Systems analysis of adaptive immunity by utilization of high-throughput technologies

2011 ◽  
Vol 22 (4) ◽  
pp. 584-589 ◽  
Author(s):  
Sai T Reddy ◽  
George Georgiou
Keyword(s):  
Adaptive Immunity ◽  
High Throughput ◽  
Systems Analysis

scholarly journals Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data

2020 ◽  
Vol 11 ◽  
Author(s):  
Jun Min ◽  
Mylarappa Ningappa ◽  
Juhoon So ◽  
Donghun Shin ◽  
Rakesh Sindhi ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
High Throughput ◽  
Systems Analysis ◽  
Biological Data

scholarly journals Quantifying lymphocyte receptor diversity

2016 ◽  
Author(s):  
Thierry Mora ◽  
Aleksandra M. Walczak
Keyword(s):  
T Lymphocytes ◽  
Adaptive Immunity ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Sequencing Data ◽  
Somatic Evolution ◽  
High Throughput Sequencing Data ◽  
Relevant Notion ◽  
Inference Methods ◽  
B And T Lymphocytes

To recognize pathogens, B and T lymphocytes are endowed with a wide repertoire of receptors generated stochastically by V(D)J recombination. Measuring and estimating the diversity of these receptors is of great importance for understanding adaptive immunity. In this chapter we review recent modeling approaches for analyzing receptor diversity from high-throughput sequencing data. We first clarify the various existing notions of diversity, with its many competing mathematical indices, and the different biological levels at which it can be evaluated. We then describe inference methods for characterizing the statistical diversity of receptors at different stages of their history: generation, selection and somatic evolution. We discuss the intrinsic difficulty of estimating the diversity of receptors realized in a given individual from incomplete samples. Finally, we emphasize the limitations of diversity defined at the level of receptor sequences, and advocate the more relevant notion of functional diversity relative to the set of recognized antigens.

scholarly journals Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing

2021 ◽  
Vol 12 ◽  
Author(s):  
Binyao Chen ◽  
Lei Zhu ◽  
Shizhao Yang ◽  
Wenru Su
Keyword(s):  
Dendritic Cells ◽  
Single Cell ◽  
Rna Sequencing ◽  
Adaptive Immunity ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Future Trends ◽  
Innate And Adaptive Immunity ◽  
Sequencing Technologies ◽  
Single Cell Rna Sequencing

Dendritic cells (DCs) play essential roles in innate and adaptive immunity and show high heterogeneity and intricate ontogeny. Advances in high-throughput sequencing technologies, particularly single-cell RNA sequencing (scRNA-seq), have improved the understanding of DC subsets. In this review, we discuss in detail the remarkable perspectives in DC reclassification and ontogeny as revealed by scRNA-seq. Moreover, the heterogeneity and multifunction of DCs during diseases as determined by scRNA-seq are described. Finally, we provide insights into the challenges and future trends in scRNA-seq technologies and DC research.

scholarly journals Tissue matrix arrays for high-throughput screening and systems analysis of cell function

2015 ◽  
Vol 12 (12) ◽  
pp. 1197-1204 ◽  
Author(s):  
Vince Z Beachley ◽  
Matthew T Wolf ◽  
Kaitlyn Sadtler ◽  
Srikanth S Manda ◽  
Heather Jacobs ◽  
...  
Keyword(s):  
High Throughput ◽  
Systems Analysis ◽  
High Throughput Screening ◽  
Cell Function ◽  
Tissue Matrix ◽  
Matrix Arrays

154: Integration of TPSA and High-Throughput Mass Spectrometry Data Improves Prostate Cancer Prediction

2007 ◽  
Vol 177 (4S) ◽  
pp. 52-53
Author(s):  
Stefano Ongarello ◽  
Eberhard Steiner ◽  
Regina Achleitner ◽  
Isabel Feuerstein ◽  
Birgit Stenzel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mass Spectrometry ◽  
High Throughput ◽  
Mass Spectrometry Data ◽  
Cancer Prediction
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