Altered hemispheric lateralization of white matter pathways in developmental dyslexia: Evidence from spherical deconvolution tractography

Cortex ◽  
2016 ◽  
Vol 76 ◽  
pp. 51-62 ◽  
Author(s):  
Jingjing Zhao ◽  
Michel Thiebaut de Schotten ◽  
Irene Altarelli ◽  
Jessica Dubois ◽  
Franck Ramus
Keyword(s):  
White Matter ◽  
Developmental Dyslexia ◽  
Hemispheric Lateralization ◽  
Spherical Deconvolution

scholarly journals Evaluating the performance of 3-tissue constrained spherical deconvolution pipelines for within-tumor tractography

2019 ◽  
Author(s):  
Hannelore Aerts ◽  
Thijs Dhollander ◽  
Daniele Marinazzo
Keyword(s):  
White Matter ◽  
Tumor Tissue ◽  
Diffusion Tensor ◽  
Orientation Distribution ◽  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution ◽  
Fiber Orientation Distribution ◽  
Tissue Compartments ◽  
Diffusion Tensor Imaging Dti ◽  
Single Shell

AbstractThe use of diffusion MRI (dMRI) for assisting in the planning of neurosurgery has become increasingly common practice, allowing to non-invasively map white matter pathways via tractography techniques. Limitations of earlier pipelines based on the diffusion tensor imaging (DTI) model have since been revealed and improvements were made possible by constrained spherical deconvolution (CSD) pipelines. CSD allows to resolve a full white matter (WM) fiber orientation distribution (FOD), which can describe so-called “crossing fibers”: complex local geometries of WM tracts, which DTI fails to model. This was found to have a profound impact on tractography results, with substantial implications for presurgical decision making and planning. More recently, CSD itself has been extended to allow for modeling of other tissue compartments in addition to the WM FOD, typically resulting in a 3-tissue CSD model. It seems likely this may improve the capability to resolve WM FODs in the presence of infiltrating tumor tissue. In this work, we evaluated the performance of 3-tissue CSD pipelines, with a focus on within-tumor tractography. We found that a technique named single-shell 3-tissue CSD (SS3T-CSD) successfully allowed tractography within infiltrating gliomas, without increasing existing single-shell dMRI acquisition requirements.

scholarly journals White matter microstructure of the extended limbic system in male and female youth with conduct disorder

2019 ◽  
Vol 50 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Karen González-Madruga ◽  
Jack Rogers ◽  
Nicola Toschi ◽  
Roberta Riccelli ◽  
Areti Smaragdi ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Conduct Disorder ◽  
Limbic System ◽  
Structural Connectivity ◽  
Imaging Data ◽  
Spherical Deconvolution ◽  
Weighted Magnetic Resonance Imaging ◽  
The Right ◽  
And Control

AbstractBackgroundPrevious studies of conduct disorder (CD) have reported structural and functional alterations in the limbic system. However, the white matter tracts that connect limbic regions have not been comprehensively studied. The uncinate fasciculus (UF), a tract connecting limbic to prefrontal regions, has been implicated in CD. However, CD-related alterations in other limbic tracts, such as the cingulum and the fornix, have not been investigated. Furthermore, few studies have examined the influence of sex and none have been adequately powered to test whether the relationship between CD and structural connectivity differs by sex. We examined whether adolescent males and females with CD exhibit differences in structural connectivity compared with typically developing controls.MethodsWe acquired diffusion-weighted magnetic resonance imaging data from 101 adolescents with CD (52 females) and 99 controls (50 females). Data were processed for deterministic spherical deconvolution tractography. Virtual dissections of the UF, the three subdivisions of the cingulum [retrosplenial cingulum (RSC), parahippocampal and subgenual cingulum], and the fornix were performed and measures of fractional anisotropy (FA) and hindrance-modulated orientational anisotropy (HMOA) were analysed.ResultsThe CD group had lower FA and HMOA in the right RSC tract relative to controls. Importantly, these effects were moderated by sex – males with CD significantly lower FA compared to male controls, whereas CD and control females did not differ.ConclusionsOur results highlight the importance of considering sex when studying the neurobiological basis of CD. Sex differences in RSC connectivity may contribute to sex differences in the clinical presentation of CD.

scholarly journals White Matter Alterations in Infants at Risk for Developmental Dyslexia

2015 ◽  
pp. bhv281 ◽  
Author(s):  
Nicolas Langer ◽  
Barbara Peysakhovich ◽  
Jennifer Zuk ◽  
Marie Drottar ◽  
Danielle D. Sliva ◽  
...  
Keyword(s):  
At Risk ◽  
White Matter ◽  
Developmental Dyslexia

scholarly journals White Matter Tissue Quantification at Low b-Values Within Constrained Spherical Deconvolution Framework

2018 ◽  
Vol 9 ◽  
Author(s):  
Alessandro Calamuneri ◽  
Alessandro Arrigo ◽  
Enricomaria Mormina ◽  
Demetrio Milardi ◽  
Alberto Cacciola ◽  
...  
Keyword(s):  
White Matter ◽  
B Values ◽  
Constrained Spherical Deconvolution ◽  
Spherical Deconvolution ◽  
Tissue Quantification

scholarly journals Disrupted white matter connectivity underlying developmental dyslexia: A machine learning approach

2016 ◽  
Vol 37 (4) ◽  
pp. 1443-1458 ◽  
Author(s):  
Zaixu Cui ◽  
Zhichao Xia ◽  
Mengmeng Su ◽  
Hua Shu ◽  
Gaolang Gong
Keyword(s):  
Machine Learning ◽  
White Matter ◽  
Developmental Dyslexia ◽  
Learning Approach ◽  
Machine Learning Approach ◽  
White Matter Connectivity

Simple Developmental Dyslexia in Children: Alterations in Diffusion-Tensor Metrics of White Matter Tracts at 3 T

Radiology ◽  
2009 ◽  
Vol 251 (3) ◽  
pp. 882-891 ◽  
Author(s):  
Nancy K. Rollins ◽  
Behroze Vachha ◽  
Priya Srinivasan ◽  
Jonathon Chia ◽  
Joyce Pickering ◽  
...  
Keyword(s):  
White Matter ◽  
Developmental Dyslexia ◽  
Diffusion Tensor ◽  
White Matter Tracts
Sign in / Sign up

Export Citation Format

Share Document