scholarly journals Interactions between human microbiome, diet, enteric viruses and immune system: Novel insights from gnotobiotic pig research

2018 ◽  
Vol 28 ◽  
pp. 95-103
Author(s):  
Anastasia N. Vlasova ◽  
Gireesh Rajashekara ◽  
Linda J. Saif
Keyword(s):  
Immune System ◽  
Human Microbiome ◽  
Enteric Viruses ◽  
Gnotobiotic Pig

scholarly journals A praenatalis és postnatalis mikrobiom jelentősége és hatásai a korai egyedfejlődés időszakában és az intervenciós kezelés lehetőségei

2021 ◽  
Vol 162 (19) ◽  
pp. 731-740
Author(s):  
Vilmos Fülöp ◽  
János Demeter ◽  
Áron Cseh
Keyword(s):  
Immune System ◽  
Human Body ◽  
Functional Gastrointestinal Disorders ◽  
Intestinal Flora ◽  
Human Microbiome ◽  
Intestinal Barrier ◽  
Autism Spectrum ◽  
Gastrointestinal Disorders ◽  
Nutrient Metabolism ◽  
Health Maintenance

Összefoglaló. A humán mikrobiom az emberi szervezetben és az emberi testfelszínen élő mikrobaközösségek összessége, amelyek többsége a gyomor-bél rendszerben él. Ezek a mikrobaközösségek számos és sokféle baktériumot tartalmaznak, gombákat, vírusokat, archeákat és protozoonokat. Ez a mikrobiális közösség, vagy mikrobiota, a gazdaszervezetben nagyrészt egymással kölcsönösségi viszonyban tenyészik, és gondoskodik a bélben a tápanyagok anyagcseréjéről, kalibrálja az anyagcsere-működést, tanítja az immunrendszert, fenntartja a közösség integritását, és véd a kórokozók ellen. A majdan megszületendő magzat a megfelelő tápanyagellátását az anyai véráramból kapja, és így az anyai szervezetben a mikrobiota indukálta baktériumkomponensek vagy metabolitok hatékonyan átvihetők a magzatba. Az anyai mikrobiális közösségek – ideértve a praenatalis bélrendszeri, hüvelyi, száj- és bőrmikrobiomot – a terhesség alatt valójában kifejezett változásokon mennek keresztül, amelyek befolyásolhatják az egészség megőrzését, és hozzájárulhatnak a közismert betegségek kialakulásához. A magzat nem steril, és immunológiai szempontból sem naiv, hanem az anya révén környezeti ingerek hatásaitól befolyásolva kölcsönhatásba lép az anyai immunrendszerrel. Számos anyai tényező – beleértve a hormonokat, a citokineket és a mikrobiomot – módosíthatja az intrauterin környezetet, ezáltal befolyásolva a magzati immunrendszer fejlődését. A fokozott stresszben élő anyák csecsemőinél nagyobb az allergia és a gyomor-bél rendszeri rendellenességek aránya. A várandós étrendje is befolyásolja a magzati mikrobiomot a méh közvetítésével. A bélflóránk, vagyis a mikrobiom, a belünkben élő mikrobák összessége és szimbiózisa, amelynek kényes egyensúlya már csecsemőkorban kialakul, és döntően meghatározza az intestinalis barrier és a bélasszociált immunrendszer működését. A probiotikumok szaporodásához szükséges prebiotikummal is befolyásolható a bélflóra. A pre- és a probiotikum kombinációja a szimbiotikum. Az anyatej a patogénekkel szemben protektív hatású, részben azáltal, hogy emeli a Bifidobacterium-számot az újszülött bélflórájában. A dysbiosis a kommenzális, egészséges bélflóra megváltozása. Ennek szerepét feltételezik funkcionális gastrointestinalis kórképekben, egyre több pszichiátriai és neurológiai kórképben is, mint az autizmus-spektrumzavar. Orv Hetil. 2021; 162(19): 731–740. Summary. The human microbiome is the totality of microbe communities living in the human body and on the human body surface, most of which live in the gastrointestinal tract. These microbe communities contain many and varied bacteria, fungi, viruses, archaea and protozoa. This microbial community or microbiota in the host is largely reciprocal and takes care of nutrient metabolism in the gut, calibrates metabolism, teaches the immune system, maintains community integrity, and protects against pathogens. The fetus to be born is adequately supplied with nutrients from the maternal bloodstream, and thus microbial-induced bacterial components or metabolites can be efficiently transferred to the fetus in the maternal body. Maternal microbial communities, including prenatal intestinal, vaginal, oral, and dermal microbiomes, actually undergo pronounced changes during pregnancy that can affect health maintenance and contribute to the development of well-known diseases. The fetus is not sterile or immunologically naïve, but interacts with the maternal immune system through the effects of environmental stimuli through the mother. Many maternal factors, including hormones, cytokines, and the microbiome, can modify the intrauterine environment, thereby affecting the development of the fetal immune system. Infants of mothers under increased stress have higher rates of allergies and gastrointestinal disorders. The diet of the gravida also affects the fetal microbiome through the uterus. Our intestinal flora, or microbiome, is the totality and symbiosis of the microbes living in them, the delicate balance of which is established in infancy and decisively determines the functioning of the intestinal barrier and the intestinal associated immune system. The prebiotic required for the proliferation of probiotics can also affect the intestinal flora. The combination of pre- and probiotic is symbiotic. Breast milk has a protective effect against pathogens, in part by raising the number of Bifidobacteria in the intestinal flora of the newborn. Dysbiosis is a change in the commensal, healthy gut flora. Its role is hypothesized in functional gastrointestinal disorders, as well as in more and more psychiatric and neurological disorders such as the autism spectrum disorder. Orv Hetil. 2021; 162(19): 731–740.

