scholarly journals Altered error-related brain activity in youth with major depression

2012 ◽  
Vol 2 (3) ◽  
pp. 351-362 ◽  
Author(s):  
Cecile D. Ladouceur ◽  
John S. Slifka ◽  
Ronald E. Dahl ◽  
Boris Birmaher ◽  
David A. Axelson ◽  
...  
Keyword(s):  
Major Depression ◽  
Brain Activity

Altered patterns of brain activity during transient sadness in children at familial risk for major depression

2011 ◽  
Vol 135 (1-3) ◽  
pp. 410-413 ◽  
Author(s):  
Mélissa L. Lévesque ◽  
Mario Beauregard ◽  
Koen W. Ottenhof ◽  
Émilie Fortier ◽  
Richard E. Tremblay ◽  
...  
Keyword(s):  
Major Depression ◽  
Brain Activity ◽  
Familial Risk

Neural correlates of ‘pessimistic’ attitude in depression

2009 ◽  
Vol 40 (5) ◽  
pp. 789-800 ◽  
Author(s):  
U. Herwig ◽  
A. B. Brühl ◽  
T. Kaffenberger ◽  
T. Baumgartner ◽  
H. Boeker ◽  
...  
Keyword(s):  
Major Depression ◽  
Internal State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Brain Activation ◽  
Control Group ◽  
Depressed Patients ◽  
The Future ◽  
Dorsolateral Prefrontal ◽  
Pessimistic Attitude

BackgroundPreparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that ‘pessimism’-related emotion processing would characterize brain activity in major depression.MethodDuring functional magnetic resonance imaging, depressed patients and a healthy control group were cued to expect and then perceive pictures of known emotional valences – pleasant, unpleasant and neutral – and stimuli of unknown valence that could have been either pleasant or unpleasant. Brain activation associated with the ‘unknown’ expectation was compared with the ‘known’ expectation conditions.ResultsWhile anticipating pictures of unknown valence, activation patterns in depressed patients within the medial and dorsolateral prefrontal areas, inferior frontal gyrus, insula and medial thalamus were similar to activations associated with expecting unpleasant pictures, but not with expecting positive pictures. The activity within a majority of these areas correlated with the depression scores. Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations.ConclusionsBrain activation in depression during expecting events of unknown emotional valence was comparable with activation while expecting certainly negative, but not positive events. This neurobiological finding is consistent with cognitive models supposing that depressed patients develop a ‘pessimistic’ attitude towards events with an unknown emotional meaning. Thereby, particularly the role of brain areas associated with the processing of cognitive and executive control and of the internal state is emphasized in contributing to major depression.

scholarly journals Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jiaying Gong ◽  
Junjing Wang ◽  
Shaojuan Qiu ◽  
Pan Chen ◽  
Zhenye Luo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depression ◽  
Brain Activity ◽  
Meta Analysis ◽  
Inferior Frontal Gyrus ◽  
Superior Temporal Gyrus ◽  
Occipital Cortex ◽  
Anterior Cingulate ◽  
The Right ◽  
Intrinsic Brain Activity

Abstract Identification of intrinsic brain activity differences and similarities between major depression (MDD) and bipolar disorder (BD) is necessary. However, results have not yet yielded consistent conclusions. A meta-analysis of whole-brain resting-state functional MRI (rs-fMRI) studies that explored differences in the amplitude of low-frequency fluctuation (ALFF) between patients (including MDD and BD) and healthy controls (HCs) was conducted using seed-based d mapping software. Systematic literature search identified 50 studies comparing 1399 MDD patients and 1332 HCs, and 15 studies comparing 494 BD patients and 593 HCs. MDD patients displayed increased ALFF in the right superior frontal gyrus (SFG) (including the medial orbitofrontal cortex, medial prefrontal cortex [mPFC], anterior cingulate cortex [ACC]), bilateral insula extending into the striatum and left supramarginal gyrus and decreased ALFF in the bilateral cerebellum, bilateral precuneus, and left occipital cortex compared with HCs. BD showed increased ALFF in the bilateral inferior frontal gyrus, bilateral insula extending into the striatum, right SFG, and right superior temporal gyrus (STG) and decreased ALFF in the bilateral precuneus, left cerebellum (extending to the occipital cortex), left ACC, and left STG. In addition, MDD displayed increased ALFF in the left lingual gyrus, left ACC, bilateral precuneus/posterior cingulate gyrus, and left STG and decreased ALFF in the right insula, right mPFC, right fusiform gyrus, and bilateral striatum relative to BD patients. Conjunction analysis showed increased ALFF in the bilateral insula, mPFC, and decreased ALFF in the left cerebellum in both disorders. Our comprehensive meta-analysis suggests that MDD and BD show a common pattern of aberrant regional intrinsic brain activity which predominantly includes the insula, mPFC, and cerebellum, while the limbic system and occipital cortex may be associated with spatially distinct patterns of brain function, which provide useful insights for understanding the underlying pathophysiology of brain dysfunction in affective disorders, and developing more targeted and efficacious treatment and intervention strategies.

Reduced Sustained Brain Activity During Processing of Positive Emotional Stimuli in Major Depression

2005 ◽  
Vol 57 (10) ◽  
pp. 1089-1096 ◽  
Author(s):  
Avgusta Y. Shestyuk ◽  
Patricia J. Deldin ◽  
Jordan E. Brand ◽  
Christen M. Deveney
Keyword(s):  
Major Depression ◽  
Brain Activity ◽  
Emotional Stimuli

Brain activity in patients with deficiency versus excess patterns of major depression: A task fMRI study

2019 ◽  
Vol 42 ◽  
pp. 292-297 ◽  
Author(s):  
Yong-zhi Wang ◽  
Yu Han ◽  
Jing-jie Zhao ◽  
Yi Du ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Major Depression ◽  
Brain Activity ◽  
Fmri Study
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