Vitamin D deficiency relation to sepsis, paediatric risk of mortality III score, need for ventilation support, length of hospital stay, and duration of mechanical ventilation in critically ill children: A meta‐analysis

2020 ◽  
Author(s):  
Mingyi He ◽  
Tao Cao ◽  
Jing Wang ◽  
Changyuan Wang ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mechanical Ventilation ◽  
Hospital Stay ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Critically Ill Children ◽  
Risk Of Mortality ◽  
Ventilation Support

scholarly journals Efficacy of probiotics in the prevention of VAP in critically ill ICU patients: an updated systematic review and meta-analysis of randomized control trials

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Priyam Batra ◽  
Kapil Dev Soni ◽  
Purva Mathur
Keyword(s):  
Systematic Review ◽  
Mechanical Ventilation ◽  
Hospital Mortality ◽  
Hospital Stay ◽  
Critically Ill ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Mean Difference ◽  
Icu Stay ◽  
Length Of Icu Stay

Abstract Introduction Ventilator-associated pneumonia (VAP) is reported as the second most common nosocomial infection among critically ill patients with the incidence ranging from 2 to 16 episodes per 1000 ventilator days. The use of probiotics has been shown to have a promising effect in many RCTs. Our systematic review and meta-analysis were thus planned to determine the effect of probiotic use in critically ill ventilated adult patients on the incidence of VAP, length of hospital stay, length of ICU stay, duration of mechanical ventilation, the incidence of diarrhea, and the incidence of oropharyngeal colonization and in-hospital mortality. Methodology Systematic search of various databases (such as Embase, Cochrane, and Pubmed), published journals, clinical trials, and abstracts of the various major conferences were made to obtain the RCTs which compare probiotics with placebo for VAP prevention. The results were expressed as risk ratios or mean differences. Data synthesis was done using statistical software - Review Manager (RevMan) Version 5.4 (The Cochrane Collaboration, 2020). Results Nine studies met our inclusion criterion and were included in the meta-analysis. The incidence of VAP (risk ratio: 0.70, CI 0.56, 0.88; P = 0.002; I2 = 37%), duration of mechanical ventilation (mean difference −3.75, CI −6.93, −0.58; P 0.02; I2 = 96%), length of ICU stay (mean difference −4.20, CI −6.73, −1.66; P = 0.001; I2 = 84%) and in-hospital mortality (OR 0.73, CI 0.54, 0.98; P = 0.04; I2 = 0%) in the probiotic group was significantly lower than that in the control group. Probiotic administration was not associated with a statistically significant reduction in length of hospital stay (MD −1.94, CI −7.17, 3.28; P = 0.47; I2 = 88%), incidence of oro-pharyngeal colonization (OR 0.59, CI 0.33, 1.04; P = 0.07; I2 = 69%), and incidence of diarrhea (OR 0.59, CI 0.34, 1.03; P = 0.06; I2 = 38%). Discussion Our meta-analysis shows that probiotic administration has a promising role in lowering the incidence of VAP, the duration of mechanical ventilation, length of ICU stay, and in-hospital mortality.

scholarly journals Vitamin D deficiency in critically ill children: a systematic review and meta-analysis

Critical Care ◽  
2017 ◽  
Vol 21 (1) ◽  
Author(s):  
James Dayre McNally ◽  
Nassr Nama ◽  
Katie O’Hearn ◽  
Margaret Sampson ◽  
Karin Amrein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Meta Analysis ◽  
Critically Ill Children

scholarly journals A Prospective Observational Study of Hypomagnesemia in Critically Ill Paediatric Patients

2020 ◽  
Vol 40 (2) ◽  
pp. 67-71
Author(s):  
Channanayaka Chandrashekhar ◽  
Reshmi Pillai ◽  
Prajwala Hassan Vasudev ◽  
Tirin Babu ◽  
George Mathew Panachiyil
Keyword(s):  
Mechanical Ventilation ◽  
Hospital Stay ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Serum Magnesium ◽  
Length Of Hospital Stay ◽  
Inotropic Support ◽  
Respiratory Support ◽  
Common Finding ◽  
Critically Ill Children

