽  
Koichi Niwa ◽  
Toshihiro Watanabe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Dose ◽  
Young Adult ◽  
Emu Oil ◽  
Adult Humans ◽  
Flow Mediated Vasodilation

scholarly journals Data on a single oral dose of camu camu (Myrciaria dubia) pericarp extract on flow-mediated vasodilation and blood pressure in young adult humans

Data in Brief ◽  
2018 ◽  
Vol 16 ◽  
pp. 993-999 ◽  
Author(s):  
Tadayoshi Miyashita ◽  
Ryosuke Koizumi ◽  
Takao Myoda ◽  
Yoshimasa Sagane ◽  
Koichi Niwa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adult ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Myrciaria Dubia ◽  
Adult Humans ◽  
Flow Mediated Vasodilation

scholarly journals Hypertension in Prenatally Undernourished Young-Adult Rats Is Maintained by Tonic Reciprocal Paraventricular–Coerulear Excitatory Interactions

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3568
Author(s):  
Bernardita Cayupe ◽  
Carlos Morgan ◽  
Gustavo Puentes ◽  
Luis Valladares ◽  
Héctor Burgos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Young Adult ◽  
Binding Sites ◽  
Systolic Pressure ◽  
Adult Rats ◽  
Excitatory Pathways ◽  
Induced Hypertension ◽  
Prenatal Undernutrition ◽  
Number Of Cells

Prenatally malnourished rats develop hypertension in adulthood, in part through increased α1-adrenoceptor-mediated outflow from the paraventricular nucleus (PVN) to the sympathetic system. We studied whether both α1-adrenoceptor-mediated noradrenergic excitatory pathways from the locus coeruleus (LC) to the PVN and their reciprocal excitatory CRFergic connections contribute to prenatal undernutrition-induced hypertension. For that purpose, we microinjected either α1-adrenoceptor or CRH receptor agonists and/or antagonists in the PVN or the LC, respectively. We also determined the α1-adrenoceptor density in whole hypothalamus and the expression levels of α1A-adrenoceptor mRNA in the PVN. The results showed that: (i) agonists microinjection increased systolic blood pressure and heart rate in normotensive eutrophic rats, but not in prenatally malnourished subjects; (ii) antagonists microinjection reduced hypertension and tachycardia in undernourished rats, but not in eutrophic controls; (iii) in undernourished animals, antagonist administration to one nuclei allowed the agonists recover full efficacy in the complementary nucleus, inducing hypertension and tachycardia; (iv) early undernutrition did not modify the number of α1-adrenoceptor binding sites in hypothalamus, but reduced the number of cells expressing α1A-adrenoceptor mRNA in the PVN. These results support the hypothesis that systolic pressure and heart rate are increased by tonic reciprocal paraventricular–coerulear excitatory interactions in prenatally undernourished young-adult rats.

Salivary Myeloperoxidase of Young Adult Humans

1984 ◽  
Vol 175 (4) ◽  
pp. 468-475 ◽  
Author(s):  
Q. T. Smith ◽  
C. H. Yang
Keyword(s):  
Young Adult ◽  
Adult Humans

A Single-Dose Bioequivalence and Food Effect Study With Aprepitant and Fosaprepitant Dimeglumine in Healthy Young Adult Subjects

2012 ◽  
Vol 1 (3) ◽  
pp. 93-101 ◽  
Author(s):  
C. R. Shadle ◽  
M. G. Murphy ◽  
Y. Liu ◽  
M. Ho ◽  
D. Tatosian ◽  
...  
Keyword(s):  
Single Dose ◽  
Young Adult ◽  
Food Effect ◽  
Effect Study ◽  
Healthy Young Adult

scholarly journals Blood pressure variability is independent of systolic pressure in adolescent and young adult patients undergoing hemodialysis

2018 ◽  
Vol 83 (3) ◽  
pp. 615-621 ◽  
Author(s):  
Jingjing Da ◽  
Zulong Zhang ◽  
Yan Shen ◽  
Qian Li ◽  
Ying Hu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adult ◽  
Blood Pressure Variability ◽  
Systolic Pressure ◽  
Adult Patients ◽  
Adolescent And Young Adult

scholarly journals β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Catherina A. Cuevas ◽  
Cheril Tapia-Rojas ◽  
Carlos Cespedes ◽  
Nibaldo C. Inestrosa ◽  
Carlos P. Vio
Keyword(s):  
Blood Pressure ◽  
Signal Transduction ◽  
Single Dose ◽  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Target Genes ◽  
Hypertensive Rats ◽  
Collagen Types ◽  
Dependent Signaling Pathway ◽  
Pyrvinium Pamoate

The mechanism of hypertension-induced renal fibrosis is not well understood, although it is established that high levels of angiotensin II contribute to the effect. Sinceβ-catenin signal transduction participates in fibrotic processes, we evaluated the contribution ofβ-catenin-dependent signaling pathway in hypertension-induced renal fibrosis. Two-kidney one-clip (2K1C) hypertensive rats were treated with lisinopril (10 mg/kg/day for four weeks) or with pyrvinium pamoate (Wnt signaling inhibitor, single dose of 60 ug/kg, every 3 days for 2 weeks). The treatment with lisinopril reduced the systolic blood pressure from 220 ± 4 in 2K1C rats to 112 ± 5 mmHg (P<0.05), whereas the reduction in blood pressure with pyrvinium pamoate was not significant (212 ± 6 in 2K1C rats to 170 ± 3 mmHg,P>0.05). The levels of collagen types I and III, osteopontin, and fibronectin decreased in the unclipped kidney in both treatments compared with 2K1C rats. The expressions ofβ-catenin, p-Ser9-GSK-3beta, and theβ-catenin target genes cyclin D1, c-myc, and bcl-2 significantly decreased in unclipped kidney in both treatments (P<0.05). In this study we provided evidence thatβ-catenin-dependent signaling pathway participates in the renal fibrosis induced in 2K1C rats.

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