scholarly journals An Afferent Vagal Nerve Pathway Links Hepatic PPARα Activation to Glucocorticoid-Induced Insulin Resistance and Hypertension

2007 ◽  
Vol 5 (2) ◽  
pp. 91-102 ◽  
Author(s):  
Carlos Bernal-Mizrachi ◽  
Liu Xiaozhong ◽  
Li Yin ◽  
Russell H. Knutsen ◽  
Michael J. Howard ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vagal Nerve ◽  
Afferent Vagal

Assessment of the afferent vagal nerve in patients with gastroesophageal reflux

2002 ◽  
Vol 16 (7) ◽  
pp. 1042-1045 ◽  
Author(s):  
D. Hong ◽  
M. Kamath ◽  
S. Wang ◽  
J. Tabet ◽  
G. Tougas ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Vagal Nerve ◽  
Afferent Vagal

scholarly journals Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

2018 ◽  
Author(s):  
Caroline. E. Geisler ◽  
Susma. Ghimire ◽  
Chelsea. Hepler ◽  
Kendra E. Miller ◽  
Mark. R. Higgins ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Accumulation ◽  
Serum Insulin ◽  
Gaba Release ◽  
Type Ii Diabetes Mellitus ◽  
Vagal Nerve ◽  
Nucleotide Polymorphisms ◽  
Hepatic Expression ◽  
Hepatic Lipid Accumulation ◽  
Gaba Transporters

AbstractThe degree of hepatic lipid accumulation in obesity correlates with the severity of hyperinsulinemia and systemic insulin resistance. Here, we propose a mechanism that explains this associative link, whereby, hepatic steatosis dysregulates glucose and insulin homeostasis. Obesity-induced hepatocellular lipid accumulation results in hepatocyte depolarization. We have established that hepatocyte depolarization depresses hepatic afferent vagal nerve firing, increases GABA release from liver slices, and causes hyperinsulinemia. Preventing hepatic GABA release or eliminating the ability of the liver to communicate to the hepatic vagal nerve ameliorates the hyperinsulinemia and insulin resistance associated with diet-induced obesity. In people with obesity hepatic expression of GABA transporters is associated with glucose infusion and disposal rates during a hyperinsulinemic euglycemic clamp. Single nucleotide polymorphisms in hepatic GABA re-uptake transporters are associated with an increased incidence of type II diabetes mellitus. Herein, we identify GABA as a novel hepatokine that is dysregulated in obesity and whose release can be manipulated to mute or exacerbate the glucoregulatory dysfunction common to obesity.

scholarly journals GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222653 ◽  
Author(s):  
Hikaru Ueno ◽  
Ryo Ito ◽  
Shin-ichi Abe ◽  
Hitomi Ogino ◽  
Minoru Maruyama ◽  
...  
Keyword(s):  
Weight Loss ◽  
Vagal Nerve ◽  
Feeding Suppression ◽  
Afferent Vagal

Influence of Clonidine on Antihypertensive Selective Afferent Vagal Nerve Stimulation in Rats

2016 ◽  
Vol 19 (6) ◽  
pp. 597-606 ◽  
Author(s):  
Mortimer Gierthmuehlen ◽  
Debora Aguirre ◽  
Oscar Cota ◽  
Josef Zentner ◽  
Thomas Stieglitz ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Afferent Vagal

scholarly journals Effect of 5-HT4 receptor agonist on abdominal afferent vagal nerve activity in rats.

1996 ◽  
Vol 71 ◽  
pp. 245
Author(s):  
Hiroyuki Tamakai ◽  
Jun Sugawara ◽  
Takashi Ogawa ◽  
Masaru Minami ◽  
Mitsuhiro Yoshioka ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Vagal Nerve ◽  
Nerve Activity ◽  
Vagal Nerve Activity ◽  
Afferent Vagal

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 ◽  
Vol 123 (4) ◽  
pp. 1120-1128 ◽  
Author(s):  
Yukari Date ◽  
Noboru Murakami ◽  
Koji Toshinai ◽  
Shigeru Matsukura ◽  
Akira Niijima ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Vagal Nerve ◽  
Afferent Vagal

scholarly journals Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

2014 ◽  
Vol 2 (9) ◽  
pp. e12136 ◽  
Author(s):  
Keita Saku ◽  
Takuya Kishi ◽  
Kazuo Sakamoto ◽  
Kazuya Hosokawa ◽  
Takafumi Sakamoto ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Nerve Activity ◽  
Afferent Vagal

scholarly journals Afferent Vagal Nerve Stimulation Resets the Baroreflex Neural Arc and Inhibits Sympathetic Nerve Activity

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Keita Saku ◽  
Kazuo Sakamoto ◽  
Kazuya Hosokawa ◽  
Takamori Kakino ◽  
Masataka Ikeda ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Nerve Activity ◽  
Afferent Vagal
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