scholarly journals Comparison of efficacy and safety of two available natural surfactants in Iran, Curosurf and Survanta in treatment of neonatal respiratory distress syndrome: A randomized clinical trial

2016 ◽  
Vol 3 ◽  
pp. 55-59 ◽  
Author(s):  
Bita Najafian ◽  
Hamidreza Karimi-Sari ◽  
Mohammad Hossein Khosravi ◽  
Niloofar Nikjoo ◽  
Sobhan Amin ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Randomized Clinical Trial ◽  
Distress Syndrome ◽  
Neonatal Respiratory Distress Syndrome ◽  
Efficacy And Safety ◽  
Neonatal Respiratory Distress ◽  
Natural Surfactants

Prevention of Neonatal Respiratory Distress Syndrome by Tracheal Instillation of Surfactant: A Randomized Clinical Trial

PEDIATRICS ◽  
1985 ◽  
Vol 76 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Goran Enhorning ◽  
Andrew Shennan ◽  
Fred Possmayer ◽  
Michael Dunn ◽  
Chee P. Chen ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Randomized Clinical Trial ◽  
Distress Syndrome ◽  
Ventilatory Support ◽  
Peak Inspiratory Pressure ◽  
Lung Lavage ◽  
Neonatal Respiratory Distress Syndrome ◽  
Neonatal Respiratory Distress

With a randomized clinical trial, the possibility was assessed that a tracheal instillation of pulmonary surfactant prior to the first breath might prevent the development of some of the signs of neonatal respiratory distress syndrome. Of the 72 infants in the trial, all born at a gestational age of less than 30 weeks, 39 received 3 or 4 mL of surfactant, prepared from the lipids extracted from calf lung lavage. The treatment resulted in a significantly improved gas exchange during the first 72 hours of life. On the average, the arterial/alveolar Po2 ratio was 0.15 higher for the treated infants, and only about half as much extra oxygen had to be supplied. The respiratory support (peak inspiratory pressure x frequency) could be lowered significantly. Pulmonary interstitial emphysema occurred in 13 of the 33 control infants, but in only three of the 39 treated infants. Six of the control infants died in the neonatal period, but only one treated infant died. It is concluded that surfactant supplementation prior to the first breath is feasible and is of value as protection against the respiratory distress syndrome and the negative effects of hypoxia and ventilatory support.

Aerosolized surfactant in neonatal respiratory distress syndrome: Phase I study

2019 ◽  
Vol 134 ◽  
pp. 19-25 ◽  
Author(s):  
Beena G. Sood ◽  
Josef Cortez ◽  
Madhuri Kolli ◽  
Amit Sharma ◽  
Virginia Delaney-Black ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Phase I ◽  
Phase I Study ◽  
Distress Syndrome ◽  
Neonatal Respiratory Distress Syndrome ◽  
Neonatal Respiratory Distress
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