Brain network connectivity associated with anticipatory postural control in children and adults

Cortex ◽  
2018 ◽  
Vol 108 ◽  
pp. 210-221 ◽  
Author(s):  
Fabien Cignetti ◽  
Marianne Vaugoyeau ◽  
Leslie M. Decker ◽  
Marie-Hélène Grosbras ◽  
Nadine Girard ◽  
...  
Keyword(s):  
Postural Control ◽  
Network Connectivity ◽  
Brain Network ◽  
Anticipatory Postural Control ◽  
Brain Network Connectivity

scholarly journals Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity

2021 ◽  
pp. 101000
Author(s):  
Moriah E. Thomason ◽  
Ava C. Palopoli ◽  
Nicki N. Jariwala ◽  
Denise M. Werchan ◽  
Alan Chen ◽  
...  
Keyword(s):  
Network Connectivity ◽  
Brain Network ◽  
Brain Network Connectivity ◽  
The Brain

scholarly journals Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Peng Li ◽  
Teng-Teng Fan ◽  
Rong-Jiang Zhao ◽  
Ying Han ◽  
Le Shi ◽  
...  
Keyword(s):  
Network Connectivity ◽  
Brain Network ◽  
Brain Network Connectivity

scholarly journals Childhood Trauma Associated With Abnormal Resting-State Brain Network Connectivity in First-Episode Schizophrenia Patients

2020 ◽  
Author(s):  
Xiangyun Long ◽  
Jiaxin Wu ◽  
Fei Liu ◽  
Ansi Qi ◽  
Nan Huang ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Resting State ◽  
Network Connectivity ◽  
Brain Network ◽  
Traumatic Experiences ◽  
First Episode ◽  
Resting State Networks ◽  
Attention Network ◽  
Brain Network Connectivity ◽  
First Episode Schizophrenia

Abstract Childhood trauma is a central risk factor for schizophrenia. We explored the correlation between early traumatic experiences and the functional connectivity of resting-state networks. This fMRI study included 28 first-episode schizophrenia patients and 27 healthy controls. In first-episode schizophrenia patients, higher levels of childhood trauma associated with abnormal connections of resting-state networks, and these anomalies distributed among task-positive networks (i.e., ventral attention network, dorsal-ventral attention network and frontal-parietal network), and sensory networks (i.e., visual network and auditory network). These findings mentioned that childhood traumatic experiences may impact resting-state network connectivity in adulthood, mainly involving systems related to attention and execution control.

scholarly journals Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis

2019 ◽  
Vol 45 (6) ◽  
pp. 1279-1290 ◽  
Author(s):  
Minji Bang ◽  
Jee In Kang ◽  
Se Joo Kim ◽  
Jin Young Park ◽  
Kyung Ran Kim ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Receptor Gene ◽  
Network Connectivity ◽  
Inverse Correlation ◽  
Brain Network ◽  
Oxytocin Receptor ◽  
Epigenetic Alterations ◽  
Oxytocin Receptor Gene ◽  
Recent Onset ◽  
Brain Network Connectivity

Abstract Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a key mechanism involved in social-emotional disturbances of schizophrenia. Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39 women), 46 UHR (19 women), and 98 healthy individuals (52 women) participated in this study. OXTR methylation was quantified using the pyrosequencing method. A subset of participants (16 ROS, 23 UHR, and 33 healthy controls [HCs]) underwent a 5.5-minute resting-state functional magnetic resonance imaging to determine the relationship between OXTR methylation and the striatal-amygdala network functional connectivity (FC) underlying anhedonia-asociality. Both men and women with ROS and UHR showed significantly decreased OXTR methylation compared to HCs. In women with ROS and UHR, decreased OXTR methylation showed a significant correlation with increased anhedonia-asociality. FC of the striatal-amygdala network, positively associated with the severity of anhedonia-asociality, showed an inverse correlation with OXTR methylation. This study suggests that epigenetic alterations of OXTR, which can be detected before the development of full-blown psychosis, confer susceptibility to schizophrenia and play a crucial role in the manifestation of anhedonia-asociality, particularly in women.

Sign in / Sign up

Export Citation Format

Share Document