scholarly journals The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy

2016 ◽  
Vol 9 (3) ◽  
pp. 53 ◽  
Author(s):  
I-Ni Hsieh ◽  
Kevan Hartshorn
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Antimicrobial Peptides ◽  
Influenza Virus Infection ◽  
Immunomodulatory Therapy

scholarly journals Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients

PLoS ONE ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. e13099 ◽  
Author(s):  
Vidya A. Arankalle ◽  
Kavita S. Lole ◽  
Ravi P. Arya ◽  
Anuradha S. Tripathy ◽  
Ashwini Y. Ramdasi ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza Virus ◽  
Viral Load ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Host Immune Response ◽  
Pandemic H1n1 ◽  
Differential Outcome ◽  
Pandemic H1n1 2009

Role of oxidants in influenza virus-induced gene expression

1998 ◽  
Vol 274 (1) ◽  
pp. L134-L142 ◽  
Author(s):  
Katharine Knobil ◽  
Augustine M. K. Choi ◽  
Gordon W. Weigand ◽  
David B. Jacoby
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Influenza Virus ◽  
Virus Infection ◽  
A549 Cells ◽  
Influenza Virus Infection ◽  
Pyrrolidine Dithiocarbamate ◽  
Oxygen Intermediates ◽  
Mrna Induction

Influenza virus-induced epithelial damage may be mediated, in part, by reactive oxygen intermediates (ROIs). In this study, we investigated the role of ROIs in the influenza virus-induced gene expression of antioxidant enzymes and in the activation of nuclear factor-κB (NF-κB), an oxidant-sensitive transcriptional factor. Influenza virus infection increased production of intracellular ROIs in A549 pulmonary epithelial cells. Induction of manganese superoxide dismutase (MnSOD) mRNA correlated with increased MnSOD protein and enzyme activity. Influenza virus infection also activated NF-κB binding as determined by an electrophoretic mobility shift assay. Pretreatment of A549 cells with N-acetyl-l-cysteine attenuated virus-induced NF-κB activation and interleukin (IL)-8 mRNA induction but did not block induction of MnSOD mRNA. In contrast, pyrrolidine dithiocarbamate blocked activation of NF-κB and induction of MnSOD and IL-8 mRNAs. Treatment with pyrrolidine dithiocarbamate also markedly decreased virus-induced cell death. Thus oxidants are involved in influenza virus-induced activation of NF-κB, in the expression of IL-8 and MnSOD, and in virus-induced cell death.

scholarly journals Role of Extracellular Vesicles in Influenza Virus Infection

2020 ◽  
Vol 10 ◽  
Author(s):  
Yuan Jiang ◽  
Xiaowen Cai ◽  
Jiwen Yao ◽  
Huanhuan Guo ◽  
Liangjun Yin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Extracellular Vesicles ◽  
Influenza Virus Infection

Progranulin aggravates pulmonary immunopathology during influenza virus infection

Thorax ◽  
2018 ◽  
Vol 74 (3) ◽  
pp. 305-308 ◽  
Author(s):  
Qin Luo ◽  
Xingxing Yan ◽  
Hongmei Tu ◽  
Yibing Yin ◽  
Ju Cao
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Inflammatory Diseases ◽  
Influenza Virus Infection ◽  
Epithelial Barrier ◽  
Alveolar Epithelial ◽  
Cytokines And Chemokines ◽  
Deficient Mice ◽  
Experimental Influenza

Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar–epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection.

scholarly journals Dissecting the Role of COPI Complexes in Influenza Virus Infection

2012 ◽  
Vol 87 (5) ◽  
pp. 2673-2685 ◽  
Author(s):  
E. Sun ◽  
J. He ◽  
X. Zhuang
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection

The role of oxidative stress in influenza virus infection

2017 ◽  
Vol 19 (12) ◽  
pp. 580-586 ◽  
Author(s):  
Miaomiao Liu ◽  
Fangzhao Chen ◽  
Teng Liu ◽  
Feimin Chen ◽  
Shuwen Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection
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