Introduction: Magnesium deficiency, a common finding in critically ill patients, is associated with increased need for respiratory support, increased duration of ICU stay and mortality. The primary objective of our study is to assess the prevalence of hypomagnesaemia in critically ill children (requiring inotropic support, respiratory support, and fluid resuscitation) on admission in the Paediatric Intensive Care Unit (PICU). The secondary objective is to evaluate its relationship with the length of hospital stay and mortality. Methods: This prospective observational study was conducted in the PICU of a tertiary care hospital. In this study, serum magnesium levels at admission were measured along with other laboratory tests, after informed consent. Serum magnesium levels were assayed in our laboratory. The normal range of serum magnesium in our lab is 1.7-2.7 mg/dl. During admission in PICU, there was follow-up for ionotrope administration, need for mechanical ventilation, APACHE II score, PICU length of stay and mortality. Results: In this study, 350 critically ill children requiring hemodynamic / respiratory support were chosen. However, 83 children were excluded from study as they were discharged against medical advice. The prevalence of hypomagnesemia in this study was 43.4%. There was no significant association between hypomagnesemia, duration of hospital stay and mortality. Conclusion: Hypomagnesaemia is a common finding in critically ill paediatric patients, however there is no significant association noted in regards to length of hospital stay, duration of mechanical ventilation, inotropic support and mortality.

scholarly journals Does Route of Full Feeding Affect Outcome among Ventilated Critically Ill COVID-19 Patients: A Prospective Observational Study

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 153
Author(s):  
Dimitrios Karayiannis ◽  
Sotirios Kakavas ◽  
Aikaterini Sarri ◽  
Vassiliki Giannopoulou ◽  
Christina Liakopoulou ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Hospital Stay ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Length Of Hospital Stay ◽  
Feeding Practices ◽  
Duration Of Hospital Stay ◽  
Ventilation Support ◽  
Mechanical Ventilation Support ◽  
Duration Of Hospitalization

The outbreak of the new coronavirus strain SARS-CoV-2 (COVID-19) highlighted the need for appropriate feeding practices among critically ill patients admitted to the intensive care unit (ICU). This study aimed to describe feeding practices of intubated COVID-19 patients during their second week of hospitalization in the First Department of Critical Care Medicine, Evaggelismos General Hospital, and evaluate potential associations with all cause 30-day mortality, length of hospital stay, and duration of mechanical ventilation. We enrolled adult intubated COVID-19 patients admitted to the ICU between September 2020 and July 2021 and prospectively monitored until their hospital discharge. Of the 162 patients analyzed (52.8% men, 51.6% overweight/obese, mean age 63.2 ± 11.9 years), 27.2% of patients used parenteral nutrition, while the rest were fed enterally. By 30 days, 34.2% of the patients in the parenteral group had died compared to 32.7% of the patients in the enteral group (relative risk (RR) for the group receiving enteral nutrition = 0.97, 95% confidence interval = 0.88–1.06, p = 0.120). Those in the enteral group demonstrated a lower duration of hospital stay (RR = 0.91, 95% CI = 0.85-0.97, p = 0.036) as well as mechanical ventilation support (RR = 0.94, 95% CI = 0.89–0.99, p = 0.043). Enteral feeding during second week of ICU hospitalization may be associated with a shorter duration of hospitalization and stay in mechanical ventilation support among critically ill intubated patients with COVID-19.

scholarly journals Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children

2018 ◽  
Vol 175 ◽  
pp. 164-169 ◽  
Author(s):  
Jessica A. Alvarez ◽  
Jocelyn R. Grunwell ◽  
Scott E. Gillespie ◽  
Vin Tangpricha ◽  
Kiran B. Hebbar
Keyword(s):  
Vitamin D ◽  
Redox Potential ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Children

scholarly journals Vitamin D deficiency in critically ill children

2020 ◽  
Vol 3 (2) ◽  
pp. 20-25
Author(s):  
Eman Abo EL Magd M. Ibrahim ◽  
Ahmed El-Abd Ahmad ◽  
Mohammed H. Hassan ◽  
Nagwan I. Rashwan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Children
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