scholarly journals Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

2011 ◽  
Vol 20 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Kazu Kikuchi ◽  
Jennifer E. Holdway ◽  
Robert J. Major ◽  
Nicola Blum ◽  
Randall D. Dahn ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acid Production ◽  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration

Cell ◽  
2006 ◽  
Vol 127 (3) ◽  
pp. 607-619 ◽  
Author(s):  
Alexandra Lepilina ◽  
Ashley N. Coon ◽  
Kazu Kikuchi ◽  
Jennifer E. Holdway ◽  
Richard W. Roberts ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Activity ◽  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration

2013 ◽  
Vol 110 (33) ◽  
pp. 13416-13421 ◽  
Author(s):  
Y. Fang ◽  
V. Gupta ◽  
R. Karra ◽  
J. E. Holdway ◽  
K. Kikuchi ◽  
...  
Keyword(s):  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

2019 ◽  
Vol 6 (2) ◽  
pp. 16 ◽  
Author(s):  
Suneeta Narumanchi ◽  
Karri Kalervo ◽  
Sanni Perttunen ◽  
Hong Wang ◽  
Katariina Immonen ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Cardiac Regeneration ◽  
Nuclear Antigen ◽  
Heart Regeneration ◽  
Adult Zebrafish ◽  
Tissue Samples ◽  
Micro Rnas ◽  
Proliferating Cell ◽  
Zebrafish Heart

The let-7c family of micro-RNAs (miRNAs) is expressed during embryonic development and plays an important role in cell differentiation. We have investigated the role of let-7c in heart regeneration after injury in adult zebrafish. let-7c antagomir or scramble injections were given at one day after cryoinjury (1 dpi). Tissue samples were collected at 7 dpi, 14 dpi and 28 dpi and cardiac function was assessed before cryoinjury, 1 dpi, 7 dpi, 14 dpi and 28 dpi. Inhibition of let-7c increased the rate of fibrinolysis, increased the number of proliferating cell nuclear antigen (PCNA) positive cardiomyocytes at 7 dpi and increased the expression of the epicardial marker raldh2 at 7 dpi. Additionally, cardiac function measured with echocardiography recovered slightly more rapidly after inhibition of let-7c. These results reveal a beneficial role of let-7c inhibition in adult zebrafish heart regeneration.

Abstract 706: Changes in Translational Efficacy During Zebrafish Heart Regeneration

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Joseph A Goldman ◽  
Ariel Bazzini ◽  
Antonio Giraldez ◽  
Kenneth Poss
Keyword(s):  
Heart Regeneration ◽  
Zebrafish Heart

scholarly journals In vivo cardiac reprogramming contributes to zebrafish heart regeneration

Nature ◽  
2013 ◽  
Vol 498 (7455) ◽  
pp. 497-501 ◽  
Author(s):  
Ruilin Zhang ◽  
Peidong Han ◽  
Hongbo Yang ◽  
Kunfu Ouyang ◽  
Derek Lee ◽  
...  
Keyword(s):  
Heart Regeneration ◽  
Zebrafish Heart

Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations

2015 ◽  
Vol 309 (8) ◽  
pp. H1237-H1250 ◽  
Author(s):  
Marina Leone ◽  
Ajit Magadum ◽  
Felix B. Engel
Keyword(s):  
Cardiac Function ◽  
Molecular Mechanisms ◽  
Cardiac Development ◽  
Cardiac Regeneration ◽  
Experimental Medicine ◽  
Heart Regeneration ◽  
Cardiomyocyte Proliferation ◽  
Naturally Occurring ◽  
Ability To Regenerate ◽  
Zebrafish Heart

The newt and the zebrafish have the ability to regenerate many of their tissues and organs including the heart. Thus, a major goal in experimental medicine is to elucidate the molecular mechanisms underlying the regenerative capacity of these species. A wide variety of experiments have demonstrated that naturally occurring heart regeneration relies on cardiomyocyte proliferation. Thus, major efforts have been invested to induce proliferation of mammalian cardiomyocytes in order to improve cardiac function after injury or to protect the heart from further functional deterioration. In this review, we describe and analyze methods currently used to evaluate cardiomyocyte proliferation. In addition, we summarize the literature on naturally occurring heart regeneration. Our analysis highlights that newt and zebrafish heart regeneration relies on factors that are also utilized in cardiomyocyte proliferation during mammalian fetal development. Most of these factors have, however, failed to induce adult mammalian cardiomyocyte proliferation. Finally, our analysis of mammalian neonatal heart regeneration indicates experiments that could resolve conflicting results in the literature, such as binucleation assays and clonal analysis. Collectively, cardiac regeneration based on cardiomyocyte proliferation is a promising approach for improving adult human cardiac function after injury, but it is important to elucidate the mechanisms arresting mammalian cardiomyocyte proliferation after birth and to utilize better assays to determine formation of new muscle mass.

89 The role of macrophages in embryonic zebrafish heart regeneration

2018 ◽  
Author(s):  
Finn Bruton ◽  
Aryan Baghbadrani ◽  
Charlotte Buckley ◽  
Carl Tucker ◽  
Martin Denvir ◽  
...  
Keyword(s):  
Heart Regeneration ◽  
Zebrafish Heart
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