scholarly journals Maternal Prenatal Microbiome and Infant’s Immune System at the Origins of the Development of Health and Disease

2021 ◽  
Author(s):  
Iván Enrique Naranjo Logroño ◽  
Leslie Gricel Cuzco Macías ◽  
Alison Tamara Ruiz Chico ◽  
Anthony Alfonso Naranjo Coronel
Keyword(s):  
Immune System ◽  
Randomized Clinical Trials ◽  
Human Microbiome ◽  
First Year ◽  
El Sistema ◽  
Health And Disease ◽  
Land Surfaces ◽  
First Year Of Life ◽  
Relationship Of ◽  
The Relationship

Introduction: The human microbiome refers to the presence of microorganisms that live with its host. Objective: To analyze the relationship between the maternal perinatal microbiome and the development of the infant’s immune system, at the origins of the development of health and disease. Methodology: A non-systematic bibliographic review was carried out, including those controlled and randomized clinical trials focused on the relationship of the prenatal maternal microbiome and the infant’s immune system. And all those works whose approach was different from the topic raised were excluded. Discussion: 20 min after birth, the microbiome of newborns by vaginal delivery resembles the microbiota of their mother’s vagina, while those born by caesarean section house microbial communities that are usually found in human skin. The acquisition of the microbiome continues during the first years of life, with a microbiome of the baby’s gastrointestinal tract beginning to resemble that of an adult from the first year of life. Conclusion: Bacteria are microorganisms that have managed to colonize the vast majority of land surfaces, showing great adaptability. The human being is not indifferent, and hypotheses have been raised that affirm his participation in the development of health and the onset of the disease. Keywords: microbiota, inmune system, infant nutritional physiological phenomena. RESUMEN Introducción: El microbioma humano se refiere a la presencia de microorganismos que conviven con su hospedero. Objetivo: Analizar la relación existente entre el microbioma materno perinatal y el desarrollo del sistema inmune del lactante, en los orígenes del desarrollo de la salud y enfermedad. Metodología: Se realizó una revisión bibliográfica no sistemática, donde se incluyeron aquellos ensayos clínicos controlados y randomizados enfocados en la relación del microbioma materno prenatal y el sistema inmune del lactante. Y se excluyeron todos aquellos trabajos cuyo enfoque fue diferente al tema planteado. Resultados: Se encontraron 61 fuentes bibliográficas, de las cuales se incluyeron 53 artículos que contenían la información relacionada al tema y publicados en los últimos 11 años. Discusión: 20 min después del nacimiento, el microbioma de los recién nacidos por parto vaginal se asemeja a la microbiota de la vagina de su madre, mientras que los nacidos por cesárea albergan comunidades microbianas que generalmente se encuentran en la piel humana. La adquisición del microbioma continúa durante los primeros años de vida, con un el microbioma del tracto gastrointestinal del bebé comienza a parecerse al de un adulto desde el primer año de vida. Conclusiones: Las bacterias, son microorganismos que han logrado colonizar la gran mayoría de las superficies terrestres, mostrando una gran capacidad de adaptación. El ser humano, no es indiferente, y se han planteado hipótesis que aseveran su participación en el desarrollo de la salud e inicio de la enfermedad. Palabras clave: microbiota, sistema inmunológico, fenómenos fisiológicos nutricionales del lactante.

