scholarly journals Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study

2016 ◽  
Vol 116 (3) ◽  
pp. 1387-1395 ◽  
Author(s):  
Raghavan Gopalakrishnan ◽  
Richard C. Burgess ◽  
Scott F. Lempka ◽  
John T. Gale ◽  
Darlene P. Floden ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Visual Cues ◽  
Neural Substrates ◽  
Cognitive Networks ◽  
Therapeutic Approaches ◽  
Pain Experience ◽  
Time Frequency ◽  
Cognitive Components ◽  
Chronic Effects ◽  
Integrated Approaches

Central poststroke pain (CPSP) is characterized by hemianesthesia associated with unrelenting chronic pain. The final pain experience stems from interactions between sensory, affective, and cognitive components of chronic pain. Hence, managing CPSP will require integrated approaches aimed not only at the sensory but also the affective-cognitive spheres. A better understanding of the brain's processing of pain anticipation is critical for the development of novel therapeutic approaches that target affective-cognitive networks and alleviate pain-related disability. We used magnetoencephalography (MEG) to characterize the neural substrates of pain anticipation in patients suffering from intractable CPSP. Simple visual cues evoked anticipation while patients awaited impending painful (PS), nonpainful (NPS), or no stimulus (NOS) to their nonaffected and affected extremities. MEG responses were studied at gradiometer level using event-related fields analysis and time-frequency oscillatory analysis upon source localization. On the nonaffected side, significantly greater responses were recorded during PS. PS (vs. NPS and NOS) exhibited significant parietal and frontal cortical activations in the beta and gamma bands, respectively, whereas NPS (vs. NOS) displayed greater activation in the orbitofrontal cortex. On the affected extremity, PS (vs. NPS) did not show significantly greater responses. These data suggest that anticipatory phenomena can modulate neural activity when painful stimuli are applied to the nonaffected extremity but not the affected extremity in CPSP patients. This dichotomy may stem from the chronic effects of pain on neural networks leading to habituation or saturation. Future clinically effective therapies will likely be associated with partial normalization of the neurophysiological correlates of pain anticipation.

Lessons From the Neural Bases of Speech and Voice

2011 ◽  
Vol 21 (1) ◽  
pp. 5-14
Author(s):  
Christy L. Ludlow
Keyword(s):  
Brain Networks ◽  
Neural Substrates ◽  
Voice Behavior ◽  
Therapeutic Approaches ◽  
Neural Bases ◽  
Sound Foundation ◽  
The Brain ◽  
Normal Speech

The premise of this article is that increased understanding of the brain bases for normal speech and voice behavior will provide a sound foundation for developing therapeutic approaches to establish or re-establish these functions. The neural substrates involved in speech/voice behaviors, the types of muscle patterning for speech and voice, the brain networks involved and their regulation, and how they can be externally modulated for improving function will be addressed.

scholarly journals Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akhil Sharma ◽  
Arman Harutyunyan ◽  
Bernard L. Schneider ◽  
Anna Moszczynska
Keyword(s):  
Neural Substrates ◽  
Genetically Engineered ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Self Administration ◽  
Methamphetamine Use ◽  
New Therapeutic Approaches ◽  
Extended Access ◽  
High Doses ◽  
Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

Cultural Considerations in the Management of Chronic Pain

CAND Journal ◽  
2021 ◽  
Vol 28 (4) ◽  
pp. 11-13
Author(s):  
Shakila Mohmand ◽  
Sumar Chams
Keyword(s):  
Health Care ◽  
Chronic Pain ◽  
Cultural Competency ◽  
Patient Outcomes ◽  
Health Care Providers ◽  
Cultural Beliefs ◽  
Coping Mechanisms ◽  
Care Providers ◽  
Pain Experience ◽  
Cultural Considerations

Cultural competency within health care helps eliminate racial and ethnic health disparities. When assessing and treating patients with chronic pain, practitioners should feel confident in using information regarding a patient’s individual cultural beliefs due to their significant impact on the pain experience. Culture impacts perception, outlook, and communication of pain, as well as coping mechanisms. These are aspects of subjective history that influence important decisions regarding the management of chronic pain. Becoming more aware of what to look for and which questions to ask can allow naturopathic doctors and other health-care providers to continue improving therapeutic relationships and patient outcomes.

The God Prescription

2016 ◽  
Author(s):  
Lynn R. Webster
Keyword(s):  
Chronic Pain ◽  
Support System ◽  
Scientific Research ◽  
Nerve Damage ◽  
Faith Community ◽  
Pain Experience ◽  
God's Will ◽  
Severe Chronic Pain

“The God Prescription” profiles Walt Alexander, a devout Christian who developed severe chronic pain after suffering accidental nerve damage during surgery. Walt’s faith in God and his support system within his family and his faith community helped him endure his pain and look for the good that could come out of it. Conversely, his pain experience also deepened his submission to God’s will and enhanced his compassion for other people who are in need. Walt’s experience illustrates a truth that scientific research has established: belief tends to affect a person’s pain experience in a positive way. Chapter key idea: Believing in something or Someone bigger than yourself invites healing into your life.

