Distinct cognitive components and their neural substrates underlying praxis and language deficits following left hemisphere stroke

Cortex ◽  
2021 ◽  
Author(s):  
Claudia C. Schmidt ◽  
Elisabeth I.S. Achilles ◽  
Gereon R. Fink ◽  
Peter H. Weiss
Keyword(s):  
Left Hemisphere ◽  
Neural Substrates ◽  
Language Deficits ◽  
Cognitive Components ◽  
Left Hemisphere Stroke

scholarly journals Shared and Distinct Neuroanatomic Regions Critical for Tool-related Action Production and Recognition: Evidence from 131 Left-hemisphere Stroke Patients

2015 ◽  
Vol 27 (12) ◽  
pp. 2491-2511 ◽  
Author(s):  
Leyla Y. Tarhan ◽  
Christine E. Watson ◽  
Laurel J. Buxbaum
Keyword(s):  
Left Hemisphere ◽  
Mirror Neuron System ◽  
Inferior Frontal Gyrus ◽  
Occipital Cortex ◽  
Neural Substrates ◽  
Middle Temporal Gyrus ◽  
Stroke Patients ◽  
Middle Temporal ◽  
Impaired Performance ◽  
Left Hemisphere Stroke

The inferior frontal gyrus and inferior parietal lobe have been characterized as human homologues of the monkey “mirror neuron” system, critical for both action production (AP) and action recognition (AR). However, data from brain lesion patients with selective impairment on only one of these tasks provide evidence of neural and cognitive dissociations. We sought to clarify the relationship between AP and AR, and their critical neural substrates, by directly comparing performance of 131 chronic left-hemisphere stroke patients on both tasks—to our knowledge, the largest lesion-based experimental investigation of action cognition to date. Using voxel-based lesion-symptom mapping, we found that lesions to primary motor and somatosensory cortices and inferior parietal lobule were associated with disproportionately impaired performance on AP, whereas lesions to lateral temporo-occipital cortex were associated with a relatively rare pattern of disproportionately impaired performance on AR. In contrast, damage to posterior middle temporal gyrus was associated with impairment on both AP and AR. The distinction between lateral temporo-occipital cortex, critical for recognition, and posterior middle temporal gyrus, important for both tasks, suggests a rough gradient from modality-specific to abstract representations in posterior temporal cortex, the first lesion-based evidence for this phenomenon. Overall, the results of this large patient study help to bring closure to a long-standing debate by showing that tool-related AP and AR critically depend on both common and distinct left hemisphere neural substrates, most of which are external to putative human mirror regions.

scholarly journals Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study

2016 ◽  
Vol 116 (3) ◽  
pp. 1387-1395 ◽  
Author(s):  
Raghavan Gopalakrishnan ◽  
Richard C. Burgess ◽  
Scott F. Lempka ◽  
John T. Gale ◽  
Darlene P. Floden ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Visual Cues ◽  
Neural Substrates ◽  
Cognitive Networks ◽  
Therapeutic Approaches ◽  
Pain Experience ◽  
Time Frequency ◽  
Cognitive Components ◽  
Chronic Effects ◽  
Integrated Approaches

Central poststroke pain (CPSP) is characterized by hemianesthesia associated with unrelenting chronic pain. The final pain experience stems from interactions between sensory, affective, and cognitive components of chronic pain. Hence, managing CPSP will require integrated approaches aimed not only at the sensory but also the affective-cognitive spheres. A better understanding of the brain's processing of pain anticipation is critical for the development of novel therapeutic approaches that target affective-cognitive networks and alleviate pain-related disability. We used magnetoencephalography (MEG) to characterize the neural substrates of pain anticipation in patients suffering from intractable CPSP. Simple visual cues evoked anticipation while patients awaited impending painful (PS), nonpainful (NPS), or no stimulus (NOS) to their nonaffected and affected extremities. MEG responses were studied at gradiometer level using event-related fields analysis and time-frequency oscillatory analysis upon source localization. On the nonaffected side, significantly greater responses were recorded during PS. PS (vs. NPS and NOS) exhibited significant parietal and frontal cortical activations in the beta and gamma bands, respectively, whereas NPS (vs. NOS) displayed greater activation in the orbitofrontal cortex. On the affected extremity, PS (vs. NPS) did not show significantly greater responses. These data suggest that anticipatory phenomena can modulate neural activity when painful stimuli are applied to the nonaffected extremity but not the affected extremity in CPSP patients. This dichotomy may stem from the chronic effects of pain on neural networks leading to habituation or saturation. Future clinically effective therapies will likely be associated with partial normalization of the neurophysiological correlates of pain anticipation.

