scholarly journals Can we use intraoperative high‐frequency oscillations to guide tumor‐related epilepsy surgery?

Epilepsia ◽  
2021 ◽  
Author(s):  
Nicole E. C. Klink ◽  
Willemiek J. E. M. Zweiphenning ◽  
Cyrille H. Ferrier ◽  
Peter H. Gosselaar ◽  
Kai J. Miller ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
High Frequency Oscillations

scholarly journals High-frequency oscillations in scalp EEG mirror seizure frequency in pediatric focal epilepsy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ece Boran ◽  
Johannes Sarnthein ◽  
Niklaus Krayenbühl ◽  
Georgia Ramantani ◽  
Tommaso Fedele
Keyword(s):  
Seizure Frequency ◽  
Epilepsy Surgery ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Low Noise ◽  
Drug Resistant ◽  
Scalp Eeg ◽  
High Frequency Oscillations ◽  
Custom Made ◽  
Active Epilepsy

Abstract High-frequency oscillations (HFO) are promising EEG biomarkers of epileptogenicity. While the evidence supporting their significance derives mainly from invasive recordings, recent studies have extended these observations to HFO recorded in the widely accessible scalp EEG. Here, we investigated whether scalp HFO in drug-resistant focal epilepsy correspond to epilepsy severity and how they are affected by surgical therapy. In eleven children with drug-resistant focal epilepsy that underwent epilepsy surgery, we prospectively recorded pre- and postsurgical scalp EEG with a custom-made low-noise amplifier (LNA). In four of these children, we also recorded intraoperative electrocorticography (ECoG). To detect clinically relevant HFO, we applied a previously validated automated detector. Scalp HFO rates showed a significant positive correlation with seizure frequency (R2 = 0.80, p < 0.001). Overall, scalp HFO rates were higher in patients with active epilepsy (19 recordings, p = 0.0066, PPV = 86%, NPV = 80%, accuracy = 84% CI [62% 94%]) and decreased following successful epilepsy surgery. The location of the highest HFO rates in scalp EEG matched the location of the highest HFO rates in ECoG. This study is the first step towards using non-invasively recorded scalp HFO to monitor disease severity in patients affected by epilepsy.

scholarly journals Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients

2020 ◽  
Vol 134 ◽  
pp. 104618 ◽  
Author(s):  
Carlos Cepeda ◽  
Simon Levinson ◽  
Hiroki Nariai ◽  
Vannah-Wila Yazon ◽  
Conny Tran ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
Synaptic Activity ◽  
Pediatric Epilepsy ◽  
High Frequency Oscillations ◽  
Pediatric Epilepsy Surgery

scholarly journals Blinded study: prospectively defined high frequency oscillations predict seizure outcome in individual patients

2020 ◽  
Author(s):  
V Dimakopoulos ◽  
P Mégevand ◽  
E Boran ◽  
S Momjian ◽  
M Seeck ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
Dwell Time ◽  
Nrem Sleep ◽  
Seizure Outcome ◽  
Seizure Freedom ◽  
University Hospitals ◽  
High Frequency Oscillations ◽  
Depth Electrodes

AbstractBackgroundInterictal high frequency oscillations (HFO) are discussed as biomarkers for epileptogenic brain tissue that should be resected in epilepsy surgery to achieve seizure freedom. The prospective classification of tissue sampled by individual electrode contacts remains a challenge. We have developed an automated, prospective definition of clinically relevant HFO in intracranial EEG (iEEG) from MNI Montreal and tested it in iEEG from Zurich. We here validate the algorithm on iEEG recorded in an independent epilepsy center so that HFO analysis was blinded to seizure outcome.MethodsWe selected consecutive patients from Geneva University Hospitals who underwent resective epilepsy surgery with postsurgical follow-up > 12 months. We analyzed long-term iEEG recordings during non-rapid eye movement (NREM) sleep that we segmented into intervals of 5 min. HFOs were defined in the ripple (80-250 Hz) and the fast ripple (FR, 250-500 Hz) frequency band. Contacts with the highest rate of ripples co-occurring with FR (FRandR) designated the HFO area. If the HFO area was not fully resected and the patient suffered from recurrent seizures (ILAE 2-6), this was classified as a true positive (TP) prediction.ResultsWe included iEEG recordings from 16 patients (median age 32 y, range [18-53]) with stereotactic depth electrodes and/or with subdural electrode grids (median follow-up 27 mo, range [12-55]). The HFO area had high test-retest reliability across intervals (median dwell time 95%). We excluded two patients with dwell time < 50% from further analysis.The HFO area was fully included in the resected volume in 2/4 patients who achieved postoperative seizure freedom (ILAE 1, specificity 50%) and was not fully included in 9/10 patients with recurrent seizures (ILAE > 1, sensitivity 90%), leading to an accuracy of 79%.ConclusionsWe validated the automated procedure to delineate the clinical relevant HFO area in individual patients of an independently recorded dataset and achieved the same good accuracy as in our previous studies.SignificanceThe reproducibility of our results across datasets is promising for a multicienter study testing the clinical application of HFO detection to guide epilepsy surgery.

High-Frequency Oscillations Versus Spikes in Intraoperative Electrocorticography to Tailor Epilepsy Surgery: The Randomized Controlled, Single-Blinded, Non-Inferiority, HFO Trial

2021 ◽  
Author(s):  
Willemiek Zweiphenning ◽  
Maryse A. van 't Klooster ◽  
Nicole E.C. van Klink ◽  
Frans S.S. Leijten ◽  
Cyrille H. Ferrier ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
Randomized Controlled ◽  
High Frequency Oscillations

scholarly journals Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xiaoming Yan ◽  
Fangzhao Yin ◽  
Cuiping Xu ◽  
Tao Yu ◽  
Xiaonan Li ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
High Frequency ◽  
Multimodal Imaging ◽  
Prognostic Value ◽  
Imaging Methods ◽  
High Frequency Oscillations
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