The impact of chronic pain in children and adolescents: Development and initial validation of a child and parent version of the Pain Experience Questionnaire

Pain ◽  
2008 ◽  
Vol 135 (3) ◽  
pp. 251-261 ◽  
Author(s):  
Christiane Hermann ◽  
Johanna Hohmeister ◽  
Katrin Zohsel ◽  
Marie-Luise Tuttas ◽  
Herta Flor
Keyword(s):  
Chronic Pain ◽  
Children And Adolescents ◽  
Pain Experience ◽  
Initial Validation ◽  
The Impact ◽  
Experience Questionnaire ◽  
Parent Version

scholarly journals Neuroimaging Revolutionizes Therapeutic Approaches to Chronic Pain

2007 ◽  
Vol 3 ◽  
pp. 1744-8069-3-25 ◽  
Author(s):  
David Borsook ◽  
Eric A Moulton ◽  
Karl F Schmidt ◽  
Lino R Becerra
Keyword(s):  
Chronic Pain ◽  
Therapeutic Approaches

scholarly journals Lack of Evidence for Age Differences in Pain Beliefs

1997 ◽  
Vol 2 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Lucy Gagliese ◽  
Ronald Melzack
Keyword(s):  
Chronic Pain ◽  
Age Differences ◽  
Self Efficacy ◽  
The Elderly ◽  
Pain Experience ◽  
Pain Beliefs ◽  
Self Assessments ◽  
Normal Ageing ◽  
The Relationship

OBJECTIVE: To assess, in two studies, whether there are any age differences in beliefs about the role of psychological, organic and ageing factors in the experience of chronic pain.SUBJECTS: Healthy adults free from chronic pain ranging in age from 18 to 86 years (first study); adults with chronic pain due to arthritis, fibromyalgia or other rheumatological disorders ranging in age from 27 to 79 years (second study).MATERIALS: In both studies, subjects completed the Pain Beliefs Questionnaire which was modified to measure beliefs about the relationship between pain and ageing. In addition, subjects completed various self-assessments of health, pain intensity and depression. Those with chronic pain also completed the Arthritis Self-Efficacy Scale.RESULTS: There was no evidence of any age differences in beliefs about pain in either the pain-free or chronic pain samples. There was some evidence that elderly patients may report less pain, but there were no age differences found on measures of depression or self-efficacy.CONCLUSIONS: The elderly were no more likely than younger persons to associate pain with the normal ageing process than with organic factors such as tissue damage, nor were they more likely to deny the importance of psychological factors to the pain experience.

scholarly journals The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain

2020 ◽  
Vol 89 ◽  
pp. 1-11 ◽  
Author(s):  
Magali Millecamps ◽  
Xiang Qun Shi ◽  
Marjo Piltonen ◽  
Stefania Echeverry ◽  
Luda Diatchenko ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Experience ◽  
Geriatric Pain

scholarly journals Chronic Pain and Sleep Disorders in Primary Care

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Robert Jank ◽  
Alexander Gallee ◽  
Markus Boeckle ◽  
Sabine Fiegl ◽  
Christoph Pieh
Keyword(s):  
Primary Care ◽  
Chronic Pain ◽  
Sleep Disorders ◽  
Medical Information ◽  
Severity Index ◽  
Total Sample ◽  
Self Report ◽  
Pain Experience ◽  
Assessment And Treatment ◽  
Insomnia Severity

Background. Chronic pain (CP) and sleep disorders (SD) are highly prevalent in the general population. However, comprehensive data regarding the prevalence and characteristics of pain and SD in primary care are rare. Methods. From N=578 patients N=570 were included within 8 weeks (mean age: 50.8±18.7 years, females: 289). Sociodemographic data, Insomnia Severity Index (ISI), and parts of a self-report questionnaire for pain (Multidimensional German Pain Questionnaire) were recorded and additional medical information (pain medication, sleep medication) was gathered from the patient charts. Results. Of the total sample, 33.2% (n=189) suffer from CP (pain ≥ 6 months) and 29.1% (n=166) from SD. 45.5% of the CP patients suffer from SD and 26.5% from clinical insomnia (ISI ≥ 15). SD (β = 0.872, SE = 0.191,  t = 4,572, p<0.001, CI [0.497; 1.246]) and older age (β = 0.025, SE = 0.005, t = 5.135, p<0.001, CI [0.015; 0.035]) were significantly associated with pain experience. Conclusion. About a quarter of CP patients suffer from clinical insomnia. The suggested bidirectional relation should be considered during comprehensive assessment and treatment of patients.

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