scholarly journals High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b

2019 ◽  
Vol 49 (4) ◽  
pp. 590-604.e9 ◽  
Author(s):  
Takuya Ooki ◽  
Naoko Murata-Kamiya ◽  
Atsushi Takahashi-Kanemitsu ◽  
Weida Wu ◽  
Masanori Hatakeyama
1992 ◽  
Vol 12 (2) ◽  
pp. 135-141 ◽  
Author(s):  
S. Leoni ◽  
S. Spagnuolo ◽  
M. Massimi ◽  
F. Terenzi ◽  
L. Conti Devirgiliis

Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-dependent growth inhibition, probably mediated by molecules present on adult hepatocyte membranes, provoked the decrease of amino acid uptake only in the adult cells. The results indicate that the different modulation of amino acid transport by cell growth is dependent on the age and the differentiation stage of hepatocytes.


Nature ◽  
1974 ◽  
Vol 250 (5469) ◽  
pp. 739-741 ◽  
Author(s):  
IIH-NAN CHOU ◽  
PAUL H. BLACK ◽  
RICHARD O. ROBLIN

1979 ◽  
Vol 34 (3-4) ◽  
pp. 279-283 ◽  
Author(s):  
Jürgen van der Bosch ◽  
Ilse Sommer ◽  
Heinz Maier ◽  
Willy Rahmig

Abstract Lowered extracellular [Ca2+] causes low growth rates and low stationary cell densities in 3T3 cell cultures as compared to physiological [Ca2+]. Under otherwise constant conditions the extra­ cellular [Ca2+] determines a stable stationary cell density, which can be readied by increase of net cell number or decrease of net cell number, depending on cell density at the time of [Ca2+] adjustment. SV40-3T3 cells do not show this [Ca2+] dependency. At 39 °C 3T3 and SV40-3T3 cell populations show an increased growth rate at low cell densities as compared to cell populations at 35 °C. Approaching the stationary density the growth rate of both cell sorts is reduced faster at 39 °C than at 35 °C, leading to lower stationary cell densities at 39 °C than at 35 °C. A temperature change from 39 °C to 35 °C or in the opposite direction can affect the stationary cell density of 3T3 cell populations only if applied before reduction of growth rate by density-dependent growth-inhibiting principles has taken place.


AIChE Journal ◽  
2010 ◽  
Vol 57 (3) ◽  
pp. 765-771 ◽  
Author(s):  
Elvis J. Hernández ◽  
Guillermo Reglero ◽  
Tiziana Fornari

1977 ◽  
Vol 129 (2) ◽  
pp. 770-777 ◽  
Author(s):  
E Rosenberg ◽  
K H Keller ◽  
M Dworkin

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0165358 ◽  
Author(s):  
Núria Rovira-Graells ◽  
Sara Aguilera-Simón ◽  
Elisabet Tintó-Font ◽  
Alfred Cortés

Nature ◽  
1970 ◽  
Vol 227 (5260) ◽  
pp. 843-845 ◽  
Author(s):  
B. M. SEFTON ◽  
H. RUBIN

1974 ◽  
Vol 249 (11) ◽  
pp. 3483-3488
Author(s):  
Nancy Lewis Baenziger ◽  
Christa H. Jacobi ◽  
Robert E. Thach

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