Reduced community access to a key contraceptive: public health consequence from false suspicion of HIV-contaminated injectables

Contraception ◽  
2010 ◽  
Vol 82 (3) ◽  
pp. 296-300
Author(s):  
David W. Jenkins ◽  
Robert Krysiak ◽  
Connie Sexton
Keyword(s):  
Public Health ◽  
Health Consequence ◽  
Community Access

scholarly journals A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

2021 ◽  
Author(s):  
Hongbo Liu ◽  
Xiang Gao ◽  
Guoyong Wang ◽  
Jianjun Zhang ◽  
Jiajie Zhou ◽  
...  
Keyword(s):  
Public Health ◽  
Recombinant Protein ◽  
Global Economy ◽  
Neutralizing Antibody ◽  
Scaling Up ◽  
Heptad Repeat ◽  
The Novel ◽  
Health Consequence ◽  
The World ◽  
Frequent Mutations

The COVID-19 pandemic and the continued spreading of the SARS-CoV-2 variants have brought a grave public health consequence and severely devastated the global economy with recessions. Vaccination is considered as one of the most promising and efficient methods to end the COVID-19 pandemic and mitigate the disease conditions if infected. Although a few vaccines have been developed with an unprecedented speed, scientists around the world are continuing pursuing the best possible vaccines with innovations. Comparing to the expensive mRNA vaccines and attenuated/inactivated SARS-CoV-2 vaccines, recombinant protein vaccines have certain advantages, including their safety (non-virus components), potential stronger immunogenicity, broader protection, ease of scaling-up production, reduced cost, etc. In this study, we reported a novel COVID-19 vaccine generated with RBD-HR1/HR2 hexamer that was creatively fused with the RBD domain and heptad repeat 1 (HR1) or heptad repeat 2 (HR2) to form a dumbbell-shaped hexamer to target the spike S1 subunit. The novel hexamer COVID-19 vaccine induced high titers of neutralizing antibody in mouse studies (>100,000), and further experiments also showed that the vaccine also induced an alternative antibody to the HR1 region, which probably alleviated the drop of immunogenicity from the frequent mutations of SARS-CoV-2.

Evaluation of the Community Access to Child Health Program

PEDIATRICS ◽  
1999 ◽  
Vol 103 (Supplement_4) ◽  
pp. 1384-1393
Author(s):  
Cynthia Minkovitz ◽  
Holly Grason ◽  
Barbara Aliza ◽  
Vince Hutchins ◽  
Lucia Rojas-Smith ◽  
...  
Keyword(s):  
Public Health ◽  
Child Health ◽  
Child Health Services ◽  
Minority Population ◽  
Project Staff ◽  
Community Factors ◽  
Public Health Agencies ◽  
Attitudinal Barriers ◽  
Negative Perceptions ◽  
Community Access

Objective. Increasing attention is being focused on the need for pediatricians to promote child health in their respective communities. The objective of this study was to evaluate, retrospectively, the American Academy of Pediatrics' Community Access to Child Health (CATCH) Program. Study Design. Case studies of 12 Community Pediatric projects in existence from 1989 to 1995 with varying degrees of involvement in the CATCH Program. In-person interviews were conducted with 17 pediatricians, 3 CATCH leaders who were not pediatricians, 27 project advisory committee members, 42 project staff, 47 community partners, 22 public health representatives, and personnel in 13 affiliated institutions. Results. These projects established or enhanced child health services. Although most pediatricians' interest in community child health preceded CATCH, mentoring, training, and peer support contributed to ongoing involvement. Community factors that facilitated project development included historical collaborative efforts and active public health agencies. However, across sites, significant barriers related to attitude and resource limitations were noted. Attitudinal barriers included both institutional concerns (eg, competition among providers or distrust among community agencies and organizations) and cultural concerns (eg, general negative perceptions of providers about Medicaid beneficiaries or of members of minority population toward medical or government establishments). Conclusions. In an era of devolution of responsibility to local communities, there are likely to be more opportunities for pediatricians to work with community members to promote child health. Specific strategies should be refined and expanded to support pediatricians' involvement in community-based activities, particularly because it is recognized that insurance alone will not guarantee children's health.

Public Health and Newborn Hearing Screening

1997 ◽  
Vol 6 (1) ◽  
pp. 11-16
Author(s):  
Terrey Oliver Penn ◽  
Susan E. Abbott
Keyword(s):  
Public Health ◽  
Hearing Screening ◽  
Newborn Hearing Screening ◽  
Newborn Hearing
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