Causative Microbes in Host-Microbiome Interactions

2021 ◽  
Vol 75 (1) ◽  
Author(s):  
Graham J. Britton ◽  
Jeremiah J. Faith
Keyword(s):  
Immune System ◽  
Human Microbiome ◽  
Individual Species ◽  
Annual Review ◽  
Publication Date ◽  
Sequencing Technology ◽  
Specific Effects ◽  
Therapeutic Benefits ◽  
Experimental Approaches

Despite identification of numerous associations between microbiomes and diseases, the complexity of the human microbiome has hindered identification of individual species and strains that are causative in host phenotype or disease. Uncovering causative microbes is vital to fully understand disease processes and to harness the potential therapeutic benefits of microbiota manipulation. Developments in sequencing technology, animal models, and bacterial culturing have facilitated the discovery of specific microbes that impact the host and are beginning to advance the characterization of host-microbiome interaction mechanisms. We summarize the historical and contemporary experimental approaches taken to uncover microbes from the microbiota that affect host biology and describe examples of commensals that have specific effects on the immune system, inflammation, and metabolism. There is still much to learn, and we lay out challenges faced by the field and suggest potential remedies for common pitfalls encountered in the hunt for causative commensal microbes. Expected final online publication date for the Annual Review of Microbiology, Volume 75 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Human Microbiome and Its Medical Applications

2022 ◽  
Vol 8 ◽  
Author(s):  
Yangming Zhang ◽  
Linguang Zhou ◽  
Jialin Xia ◽  
Ce Dong ◽  
Xiaozhou Luo
Keyword(s):  
Immune System ◽  
Synthetic Biology ◽  
Liver Diseases ◽  
Human Microbiome ◽  
Clinical Applications ◽  
Medical Applications ◽  
Immune System Activation ◽  
Complex Functions ◽  
System Activation ◽  
Underlying Mechanisms

The commensal microbiome is essential for human health and is involved in many processes in the human body, such as the metabolism process and immune system activation. Emerging evidence implies that specific changes in the microbiome participate in the development of various diseases, including diabetes, liver diseases, tumors, and pathogen infections. Thus, intervention on the microbiome is becoming a novel and effective method to treat such diseases. Synthetic biology empowers researchers to create strains with unique and complex functions, making the use of engineered microbes for clinical applications attainable. The aim of this review is to summarize recent advances about the roles of the microbiome in certain diseases and the underlying mechanisms, as well as the use of engineered microbes in the prevention, detection, and treatment of various diseases.

