scholarly journals Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗

2012 ◽  
Vol 103 (11) ◽  
pp. 2331-2340 ◽  
Author(s):  
Sivananthaperumal Shanmugasundararaj ◽  
Joydip Das ◽  
Warren S. Sandberg ◽  
Xiaojuan Zhou ◽  
Dan Wang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Binding Site ◽  
Functional Characterization ◽  
Rich Domain ◽  
Cysteine Rich Domain ◽  
Protein Kinase Cδ

scholarly journals Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase C δ

2006 ◽  
Vol 15 (9) ◽  
pp. 2107-2119 ◽  
Author(s):  
Joydip Das ◽  
Xiaojuan Zhou ◽  
Keith W. Miller
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Binding Site ◽  
Rich Domain ◽  
Kinase C ◽  
Cysteine Rich Domain

scholarly journals Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells.

1992 ◽  
Vol 267 (14) ◽  
pp. 10011-10017
Author(s):  
J Grabarek ◽  
M Raychowdhury ◽  
K Ravid ◽  
K.C. Kent ◽  
P.J. Newman ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Functional Characterization ◽  
Kinase C ◽  
Hel Cells

scholarly journals Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl

FEBS Journal ◽  
2006 ◽  
Vol 273 (23) ◽  
pp. 5442-5456 ◽  
Author(s):  
Archana Sanjay ◽  
Tsuyoshi Miyazaki ◽  
Cecile Itzstein ◽  
Enkhtsetseg Purev ◽  
William C. Horne ◽  
...  
Keyword(s):  
Binding Site ◽  
Functional Characterization ◽  
Src Homology ◽  
Domain 3

scholarly journals Structural and Functional Characterization of Monomeric EphrinA1 Binding Site to EphA2 Receptor

2012 ◽  
Vol 287 (17) ◽  
pp. 14012-14022 ◽  
Author(s):  
Carla M. Lema Tomé ◽  
Enzo Palma ◽  
Sara Ferluga ◽  
W. Todd Lowther ◽  
Roy Hantgan ◽  
...  
Keyword(s):  
Binding Site ◽  
Functional Characterization

scholarly journals Structural characterization of the third scavenger receptor cysteine‐rich domain of murine neurotrypsin

2019 ◽  
Vol 28 (4) ◽  
pp. 746-755 ◽  
Author(s):  
Anselmo Canciani ◽  
Gianluca Catucci ◽  
Federico Forneris
Keyword(s):  
Structural Characterization ◽  
Scavenger Receptor ◽  
The Third ◽  
Rich Domain ◽  
Cysteine Rich Domain

scholarly journals Multiple interactions between pituitary hormones and the mannose receptor

1999 ◽  
Vol 343 (2) ◽  
pp. 403-411 ◽  
Author(s):  
Daniel Z. SIMPSON ◽  
Paul G. HITCHEN ◽  
Elizabeth L. ELMHIRST ◽  
Maureen E. TAYLOR
Keyword(s):  
Ionic Strength ◽  
Binding Site ◽  
Specific Binding ◽  
Mannose Receptor ◽  
Pituitary Hormones ◽  
Pituitary Hormone ◽  
Truncated Form ◽  
Additional Function ◽  
Rich Domain ◽  
Cysteine Rich Domain

The macrophage mannose receptor, which has a well-documented role in the innate immune system, has an additional function in the clearance of pituitary hormones. Clearance is mediated by the recognition of sulphated terminal N-acetylgalactosamine residues (SO4-4GalNAc) on the hormones. Previous studies with an SO4-4GalNAc-containing neoglycoprotein suggest that the SO4-4GalNAc-binding site is localized to the N-terminal cysteine-rich domain of the receptor, distinct from the mannose/N-acetylglucosamine/fucose-specific C-type carbohydrate-recognition domains (CRDs). The present study characterizes the binding of natural pituitary hormone ligands to a soluble portion of the mannose receptor consisting of the whole extracellular domain and to a truncated form containing the eight CRDs but lacking the N-terminal cysteine-rich domain and the fibronectin type II repeat. Both forms of the receptor show high-affinity saturable binding of lutropin and thyrotropin. Binding to the full-length receptor is dependent on pH and ionic strength and is inhibited effectively by SO4-4GalNAc but only partly by mannose. In contrast, binding to the truncated form of the receptor, which is also dependent on pH and ionic strength, is inhibited by mannose but not by SO4-4GalNAc. The results are consistent with the presence of an SO4-4GalNAc-specific binding site in the cysteine-rich domain of the mannose receptor but indicate that interactions between other sugars on the hormones and the CRDs are also important in hormone binding.

scholarly journals The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site

1995 ◽  
Vol 270 (31) ◽  
pp. 18187-18190 ◽  
Author(s):  
Gena S. Whitney ◽  
Gary C. Starling ◽  
Michael A. Bowen ◽  
Brett Modrell ◽  
Anthony W. Siadak ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Binding Site ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Scavenger Receptor ◽  
Rich Domain ◽  
Cysteine Rich Domain
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