Clinically related or predictive factors and impacts on long-term treatment outcomes of involvement behaviors in patients with obsessive–compulsive disorder

2015 ◽  
Vol 60 ◽  
pp. 105-113 ◽  
Author(s):  
Yoshinobu Yanagisawa ◽  
Naomi Matsuura ◽  
Keiichiro Mukai ◽  
Akihiro Nakajima ◽  
Mikuni Motoyama ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Obsessive Compulsive Disorder ◽  
Predictive Factors ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Treatment

Weight Gain During Long-Term Treatment of Obsessive-Compulsive Disorder

2004 ◽  
Vol 65 (10) ◽  
pp. 1365-1371 ◽  
Author(s):  
Giuseppe Maina ◽  
Umberto Albert ◽  
Virginio Salvi ◽  
Filippo Bogetto
Keyword(s):  
Weight Gain ◽  
Obsessive Compulsive Disorder ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Treatment

scholarly journals Deep Brain Stimulation for Major Depression and Obsessive-Compulsive Disorder—Discontinuation of Ongoing Stimulation

Psych ◽  
2020 ◽  
Vol 2 (3) ◽  
pp. 174-185
Author(s):  
Hannah M. Kilian ◽  
Bettina H. Bewernick ◽  
Margaretha Klein ◽  
Dora M. Meyer ◽  
Susanne Spanier ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Long Term Treatment ◽  
Deep Brain

Deep brain stimulation (DBS) is currently under research for the treatment of psychiatric disorders, e.g., obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). Since the application of DBS in psychiatry has been in use for about 20 years, it is necessary to evaluate its long-term use now. A main issue in the long-term treatment of DBS concerns the effects of a discontinuation of stimulation due to intended as well as unintended reasons. In this contribution, the literature describing discontinuation effects following DBS in OCD and TRD is reviewed. Furthermore, a patient is reported in depth who experienced an unintended discontinuation of supero-lateral medial forebrain bundle (slMFB) DBS for TRD. In this case, the battery was fully depleted without the patient noticing. DBS had led to a sustained response for seven years before discontinuation of stimulation for just several weeks caused a progressive worsening of depression. Altogether, the rapid occurrence of symptom worsening, the absence of a notification about the stimulation status and the difficulties to recapture antidepressant response represent important safety aspects. For a further understanding of the described effects, time courses until worsening of depression as well as biological mechanisms need to be investigated in double-blind controlled trials.

Acute and Long-Term Treatment and Prevention of Relapse of Obsessive-Compulsive Disorder With Paroxetine

2003 ◽  
Vol 64 (9) ◽  
pp. 1113-1121 ◽  
Author(s):  
Eric Hollander ◽  
Andrea Allen ◽  
Martin Steiner ◽  
David E. Wheadon ◽  
Rosemary Oakes ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment And Prevention ◽  
Long Term Treatment ◽  
Prevention Of Relapse

Efficacy of Sertraline in the Long-Term Treatment of Obsessive-Compulsive Disorder

2002 ◽  
Vol 159 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Lorrin M. Koran ◽  
Elizabeth Hackett ◽  
Arkady Rubin ◽  
Robert Wolkow ◽  
Delbert Robinson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Treatment

WCA Recommendations for the Long-Term Treatment of Obsessive-Compulsive Disorder in Adults

CNS Spectrums ◽  
2003 ◽  
Vol 8 (S1) ◽  
pp. 7-16 ◽  
Author(s):  
John H. Greist ◽  
Borwin Bandelow ◽  
Eric Hollander ◽  
Donatella Marazziti ◽  
Stuart A. Montgomery ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Treatment Guidelines ◽  
Term Treatment ◽  
Tricyclic Antidepressant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment Trials ◽  
Long Term Treatment

ABSTRACTWhat are the latest psychotherapeutic and pharmacotherapeutic treatment recommendations for obsessive-compulsive disorder (OCD)? OCD is a relatively common disorder with a lifetime prevalence of ~2% in the general population. It often has an early onset, usually in childhood or adolescence, and frequently becomes chronic and disabling if left untreated. High associated healthcare utilization and costs, and reduced productivity resulting in loss of earning, pose a huge economic burden to OCD patients and their families, employers, and society. OCD is characterized by the presence of obsessions and compulsions that are time-consuming, cause marked distress, or significantly interfere with a person's functioning. Most patients with OCD experience symptoms throughout their lives and benefit from long-term treatment. Both psychotherapy and pharmacotherapy are recommended, either alone or in combination, for the treatment of OCD. Cognitive-behavioral therapy is the psychotherapy of choice. Pharmacologic treatment options include the tricyclic antidepressant clomipramine and the selective serotonin reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. These have all shown benefit in acute treatment trials; clomipramine, fluvoxamine, fluoxetine, and sertraline have also demonstrated benefit in long-term treatment trials (at least 24 weeks), and clomipramine, sertraline, and fluvoxamine have United States Food and Drug Administration approvals for use in children and adolescents. Available treatment guidelines recommend first-line use of an SSR1 (ie, fluoxetine, fluvoxamine, paroxetine, sertraline, or citalopram) in preference to clomipramine, due to the latter's less favorable adverse-event profile. Further, pharmacotherapy for a minimum of 1–2 years is recommended before very gradual withdrawal may be considered.

Long Term Treatment of Obsessive-Compulsive Disorder

CNS Drugs ◽  
1998 ◽  
Vol 10 (4) ◽  
pp. 247-255 ◽  
Author(s):  
Luigi Ravizza ◽  
Giuseppe Maina ◽  
Filippo Bogetto ◽  
Umberto Albert ◽  
Giulio Barzega ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Treatment
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