Human Microbiome and Allergic Diseases in Children: Pathogenetic Role and Therapeutic Options

2020 ◽  
Vol 16 (2) ◽  
pp. 89-94
Author(s):  
Paola Musso ◽  
Elena Chiappini ◽  
Roberto Bernardini
Keyword(s):  
Immune System ◽  
Immune Modulation ◽  
Neonatal Period ◽  
Human Microbiome ◽  
Allergic Diseases ◽  
Extensive Study ◽  
Special Focus ◽  
Rural Environments ◽  
Enormous Amount ◽  
Paediatric Age

The recent and extensive study of the microbiome has provided an enormous amount of data concerning the type and possible functions of microorganisms present in the gut, airways, genital tract, and skin. These data showed interpersonal differences in the composition of the microbiome and these differences suggest a link between the microbiome, the immune modulation, and the pathogenesis of allergic diseases. This research is particularly relevant in paediatrics, since allergic diseases are constantly increasing and there is evidence in the paediatric age that shows that the composition of the microbiome in the foetal and neonatal period plays a key role in the development of the immune system: vaginal delivery, breastfeeding, childhood spent in rural environments and/or in contact with animals result in a greater biodiversity of the microbiome with the presence of protective species that reduce the activation of Th2 lymphocytes, involved in allergic reactions. Further studies are necessary to better understand the microbiota role in the pathogenesis of atopy in order to understand if specific probiotics and prebiotics, administered orally or topically, can affect the microbiota composition and modulate immune system functions, producing a therapeutic effect in the treatment of allergic diseases. This narrative review analysed the available literature regarding the correlation between the microbiome and the development of allergic diseases and with special focus on paediatric studies. The skin, gut or lung dysbiosis can be a cofactor in the pathogenesis of allergies and the remodulation of the microbiome becomes an important therapeutic challenge.

scholarly journals The Human Microbiome and Gender Medicine

2018 ◽  
Vol 2 (4) ◽  
pp. 123-127 ◽  
Author(s):  
Gali Levy ◽  
Ido Solt
Keyword(s):  
Diabetes Mellitus ◽  
Immune System ◽  
Autoimmune Disease ◽  
Microbial Communities ◽  
Molecular Genetics ◽  
Sex Hormones ◽  
Human Microbiome ◽  
Gender Medicine ◽  
Biological Sex ◽  
And Gender

Discoveries in molecular genetics over the last two decades have broadened our information about the genomics of complex microbial communities. As in all other fields of medicine, there is an undeniable need to explore the microbiome and the way it is impacted by biological sex. A number, although small, of recent studies have demonstrated that women and men have striking differences in the species that constitute their microbiomes. This effects pathological physiology in fields such as hepatology, oncology, autoimmune disease (most notably diabetes mellitus), autism, and obstetrics. There is still an unfortunate lack of research being done on the “microgenderome”: the interaction between microbiota, sex hormones, and the immune system. This review will highlight some of the main areas to be affected by microgenderome physiology, with an in depth focus on obstetrics.

Human Microbiome and Allergic Diseases in Children: Pathogenetic Role and Therapeutic Options

2020 ◽  
Vol 16 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Paola Musso ◽  
Elena Chiappini ◽  
Roberto Bernardini
Keyword(s):  
Immune System ◽  
Immune Modulation ◽  
Neonatal Period ◽  
Human Microbiome ◽  
Allergic Diseases ◽  
Extensive Study ◽  
Special Focus ◽  
Rural Environments ◽  
Enormous Amount ◽  
Paediatric Age

