Adverse childhood experiences and gender influence treatment seeking behaviors in obsessive–compulsive disorder

2014 ◽  
Vol 55 (2) ◽  
pp. 298-301 ◽  
Author(s):  
Francesco Benedetti ◽  
Sara Poletti ◽  
Daniele Radaelli ◽  
Elena Pozzi ◽  
Chiara Giacosa ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Adverse Childhood Experiences ◽  
Treatment Seeking ◽  
Obsessive Compulsive ◽  
Childhood Experiences ◽  
Compulsive Disorder ◽  
Gender Influence ◽  
Adverse Childhood ◽  
And Gender

scholarly journals Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses

2020 ◽  
Vol 54 (11) ◽  
pp. 1086-1094
Author(s):  
Amala Someshwar ◽  
Bharath Holla ◽  
Preeti Pansari Agarwal ◽  
Anza Thomas ◽  
Anand Jose ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Adverse Childhood Experiences ◽  
Substance Dependence ◽  
Age Of Onset ◽  
Obsessive Compulsive ◽  
Childhood Experiences ◽  
Compulsive Disorder ◽  
First Degree Relatives ◽  
Adverse Childhood ◽  
Psychiatric Conditions

Objective: Adverse childhood experiences are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of adverse childhood experiences and their relation to the age of onset of major psychiatric conditions in individuals from families that had ⩾2 first-degree relatives with major psychiatric conditions (multiplex families), identified as part of an ongoing longitudinal study. Methods: Our sample consisted of 509 individuals from 215 families. Of these, 268 were affected, i.e., diagnosed with bipolar disorder ( n = 61), obsessive–compulsive disorder ( n = 58), schizophrenia ( n = 52), substance dependence ( n = 59) or co-occurring diagnoses ( n = 38), while 241 were at-risk first-degree relatives who were either unaffected ( n = 210) or had other depressive or anxiety disorders ( n = 31). All individuals were evaluated using the Adverse Childhood Experiences – International Questionnaire and total adverse childhood experiences exposure and severity scores were calculated. Results: It was seen that affected males, as a group, had the greatest adverse childhood experiences exposure and severity scores in our sample. A Cox mixed effects model fit by gender revealed that a higher total adverse childhood experiences severity score was associated with significantly increased risk for an earlier age of onset of psychiatric diagnoses in males. A similar model that evaluated the interaction of diagnosis revealed an earlier age of onset in obsessive–compulsive disorder and substance dependence, but not in schizophrenia and bipolar disorder. Conclusion: Our study indicates that adverse childhood experiences were associated with an earlier onset of major psychiatric conditions in men and individuals diagnosed with obsessive–compulsive disorder and substance dependence. Ongoing longitudinal assessments in first-degree relatives from these families are expected to identify mechanisms underlying this relationship.

scholarly journals Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder

2009 ◽  
Vol 31 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Quirino Cordeiro ◽  
Carolina Cappi ◽  
Aline Santos Sampaio ◽  
Selma Aliotti Palácios ◽  
Carlos Alberto de Bragança Pereira ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Molecular Genetic ◽  
Immunological Response ◽  
Obsessive Compulsive ◽  
Brazilian Sample ◽  
Compulsive Disorder ◽  
Objective Evidence ◽  
Gene Enhancer ◽  
Negative Findings ◽  
And Gender

OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (χ2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.

Initial Data on Recollections of Pathways to Inflated Responsibility Beliefs in Patients with Obsessive-Compulsive Disorder

2014 ◽  
Vol 43 (4) ◽  
pp. 385-395 ◽  
Author(s):  
Meredith E. Coles ◽  
Casey A. Schofield ◽  
Jacob A. Nota
Keyword(s):  
Initial Data ◽  
Obsessive Compulsive Disorder ◽  
Self Report ◽  
Published Data ◽  
Obsessive Compulsive ◽  
Childhood Experiences ◽  
Childhood Exposure ◽  
Compulsive Disorder ◽  
Inflated Responsibility ◽  
Maladaptive Beliefs

