The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 ◽  
Vol 123 (4) ◽  
pp. 1120-1128 ◽  
Author(s):  
Yukari Date ◽  
Noboru Murakami ◽  
Koji Toshinai ◽  
Shigeru Matsukura ◽  
Akira Niijima ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Vagal Nerve ◽  
Afferent Vagal

scholarly journals Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects

2004 ◽  
pp. 447-450 ◽  
Author(s):  
R Takeno ◽  
Y Okimura ◽  
G Iguchi ◽  
M Kishimoto ◽  
T Kudo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Direct Action ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Subjects ◽  
Vagal Nerve ◽  
Gh Secretion ◽  
Afferent Vagal ◽  
Vagal Afferent ◽  
Plasma Gh

OBJECTIVE: Ghrelin is a potent peptide stimulating GH secretion. Besides its direct action on the pituitary, ghrelin has been reported to stimulate GH release via the vagal afferent nerve in rats. To examine the involvement of vagal nerve in ghrelin-induced GH secretion in humans, GH responses to ghrelin were compared between vagotomized patients with gastrectomy and normal subjects. METHODS: Ghrelin (0.2 microg/kg) or GHRH (1 microg/kg) was administered intravenously in vagotomized patients and normal subjects on separate days, and plasma GH responses to the stimuli were examined. RESULTS: Ghrelin caused a significant plasma GH rise in both vagotomized patients and normal subjects. Peak GH levels in vagotomized patients (37.5+/-16.9 ng/ml) were not different from those in normal subjects (29.9+/-23.1 ng/ml). The areas under the curve of GH response to ghrelin did not differ between the two groups. GHRH also increased GH levels, and peak GH levels and areas under the curve after GHRH stimulation were also comparable between vagotomized patients and normal subjects. CONCLUSIONS: In the present study, the involvement of the afferent vagal nerve in ghrelin-induced GH secretion was not confirmed in humans.

Role of Excitatory Amino Acids in the Control of Growth Hormone Secretion

Endocrine ◽  
2005 ◽  
Vol 28 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Enrique Aguilar ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Excitatory Amino Acids ◽  
Hormone Secretion ◽  
Growth Hormone Secretion

The Role of Zinc Dynamics in Growth Hormone Secretion

2013 ◽  
Vol 80 (6) ◽  
pp. 381-389 ◽  
Author(s):  
Maria Consolata Miletta ◽  
Martin H. Schöni ◽  
Kristin Kernland ◽  
Primus E. Mullis ◽  
Vibor Petkovic
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion

Role of obestatin on growth hormone secretion: An in vitro approach

2009 ◽  
Vol 390 (4) ◽  
pp. 1377-1381 ◽  
Author(s):  
Yolanda Pazos ◽  
Carlos J.P. Álvarez ◽  
Jesús P. Camiña ◽  
Omar Al-Massadi ◽  
Luísa M. Seoane ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion

Effect of actively immunizing sheep against growth hormone-releasing hormone or somatostatin on spontaneous pulsatile and neostigmine-induced growth hormone secretion

1995 ◽  
Vol 144 (1) ◽  
pp. 83-90 ◽  
Author(s):  
E Magnan ◽  
L Mazzocchi ◽  
M Cataldi ◽  
V Guillaume ◽  
A Dutour ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Physiological Role ◽  
Gh Secretion ◽  
Igf I ◽  
Plasma Gh ◽  
Hypophysial Portal

Abstract The physiological role of endogenous circulating GHreleasing hormone (GHRH) and somatostatin (SRIH) on spontaneous pulsatile and neostigmine-induced secretion of GH was investigated in adult rams actively immunized against each neuropeptide. All animals developed antibodies at concentrations sufficient for immunoneutralization of GHRH and SRIH levels in hypophysial portal blood. In the anti GHRH group, plasma GH levels were very low; the amplitude of GH pulses was strikingly reduced, although their number was unchanged. No stimulation of GH release was observed after neostigmine administration. The reduction of GH secretion was associated with a decreased body weight and a significant reduction in plasma IGF-I concentration. In the antiSRIH group, no changes in basal and pulsatile GH secretion or the GH response to neostigmine were observed as compared to controls. Body weight was not significantly altered and plasma IGF-I levels were reduced in these animals. These results suggest that in sheep, circulating SRIH (in the systemic and hypophysial portal vasculature) does not play a significant role in pulsatile and neostigmine-induced secretion of GH. The mechanisms of its influence on body weight and production of IGF-I remain to be determined. Journal of Endocrinology (1995) 144, 83–90

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