: The recent and extensive study of the microbiome has provided an enormous amount of data concerning the type and possible functions of microorganisms present in the gut, airways, genital tract, and skin. These data showed interpersonal differences in the composition of the microbiome and these differences suggest a link between the microbiome, the immune modulation, and the pathogenesis of allergic diseases. : This research is particularly relevant in paediatrics, since allergic diseases are constantly increasing and there is evidence in the paediatric age that shows that the composition of the microbiome in the foetal and neonatal period plays a key role in the development of the immune system: vaginal delivery, breastfeeding, childhood spent in rural environments and/or in contact with animals result in a greater biodiversity of the microbiome with the presence of protective species that reduce the activation of Th2 lymphocytes, involved in allergic reactions. : Further studies are necessary to better understand the microbiota role in the pathogenesis of atopy in order to understand if specific probiotics and prebiotics, administered orally or topically, can affect the microbiota composition and modulate immune system functions, producing a therapeutic effect in the treatment of allergic diseases. : This narrative review analysed the available literature regarding the correlation between the microbiome and the development of allergic diseases and with special focus on paediatric studies. The skin, gut or lung dysbiosis can be a cofactor in the pathogenesis of allergies and the remodulation of the microbiome becomes an important therapeutic challenge.

scholarly journals Microbiome and Asthma: What Have Experimental Models Already Taught Us?

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
R. Bonamichi-Santos ◽  
M. V. Aun ◽  
R. C. Agondi ◽  
J. Kalil ◽  
P. Giavina-Bianchi
Keyword(s):  
Immune System ◽  
Inflammatory Disease ◽  
Scientific Community ◽  
Inflammatory Diseases ◽  
Human Microbiome ◽  
Chronic Inflammatory Disease ◽  
Experimental Models ◽  
Murine Models ◽  
Respiratory Inflammation ◽  
The Relationship

Asthma is a chronic inflammatory disease that imposes a substantial burden on patients, their families, and the community. Although many aspects of the pathogenesis of classical allergic asthma are well known by the scientific community, other points are not yet understood. Experimental asthma models, particularly murine models, have been used for over 100 years in order to better understand the immunopathology of asthma. It has been shown that human microbiome is an important component in the development of the immune system. Furthermore, the occurrence of many inflammatory diseases is influenced by the presence of microbes. Again, experimental models of asthma have helped researchers to understand the relationship between the microbiome and respiratory inflammation. In this review, we discuss the evolution of murine models of asthma and approach the major studies involving the microbiome and asthma.

scholarly journals Cooperation and cheating as innovation: insights from cellular societies

2017 ◽  
Vol 372 (1735) ◽  
pp. 20160421 ◽  
Author(s):  
Athena Aktipis ◽  
Carlo C. Maley
Keyword(s):  
Immune System ◽  
Microbial Communities ◽  
Social Systems ◽  
Human Microbiome ◽  
Adaptive Immune System ◽  
The Body ◽  
Adaptive Immune ◽  
Constant Tension ◽  
Cellular Cooperation ◽  
Multicellular Organisms

The capacity to innovate is often considered a defining feature of human societies, but it is not a capacity that is unique to human societies: innovation occurs in cellular societies as well. Cellular societies such as multicellular bodies and microbial communities, including the human microbiome, are capable of innovation in response to novel opportunities and threats. Multicellularity represents a suite of innovations for cellular cooperation, but multicellularity also opened up novel opportunities for cells to cheat, exploiting the infrastructure and resources of the body. Multicellular bodies evolve less quickly than the cells within them, leaving them vulnerable to cellular innovations that can lead to cancer and infections. In order to counter these threats, multicellular bodies deploy additional innovations including the adaptive immune system and the development of partnerships with preferred microbial partners. What can we learn from examining these innovations in cooperation and cheating in cellular societies? First, innovation in social systems involves a constant tension between novel mechanisms that enable greater size and complexity of cooperative entities and novel ways of cheating. Second, cultivating cooperation with partners who can rapidly and effectively innovate (such as microbes) is important for large entities including multicellular bodies. And third, multicellularity enabled cells to manage risk socially, allowing organisms to survive in challenging environments where life would otherwise be impossible. Throughout, we ask how insights from cellular societies might be translated into new innovations in human health and medicine, promoting and protecting the cellular cooperation that makes us viable multicellular organisms. This article is part of the themed issue ‘Process and pattern in innovations from cells to societies’.

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