Efficacy and safety of surfactant administration via thin catheter in preterm infants with neonatal respiratory distress syndrome: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Xiaohong Wu ◽  
Zhoushan Feng ◽  
Juan Kong ◽  
Yiyu Lai ◽  
Chunhong Jia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Distress Syndrome ◽  
Meta Analysis ◽  
Neonatal Respiratory Distress Syndrome ◽  
Efficacy And Safety ◽  
Neonatal Respiratory Distress ◽  
Surfactant Administration

scholarly journals Efficacy and safety of minimally invasive surfactant administration in preterm infants with neonatal respiratory distress syndrome: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xiao Hong Wu ◽  
Zhoushan Feng ◽  
Juan Kong ◽  
Yiyu Lai ◽  
Chunhong Jia ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Minimally Invasive ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Distress Syndrome ◽  
Meta Analysis ◽  
Control Group ◽  
Neonatal Respiratory Distress ◽  
Surfactant Administration

Abstract Background: The effects of minimally invasive surfactant administration (MISA) in preterm infants with neonatal respiratory distress syndrome (NRDS) are unclear. Methods: We searched randomized controlled trials (RCTs) and compared MISA techniques with intubation for surfactant delivery in preterm infants with NRDS in PubMed, Embase, Cochrane Library, and Web of Science. Results: Thirteen RCTs (1931 infants) were included in the meta-analysis. The use of MISA techniques decrease the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks, pneumothorax, and hemodynamically significant patent ductus arteriosus (hsPDA) (Risk Ratio(RR) : 0.59, 95% confidence interval (CI) : 0.46 to 0.75, p < .0001; RR : 0.60, 95% CI : 0.39 to 0.93, p= .02 and RR : 0.88, 95% CI : 0.78 to 1.00, p= .04, respectively). In addition, infants in the MISA group required less mechanical ventilation within 72 h of life or during hospitalization (RR : 0.60, 95% CI : 0.48 to 0.75, p< .00001 and RR : 0.64, 95% CI : 0.49 to 0.82, p = .0005, respectively) compared with infants in the control group. However, the rate of surfactant reflux was higher in the MISA group than that in the control group (RR : 2.12, 95% CI : 1.37 to 3.29, p = .0008). There were no significant differences in mortality and other outcomes beteween the MISA group and the control group. Conclusions: The administration of surfactant with MISA techniques could lower the requirement for mechanical ventilation, and decrease the incidence of BPD at 36 weeks, pneumothorax, and hsPDA.

scholarly journals Diagnostic value of lung ultrasound for neonatal respiratory distress syndrome: a meta-analysis and systematic review

2020 ◽  
Vol 22 (3) ◽  
pp. 325 ◽  
Author(s):  
HaiRan Ma ◽  
WenKang Yan ◽  
Jing Liu
Keyword(s):  
Systematic Review ◽  
Respiratory Distress Syndrome ◽  
Diagnostic Accuracy ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Lung Ultrasound ◽  
Meta Analysis ◽  
Neonatal Respiratory Distress Syndrome ◽  
Current Evidence ◽  
Neonatal Respiratory Distress

Aim: Neonatal respiratory distress syndrome (NRDS) is one of the most common and severe diseases in neonatal intensive care units worldwide. Increasing evidence suggests that lung ultrasound (LUS) may be a reliable diagnostic tool for neonatal respiratory distress syndrome. The aim of study was to evaluate the diagnostic accuracy of LUS for NRDS with a systematic review and meta-analysis.Material and methods: We searched for articles in EMBASE, PubMed and Cochrane Central from inception until 17 August 2019. The selected studies were diagnostic accuracy studies that reported the utility of LUS in the diagnosis of NRDS. Two researchers independently extracted data and assessed quality using the QUADAS-2 tool. Then, we created a bivariate mixed effects model to calculate the sensitivity and specificity of LUS in diagnosing NRDS. A summary receiver operator characteristic (SROC) curve was constructed to summarize the performance characteristics of LUS.Results: Nine studies involving 703 infants were included in the review. LUS had a pooled sensitivity of 0.99 (CI: 0.92-1.00) and a specificity of 0.95 (CI: 0.87-0.98). The areas under the curve for LUS was 0.99 (0.98-1.0). Meta-regression revealed that LUS had a significant diagnostic accuracy for NRDS.Conclusion: LUS is a promising method that is easily carried out, inexpensive, nonionizing and repeatable and can be performed at the bedside. Current evidence supports LUS as a useful imaging alternative for the diagnosis of NRDS.

scholarly journals Lung ultrasound in diagnosing neonatal respiratory distress syndrome: a meta-analysis

2019 ◽  
Vol 59 (6) ◽  
pp. 340-8
Author(s):  
Hanum Ferdian ◽  
Dian Ibnu Wahid ◽  
Samad Samad ◽  
Anggun Esti Wardani ◽  
Guntur Surya Alam ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Sensitivity And Specificity ◽  
Diagnostic Tool ◽  
Distress Syndrome ◽  
Lung Ultrasound ◽  
Meta Analysis ◽  
Neonatal Respiratory Distress Syndrome ◽  
Inclusion Criteria ◽  
Neonatal Respiratory Distress

Background Neonatal respiratory distress syndrome (NRDS) is commonly diagnosed by clinical sign and symptoms, blood gas analysis, and chest x-ray. In the past, lung ultrasound (LUS) was not standard for NRDS examination. Many studies show that ultrasound diagnostic tool for NRDS is accurate, reliable, low cost, easy to use, and safe because due to no ionizing radiation. Objective To determine the sensitivity and specificity of LUS in diagnosing NRDS. Methods This meta-analysis study was conducted LUS as a diagnostic tool for NRDS. Inclusion criteria were all studies from PubMed, Embase, and The Cochrane Library, without any limitation on published journals, as well as using keywords or search terms of ultrasound, neonatal, and respiratory distress syndrome. Statistical analysis was undertaken using MedCalc® version 18.2 software. Results Seven studies with a total of 580 patients met the inclusion criteria. Proportional meta-analysis obtained random effects models, with total sensitivity of LUS was 97.2% (95% CI for I2 74.24 to 92.88; P<0.0001) and specificity of LUS was 94.8% (95% CI for I2 88.60 to 98.03; P<0.00001). Conclusion Lung ultrasound should be considered as a diagnostic tool for NRDS because it is high in sensitivity and specificity, inexpensive, safe, as well as limited radiation exposure.

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