Praxis Lateralization: Errors in Right and Left Hemisphere Stroke

Cortex ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 219-230 ◽  
Author(s):  
Brenda Hanna-Pladdy ◽  
Stephanie K. Daniels ◽  
Melanie A. Fieselman ◽  
Kenneth Thompson ◽  
Jennifer J. Vasterling ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Left Hemisphere Stroke

scholarly journals Phonotactic processing deficit following left-hemisphere stroke

Cortex ◽  
2018 ◽  
Vol 99 ◽  
pp. 346-357 ◽  
Author(s):  
Maryam Ghaleh ◽  
Laura M. Skipper-Kallal ◽  
Shihui Xing ◽  
Elizabeth Lacey ◽  
Iain DeWitt ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Processing Deficit ◽  
Left Hemisphere Stroke

scholarly journals Strong conceptual ability reduces the effect of lexical impairments on verb retrieval in aphasia

2021 ◽  
Author(s):  
Haley C. Dresang ◽  
William D. Hula ◽  
Tessa Warren ◽  
Michael Walsh Dickey
Keyword(s):  
Left Hemisphere ◽  
Language Processing ◽  
Brain Injuries ◽  
Conceptual Processing ◽  
Action Processing ◽  
Processing Abilities ◽  
Conceptual Ability ◽  
Chronic Aphasia ◽  
Left Hemisphere Stroke ◽  
Open Question

Verb-retrieval impairments are pervasive deficits that can negatively impact communicative function for individuals living with aphasia. Unfortunately, the neurocognitive basis of these deficits remains poorly understood. One open question is the degree to which verb-retrieval impairments might be rooted in lexical- versus conceptual-processing deficits. These deficits can be co-present and correlated in people with aphasia, but they have also been found to be dissociated in patients with a variety of acquired brain injuries. This study examined the degree to which conceptual versus lexical action-processing abilities are impaired and may contribute to verb-retrieval impairments in adults with chronic aphasia due to left-hemisphere stroke. The results indicate that conceptual action processing can be impaired in aphasia and may contribute to verb-retrieval impairments. Furthermore, relatively unimpaired conceptual processing can ameliorate the influence of lexical impairments on verb-retrieval impairments. These findings are consistent with models in which conceptual representations play a key role in language processing and may be leveraged to improve verb retrieval in adults with chronic aphasia.

scholarly journals Regional Shape Abnormalities in Thalamus and Verbal Memory Impairment After Subcortical Infarction

2019 ◽  
Vol 33 (6) ◽  
pp. 476-485 ◽  
Author(s):  
Gang Liu ◽  
Xiaoqing Tan ◽  
Chao Dang ◽  
Shuangquan Tan ◽  
Shihui Xing ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Verbal Memory ◽  
Memory Impairment ◽  
Right Hemisphere ◽  
Brain Structures ◽  
Change Rate ◽  
Immediate Recall ◽  
Stroke Group ◽  
Left Hemisphere Stroke ◽  
Subcortical Infarction

Background. Subcortical infarcts can result in verbal memory impairment, but the potential underlying mechanisms remain unknown. Objective. We investigated the spatiotemporal deterioration patterns of brain structures in patients with subcortical infarction and identified the regions that contributed to verbal memory impairment. Methods. Cognitive assessment and structural magnetic resonance imaging were performed 1, 4, and 12 weeks after stroke onset in 28 left-hemisphere and 22 right-hemisphere stroke patients with subcortical infarction. Whole-brain volumetric analysis combined with a further-refined shape analysis was conducted to analyze longitudinal morphometric changes in brain structures and their relationship to verbal memory performance. Results. Between weeks 1 and 12, significant volume decreases in the ipsilesional basal ganglia, inferior white matter, and thalamus were found in the left-hemisphere stroke group. Among those 3 structures, only the change rate of the thalamus volume was significantly correlated with that in immediate recall. For the right-hemisphere stroke group, only the ipsilesional basal ganglia survived the week 1 to week 12 group comparison, but its change rate was not significantly correlated with the verbal memory change rate. Shape analysis of the thalamus revealed atrophies of the ipsilesional thalamic subregions connected to the prefrontal, temporal, and premotor cortices in the left-hemisphere stroke group and positive correlations between the rates of those atrophies and the change rate in immediate recall. Conclusions. Secondary damage to the thalamus, especially to the left subregions connected to specific cortices, may be associated with early verbal memory impairment following an acute subcortical infarct.

scholarly journals Reduced competition between tool action neighbors in left hemisphere stroke

Cortex ◽  
2019 ◽  
Vol 120 ◽  
pp. 269-283 ◽  
Author(s):  
Frank E. Garcea ◽  
Harrison Stoll ◽  
Laurel J. Buxbaum
Keyword(s):  
Left Hemisphere ◽  
Left Hemisphere Stroke
Sign in / Sign up

Export Citation Format

Share Document