Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide–membrane interactions of three related antimicrobial peptides

2016 ◽  
Vol 141 ◽  
pp. 528-536 ◽  
Author(s):  
Axel Hollmann ◽  
Melina Martínez ◽  
Martín E. Noguera ◽  
Marcelo T. Augusto ◽  
Anibal Disalvo ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Membrane Interactions

scholarly journals Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control

2016 ◽  
Vol 291 (25) ◽  
pp. 13301-13317 ◽  
Author(s):  
Aritreyee Datta ◽  
Dipita Bhattacharyya ◽  
Shalini Singh ◽  
Anirban Ghosh ◽  
Artur Schmidtchen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Disease Control ◽  
Plant Disease ◽  
Aromatic Amino Acids ◽  
Membrane Interactions ◽  
Plant Disease Control

The role of natural antimicrobial peptides during infection and chronic inflammation

2017 ◽  
Vol 111 (1) ◽  
pp. 5-26 ◽  
Author(s):  
Xiaojing Xia ◽  
Likun Cheng ◽  
Shouping Zhang ◽  
Lei Wang ◽  
Jianhe Hu
Keyword(s):  
Antimicrobial Peptides ◽  
Chronic Inflammation ◽  
Natural Antimicrobial

scholarly journals Membrane interactions and antimicrobial effects of layered double hydroxide nanoparticles

2017 ◽  
Vol 19 (35) ◽  
pp. 23832-23842 ◽  
Author(s):  
S. Malekkhaiat Häffner ◽  
L. Nyström ◽  
R. Nordström ◽  
Z. P. Xu ◽  
M. Davoudi ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Layered Double Hydroxide ◽  
Antimicrobial Agents ◽  
Inorganic Nanoparticles ◽  
Membrane Interactions ◽  
Antimicrobial Effects ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Membrane interactions are critical for the successful use of inorganic nanoparticles as antimicrobial agents and as carriers of, or co-actives with, antimicrobial peptides (AMPs).

scholarly journals Antibacterial Peptides Resistance in Staphylococcus aureus: Various Mechanisms and the Association with Pathogenicity

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1527
Author(s):  
Miki Kawada-Matsuo ◽  
Mi Nguyen-Tra Le ◽  
Hitoshi Komatsuzawa
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Peptides ◽  
Antibacterial Peptides ◽  
Low Concentrations ◽  
Component Systems ◽  
Two Component Systems ◽  
Resistant Strains ◽  
Resistant Mutants ◽  
High Concentrations

Staphylococcus aureus is a bacterium that mainly colonizes the nasal cavity and skin. To colonize the host, it is necessary for S. aureus to resist many antibacterial factors derived from human and commensal bacteria. Among them are the bacteria-derived antimicrobial peptides (AMPs) called bacteriocins. It was reported that some two-component systems (TCSs), which are signal transduction systems specific to bacteria, are involved in the resistance to several bacteriocins in S. aureus. However, the TCS-mediated resistance is limited to relatively low concentrations of bacteriocins, while high concentrations of bacteriocins still exhibit antibacterial activity against S. aureus. To determine whether we could obtain highly bacteriocin-resistant mutants, we tried to isolate highly nisin A-resistant mutants by exposing the cells to sub-minimum inhibitory concentrations (MICs) of nisin A. Nisin A is one of the bacteriocins produced by Lactococcus lactis and is utilized as a food preservative worldwide. Finally, we obtained highly nisin A-resistant mutants with mutations in one TCS, BraRS, and in PmtR, which is involved in the expression of pmtABCD. Notably, some highly resistant strains also showed increased pathogenicity. Based on our findings, this review provides up-to-date information on the role of TCSs in the susceptibility to antibacterial peptides. Additionally, the mechanism for high antimicrobial peptides resistance and its association with pathogenicity in S. aureus is elucidated.

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