scholarly journals A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration

Cell ◽  
2006 ◽  
Vol 127 (3) ◽  
pp. 607-619 ◽  
Author(s):  
Alexandra Lepilina ◽  
Ashley N. Coon ◽  
Kazu Kikuchi ◽  
Jennifer E. Holdway ◽  
Richard W. Roberts ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Activity ◽  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration

2013 ◽  
Vol 110 (33) ◽  
pp. 13416-13421 ◽  
Author(s):  
Y. Fang ◽  
V. Gupta ◽  
R. Karra ◽  
J. E. Holdway ◽  
K. Kikuchi ◽  
...  
Keyword(s):  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

2011 ◽  
Vol 20 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Kazu Kikuchi ◽  
Jennifer E. Holdway ◽  
Robert J. Major ◽  
Nicola Blum ◽  
Randall D. Dahn ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acid Production ◽  
Heart Regeneration ◽  
Injury Response ◽  
Zebrafish Heart

scholarly journals Inhibition of let-7c Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish

2019 ◽  
Vol 6 (2) ◽  
pp. 16 ◽  
Author(s):  
Suneeta Narumanchi ◽  
Karri Kalervo ◽  
Sanni Perttunen ◽  
Hong Wang ◽  
Katariina Immonen ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Cardiac Regeneration ◽  
Nuclear Antigen ◽  
Heart Regeneration ◽  
Adult Zebrafish ◽  
Tissue Samples ◽  
Micro Rnas ◽  
Proliferating Cell ◽  
Zebrafish Heart

The let-7c family of micro-RNAs (miRNAs) is expressed during embryonic development and plays an important role in cell differentiation. We have investigated the role of let-7c in heart regeneration after injury in adult zebrafish. let-7c antagomir or scramble injections were given at one day after cryoinjury (1 dpi). Tissue samples were collected at 7 dpi, 14 dpi and 28 dpi and cardiac function was assessed before cryoinjury, 1 dpi, 7 dpi, 14 dpi and 28 dpi. Inhibition of let-7c increased the rate of fibrinolysis, increased the number of proliferating cell nuclear antigen (PCNA) positive cardiomyocytes at 7 dpi and increased the expression of the epicardial marker raldh2 at 7 dpi. Additionally, cardiac function measured with echocardiography recovered slightly more rapidly after inhibition of let-7c. These results reveal a beneficial role of let-7c inhibition in adult zebrafish heart regeneration.

scholarly journals Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival

2019 ◽  
Vol 32 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Manisha N. Chandwani ◽  
Patrick S. Creisher ◽  
Lauren A. O'Donnell
Keyword(s):  
Progenitor Cell ◽  
Cell Activity ◽  
Cytokines And Chemokines

scholarly journals Nfatc1’s Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal

2021 ◽  
Author(s):  
Melissa McNeil ◽  
Yingying Han ◽  
Peng Sun ◽  
Kazuhide Watanabe ◽  
Jun Jiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mammary Gland ◽  
Progenitor Cell ◽  
Cell Function ◽  
Cell Activity ◽  
Basal Layer ◽  
Mammary Epithelial ◽  
Epithelial Morphogenesis ◽  
Small Subset ◽  
Self Renewal

AbstractMammary gland is an outstanding system to study the regulatory mechanisms governing adult epithelial stem cell activity. Stem cells in the basal layer of the mammary gland fuel the morphogenesis and regeneration of a complex epithelial network during development and upon transplantation. The self-renewal of basal stem/progenitor cells is subjected to regulation by both cell-intrinsic and extrinsic mechanisms. Nfatc1 is a transcription factor that regulates breast tumorigenesis and metastasis, but its role in mammary epithelial development and stem cell function has not been investigated. Here we show that Nfatc1 is expressed in a small subset of mammary basal epithelial cells and its epithelial-specific deletion results in mild defects in side branching and basal-luminal cell balance. Moreover, Nfatc1-deficient basal cells exhibit reduced colony forming ability in vitro and somewhat compromised regenerative potential upon transplantation. Thus, our study provides evidence for a detectable yet non-essential role of Nfatc1 in mammary epithelial morphogenesis and basal stem/progenitor cell self-renewal.

scholarly journals Monoamine Oxidase Deficiency Causes Prostate Atrophy and Reduces Prostate Progenitor Cell Activity

Stem Cells ◽  
2018 ◽  
Vol 36 (8) ◽  
pp. 1249-1258 ◽  
Author(s):  
Lijuan Yin ◽  
Jingjing Li ◽  
Chun-Peng Liao ◽  
Boyang Jason Wu
Keyword(s):  
Monoamine Oxidase ◽  
Progenitor Cell ◽  
Cell Activity ◽  
Oxidase Deficiency
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