Background: Despite literature establishing a relationship between maladaptive beliefs and symptoms of obsessive-compulsive disorder (OCD), there are few studies addressing how these beliefs develop. Salkovskis and colleagues (1999) proposed specific domains of childhood experiences leading to heightened beliefs regarding responsibility. Prior studies in students and individuals who just completed treatment for OCD have found support for this theory. However, we are not aware of published data from individuals with current OCD. Aims: This paper presents initial data from adults currently meeting criteria for OCD as well as both anxious and non-anxious controls. Method: Recollections of childhood experiences, current OCD-related beliefs, and OCD symptoms were assessed using self-report measures in 39 individuals seeking treatment for OCD, 36 anxious controls and 39 healthy controls. Results: Initial data suggested that in individuals with OCD, increased reports of childhood exposure to overprotection and experiences where one's actions caused or influenced misfortune were associated with stronger OCD-related beliefs. Further, compared to community controls, individuals with OCD reported more childhood experiences where one's actions caused or influenced misfortune, though they did not differ from anxious controls in childhood responsibility experiences. Conclusions: These initial findings provide minimal support for the proposed model of the development of inflated responsibility beliefs, and highlight the need for research examining the etiology of OCD related beliefs with updated models, larger samples, and ultimately using prospective methods.

scholarly journals The Association of Trait Mindfulness and Self-compassion with Obsessive-Compulsive Disorder Symptoms: Results from a Large Survey with Treatment-Seeking Adults

2019 ◽  
Vol 44 (1) ◽  
pp. 120-135 ◽  
Author(s):  
Tamara Leeuwerik ◽  
Kate Cavanagh ◽  
Clara Strauss
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Distress Tolerance ◽  
Treatment Seeking ◽  
Trait Mindfulness ◽  
Obsessive Beliefs ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Self Compassion ◽  
Clinically Significant ◽  
Anxiety Depression

Abstract Little is known about the role of mindfulness and self-compassion in obsessive-compulsive disorder. This cross-sectional study examined associations of mindfulness and self-compassion with obsessive-compulsive disorder symptoms and with the obsessive beliefs and low distress tolerance thought to maintain them. Samples of treatment-seeking adults (N = 1871) and non-treatment-seeking adults (N = 540) completed mindfulness, self-compassion, obsessive-compulsive disorder, anxiety, depression, obsessive beliefs and distress tolerance questionnaires. Participants with clinically significant obsessive-compulsive disorder symptoms reported lower trait mindfulness and self-compassion compared to participants with clinically significant anxiety/depression and to non-clinical controls. Among the clinical sample, there were medium-large associations between mindfulness and self-compassion and obsessive-compulsive disorder symptoms, obsessive beliefs and distress tolerance. Mindfulness and self-compassion were unique predictors of obsessive-compulsive disorder symptoms, controlling for depression severity. Once effects of obsessive beliefs and distress tolerance were controlled, a small effect remained for mindfulness (facets) on obsessing symptoms and for self-compassion on washing and checking symptoms. Directions for future research and clinical implications are considered in conclusion.

Brain 5-HT function in obsessive-compulsive disorder

1997 ◽  
Vol 171 (3) ◽  
pp. 280-282 ◽  
Author(s):  
N. A. Fineberg ◽  
A. Roberts ◽  
S. A. Montgomery ◽  
P. J. Cowen
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Age And Gender ◽  
Compulsive Disorder ◽  
Therapeutic Advantage ◽  
Neuroendocrine Function ◽  
Prolactin Response ◽  
And Gender ◽  
Drug Free

BackgroundDrugs that potentiate brain serotonin (5-HT) neurotransmission are effective in the treatment of obsessive–compulsive disorder (OCD), but it is unclear whether disturbances in brain 5-HT function play a role in the pathophysiology of OCD.MethodWe studied the prolactin response to the selective 5-HT releasing agent d-fenfluramine in 14 non-depressed, drug-free OCD patients, and 14 healthy controls matched for age and gender.ResultsThe prolactin response to d-fenfluramine was significantly increased in OCD patients compared with controls.ConclusionsThe disparate results of studies of 5-HT neuroendocrine function in OCD make it unlikely that disturbances of brain 5-HT function play a central role in the pathophysiology of OCD. Increased brain 5-HT neurotransmission in non-depressed OCD subjects may represent an adaptive neurobehavioural mechanism which can be amplified to therapeutic advantage by treatment with 5-HT potentiating drugs.

Risk factors for delaying treatment seeking in obsessive-compulsive disorder

2010 ◽  
Vol 51 (5) ◽  
pp. 480-485 ◽  
Author(s):  
Mehmet Murat Demet ◽  
Artuner Deveci ◽  
E. Oryal Taşkın ◽  
Pınar Erbay Dündar ◽  
Aylin Türel Ermertcan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obsessive Compulsive Disorder ◽  
Treatment Seeking ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
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