Characterization of a scavenger receptor cysteine-rich-domain-containing protein of the starfish, Asterina pectinifera: ApSRCR1 acts as an opsonin in the larval and adult innate immune systems

2012 ◽  
Vol 36 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Ryohei Furukawa ◽  
Midori Matsumoto ◽  
Hiroyuki Kaneko
Keyword(s):  
Scavenger Receptor ◽  
Innate Immune ◽  
Immune Systems ◽  
Rich Domain ◽  
Asterina Pectinifera ◽  
Cysteine Rich Domain

scholarly journals Structural characterization of the third scavenger receptor cysteine‐rich domain of murine neurotrypsin

2019 ◽  
Vol 28 (4) ◽  
pp. 746-755 ◽  
Author(s):  
Anselmo Canciani ◽  
Gianluca Catucci ◽  
Federico Forneris
Keyword(s):  
Structural Characterization ◽  
Scavenger Receptor ◽  
The Third ◽  
Rich Domain ◽  
Cysteine Rich Domain

scholarly journals The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors

2015 ◽  
Vol 6 ◽  
Author(s):  
Nicholas V. L. Yap ◽  
Fiona J. Whelan ◽  
Dawn M. E. Bowdish ◽  
G. Brian Golding
Keyword(s):  
Scavenger Receptor ◽  
Scavenger Receptors ◽  
Class A ◽  
Rich Domain ◽  
Cysteine Rich Domain

The Ly-1. 1 and Ly-1. 2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain

1997 ◽  
Vol 49 (1) ◽  
pp. 1-6 ◽  
Author(s):  
G. C. Starling ◽  
M. -B. C. Llewellyn ◽  
G. S. Whitney ◽  
A. Aruffo
Keyword(s):  
Scavenger Receptor ◽  
Rich Domain ◽  
Cysteine Rich Domain

scholarly journals The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site

1995 ◽  
Vol 270 (31) ◽  
pp. 18187-18190 ◽  
Author(s):  
Gena S. Whitney ◽  
Gary C. Starling ◽  
Michael A. Bowen ◽  
Brett Modrell ◽  
Anthony W. Siadak ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Binding Site ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Scavenger Receptor ◽  
Rich Domain ◽  
Cysteine Rich Domain

scholarly journals Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗

2012 ◽  
Vol 103 (11) ◽  
pp. 2331-2340 ◽  
Author(s):  
Sivananthaperumal Shanmugasundararaj ◽  
Joydip Das ◽  
Warren S. Sandberg ◽  
Xiaojuan Zhou ◽  
Dan Wang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Binding Site ◽  
Functional Characterization ◽  
Rich Domain ◽  
Cysteine Rich Domain ◽  
Protein Kinase Cδ

scholarly journals Increased Susceptibility of  Thymocytes to Apoptosis in Mice Lacking AIM, a Novel Murine Macrophage-derived Soluble Factor Belonging to the Scavenger Receptor Cysteine-rich Domain Superfamily

1999 ◽  
Vol 189 (2) ◽  
pp. 413-422 ◽  
Author(s):  
Toru Miyazaki ◽  
Yumiko Hirokami ◽  
Nobuyuki Matsuhashi ◽  
Hisakazu Takatsuka ◽  
Makoto Naito
Keyword(s):  
Scavenger Receptor ◽  
The Body ◽  
Murine Macrophage ◽  
Double Positive ◽  
Differential Signal ◽  
Rich Domain ◽  
Macrophage Scavenger Receptor ◽  
Cysteine Rich Domain

Apoptosis of cells must be regulated both positively and negatively in response to a variety of stimuli in the body. Various environmental stresses are known to initiate apoptosis via differential signal transduction cascades. However, induction of signals that may inhibit apoptosis is poorly understood, although a number of intracellular molecules that mediate inhibition of apoptosis have been identified. Here we present a novel murine macrophage-specific 54-kD secreted protein which inhibits apoptosis (termed AIM, for apoptosis inhibitor expressed by macrophages). AIM belongs to the macrophage scavenger receptor cysteine-rich domain superfamily (SRCR-SF), members of which share a highly homologous conserved cysteine-rich domain. In AIM-deficient mice, the thymocyte numbers were diminished to half those in wild-type mice, and CD4/CD8 double-positive (DP) thymocytes were strikingly more susceptible to apoptosis induced by both dexamethasone and irradiation in vivo. Recombinant AIM protein significantly inhibited cell death of DP thymocytes in response to a variety of stimuli in vitro. These results indicate that in the thymus, AIM functions in trans to induce resistance to apoptosis within DP cells, and thus supports the viability of DP thymocytes before thymic selection.

scholarly journals Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization

2013 ◽  
Vol 20 (1) ◽  
pp. 54 ◽  
Author(s):  
Fong-Lee Huang ◽  
Young-Ji Shiao ◽  
Sheue-Jane Hou ◽  
Cheng-Ning Yang ◽  
Yi-Jen Chen ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Rich Domain ◽  
Cysteine Rich Domain
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