Brain state-dependent recruitment of high-frequency oscillations in the human hippocampus

Cortex ◽  
2017 ◽  
Vol 94 ◽  
pp. 87-99 ◽  
Author(s):  
Pablo Billeke ◽  
Tomas Ossandon ◽  
Marcelo Stockle ◽  
Marcela Perrone-Bertolotti ◽  
Philippe Kahane ◽  
...  
Keyword(s):  
High Frequency ◽  
Brain State ◽  
High Frequency Oscillations ◽  
Human Hippocampus ◽  
State Dependent

State-dependent changes in high-frequency oscillations recorded in the rat nucleus accumbens

Neuroscience ◽  
2009 ◽  
Vol 164 (2) ◽  
pp. 380-386 ◽  
Author(s):  
M.J. Hunt ◽  
P. Matulewicz ◽  
C. Gottesmann ◽  
S. Kasicki
Keyword(s):  
Nucleus Accumbens ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
State Dependent ◽  
Rat Nucleus Accumbens

scholarly journals Propagation of Hippocampal Ripples to the Neocortex by Way of a Subiculum-Retrosplenial Pathway

2020 ◽  
Author(s):  
Noam Nitzan ◽  
Sam McKenzie ◽  
Prateep Beed ◽  
Daniel Fine English ◽  
Silvia Oldani ◽  
...  
Keyword(s):  
High Frequency ◽  
Activity Patterns ◽  
Retrosplenial Cortex ◽  
Brain State ◽  
Optogenetic Stimulation ◽  
Sharp Wave ◽  
State Dependent ◽  
High Frequency Activity ◽  
Underlying Mechanisms ◽  
Ensemble Activity

SUMMARYBouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.

scholarly journals The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Laura A Ewell ◽  
Kyle B Fischer ◽  
Christian Leibold ◽  
Stefan Leutgeb ◽  
Jill K Leutgeb
Keyword(s):  
High Frequency ◽  
Spatial Information ◽  
Spectral Characteristics ◽  
Field Potential ◽  
Therapeutic Interventions ◽  
Network Activity ◽  
Brain State ◽  
Chronic Epilepsy ◽  
High Frequency Oscillations ◽  
The Impact

In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as ‘ripple-like’ or ‘pHFO’. We compared their spectral characteristics, brain state dependence, and cellular participants. Strikingly, pHFO occurred irrespective of brain state, were associated with interictal spikes, engaged distinct subnetworks of principal neurons compared to ripple-like events, increased the sparsity of network activity, and initiated both general and immediate disruptions in spatial information coding. Taken together, our findings suggest that events that result in pHFOs have an immediate impact on memory processes, corroborating the need for proper classification of pHFOs to facilitate therapeutic interventions that selectively target pathological activity.

Role of low- and high-frequency oscillations in the human hippocampus for encoding environmental novelty during a spatial navigation task

Hippocampus ◽  
2014 ◽  
Vol 24 (11) ◽  
pp. 1341-1352 ◽  
Author(s):  
Jinsick Park ◽  
Hojong Lee ◽  
Taekyung Kim ◽  
Ga Young Park ◽  
Eun Mi Lee ◽  
...  
Keyword(s):  
High Frequency ◽  
Spatial Navigation ◽  
Navigation Task ◽  
High Frequency Oscillations ◽  
Human Hippocampus ◽  
Environmental Novelty

scholarly journals Can we use intraoperative high‐frequency oscillations to guide tumor‐related epilepsy surgery?

Epilepsia ◽  
2021 ◽  
Author(s):  
Nicole E. C. Klink ◽  
Willemiek J. E. M. Zweiphenning ◽  
Cyrille H. Ferrier ◽  
Peter H. Gosselaar ◽  
Kai J. Miller ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
High Frequency Oscillations

scholarly journals High-frequency oscillations recorded with surface EEG in neonates with seizures

2021 ◽  
Author(s):  
Lotte Noorlag ◽  
Maryse A. van 't Klooster ◽  
Alexander C. van Huffelen ◽  
Nicole E.C. van Klink ◽  
Manon J.N.L. Benders ◽  
...  
Keyword(s):  
High Frequency ◽  
High Frequency Oscillations ◽  
Surface Eeg
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