Association between vitamin D deficiency and adverse outcomes in critically ill adult patients

2017 ◽  
Vol 36 (6) ◽  
pp. 1733-1734 ◽  
Author(s):  
Simiao Tian ◽  
Huimin Dong
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Adverse Outcomes ◽  
Adult Patients

scholarly journals Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies

Critical Care ◽  
2014 ◽  
Vol 18 (6) ◽  
Author(s):  
Yan-Peng Zhang ◽  
You-Dong Wan ◽  
Tong-Wen Sun ◽  
Quan-Cheng Kan ◽  
Le-Xin Wang
Keyword(s):  
Vitamin D ◽  
Cohort Studies ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Meta Analysis ◽  
Adult Patients

scholarly journals Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1339
Author(s):  
Moustapha Dramé ◽  
Cécilia Cofais ◽  
Maxime Hentzien ◽  
Emeline Proye ◽  
Pécory Souleymane Coulibaly ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Outcomes ◽  
Oxygen Therapy ◽  
Invasive Mechanical Ventilation ◽  
Adverse Outcomes ◽  
Aged Patients ◽  
Aged People ◽  
Severity Of The Disease

Background: Vitamin D has diverse and extensive effects on the immune system, including activating innate immunity and reducing the overactive adaptive immune response. A systematic review was performed to identify and synthesize the best available evidence on the association between vitamin D level and risk of COVID-19, adverse outcomes and possible benefits of supplementation in aged 60 years or over. Methods: A literature search was performed in PubMed© and Scopus© for all publications from inception published before 15 March 2021. Studies reporting data from aged patients on vitamin D use and COVID-19 were included. Basic science articles, editorials and correspondence were excluded. Publication year, study design and setting, characteristics of the study population were extracted. This study is registered with PROSPERO, under the number CRD42020223993. Results: In total, 707 studies were identified, of which 11 observational studies were included in the final review. Four studies compared vitamin D-supplemented COVID-19 patients to non-supplemented patients, and seven compared patients with vitamin D deficiency to patients without deficiency. In all four studies, patients with vitamin D supplementation had better rates of primary clinical outcomes (death, the severity of the disease, oxygen therapy requirement…). In studies comparing patients with vitamin D deficiency and patients without vitamin D deficiency, those without vitamin D deficiency had better primary clinical outcomes (death rate, the severity of the disease, oxygen therapy requirement, invasive mechanical ventilation need…). Conclusion: This systematic review seems to support an association between vitamin D deficiency and the risk of COVID-19 in aged people. In addition, vitamin D deficiency appears to expose these subjects to a greater risk of adverse outcomes. Because of its simplicity of administration, and the rarity of side effects, including vitamin D in preventive strategies for certain viral diseases, it appears to be an attractive option.

Vitamin D deficiency in adult patients with ulcerative colitis: Prevalence and relationship with disease severity, extent, and duration

2019 ◽  
Vol 38 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Arjun Datt Law ◽  
Usha Dutta ◽  
Rakesh Kochhar ◽  
Chetana Vaishnavi ◽  
Shiva Kumar ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Adult Patients

scholarly journals A21 VITAMIN D DEFICIENCY AND ITS ASSOCIATION WITH CLINICAL OUTCOMES IN PRIMARY SCLEROSING CHOLANGITIS

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 24-26
Author(s):  
S Wang ◽  
A J Montano-Loza ◽  
M Ebadi
Keyword(s):  
Vitamin D ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Vitamin D Deficiency ◽  
Sclerosing Cholangitis ◽  
Adverse Outcomes ◽  
Vitamin D Status ◽  
Event Free Survival ◽  
Free Survival ◽  
University Of Alberta

Abstract Background Primary sclerosing cholangitis (PSC) is a progressive cholestatic disease involving chronic inflammation and fibrosis of intra- and extra-hepatic ducts. Vitamin D is a secosteroid implicated in anti-inflammatory and anti-fibrotic pathways, and its deficiency has been associated with worse outcomes in chronic liver disease. Vitamin D status may also influence the course of PSC but studies evaluating this link are scarce. Aims To determine the association of vitamin D deficiency with the development of cirrhosis, mortality, and need for liver transplantation in patients with PSC. Methods Ninety-four patients with the diagnosis of PSC were evaluated and followed by the autoimmune liver disease clinic at the University of Alberta, Edmonton, Canada. Clinical data were recovered from medical charts. Vitamin D status was defined by the serum concentration of 25-hydroxyvitamin D3. Patients with levels <50 nmol/L (10 ng/ml) were defined as deficient. Univariate and multivariate analyses were constructed using the Cox proportional hazards regression models. Event-free survival was defined as time from vitamin D assessment to the time of liver transplant or death. Results Mean age at PSC diagnosis was 32±14 years, with 67% of patients being male. The mean vitamin D level was 69±33 nmol/L (range, 4–163 nmol/L) and 26 patients (28%) had vitamin D deficiency (<50 nmol/L). Among 85 patients without cirrhosis at diagnosis, 43 patients (51%) developed cirrhosis. By univariate Cox analysis, serum ALP, albumin, bilirubin and vitamin D deficiency were predictors of cirrhosis development. Vitamin D deficiency was independently associated with higher risk of developing cirrhosis (HR 2.11, 95% CI 1.002–4.44, P=0.049) after adjusting for other predictors. Median time to develop cirrhosis was shorter in patients with vitamin D deficiency (6.8 years; 95% CI, 1.7–11.8) compared to those without (10.8 years; 95% CI, 9.2 -12.4; P=0.007). Over a median follow-up period of 5.6 years, adverse outcomes (liver transplant or death) were observed in 34 patients (36%). Serum levels of albumin, ALP, bilirubin, INR, platelet count, ascites, variceal bleeding and vitamin D deficiency were associated with adverse outcomes in univariate analysis. Vitamin D deficiency was independently associated with higher risk of adverse endpoints (HR 2.87, 95% CI, 1.16–7.12, P=0.02) after adjusting for confounding factors. Event-free survival was shorter in the patients with vitamin D deficiency compared to those without deficiency (7.1 years; 95% CI, 2.4–11.9 vs. 11.4 years; 95% CI, 8.9–13.9, P=0.03, Figure 1). Conclusions Vitamin D deficiency was frequent in patients with PSC and was associated with higher risk of progression to cirrhosis, as well as decreased time to death and liver transplantation. The possibility of improving outcomes in PSC by vitamin D supplementation awaits further investigation. Funding Agencies Food and Health Innovation Initiative (Vitamin Fund), University of Alberta

Relationship of Vitamin D Deficiency to Clinical Outcomes in Critically Ill Patients

2012 ◽  
Vol 36 (6) ◽  
pp. 713-720 ◽  
Author(s):  
David M. Higgins ◽  
Paul E. Wischmeyer ◽  
Kelly M. Queensland ◽  
Stefan H. Sillau ◽  
Alexandra J. Sufit ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Relationship Of

scholarly journals Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children

2018 ◽  
Vol 175 ◽  
pp. 164-169 ◽  
Author(s):  
Jessica A. Alvarez ◽  
Jocelyn R. Grunwell ◽  
Scott E. Gillespie ◽  
Vin Tangpricha ◽  
Kiran B. Hebbar
Keyword(s):  
Vitamin D ◽  
Redox Potential ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Children
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