Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)

2019 ◽  
Vol 19 (10) ◽  
pp. e351
Author(s):  
Juan José Garcés ◽  
Gabriel Bretones ◽  
Leire Burgos ◽  
Rafael Valdés-Mas ◽  
Diego Alignani ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Genetic Characterization ◽  
Non Invasive

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma

Leukemia ◽  
2020 ◽  
Vol 34 (11) ◽  
pp. 3007-3018
Author(s):  
Juan-José Garcés ◽  
◽  
Gabriel Bretones ◽  
Leire Burgos ◽  
Rafael Valdes-Mas ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Genetic Characterization ◽  
Non Invasive

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Blood ◽  
2013 ◽  
Vol 122 (22) ◽  
pp. 3591-3598 ◽  
Author(s):  
Bruno Paiva ◽  
Teresa Paino ◽  
Jose-Maria Sayagues ◽  
Mercedes Garayoa ◽  
Laura San-Segundo ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Circadian Rhythms ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Distribution Profile ◽  
Detailed Characterization ◽  
Key Points ◽  
Circadian Distribution

Key Points Detailed characterization of myeloma circulating tumor cells shows that these represent a unique subpopulation of BM clonal PCs. Myeloma CTCs are clonogenic, quiescent, and may represent an ancestral clone potentially driven by circadian rhythms.

scholarly journals Genomic Instability in Circulating Tumor Cells

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3001
Author(s):  
Monique Oliveira Freitas ◽  
John Gartner ◽  
Aline Rangel-Pozzo ◽  
Sabine Mai
Keyword(s):  
Tumor Cells ◽  
Genomic Instability ◽  
Circulating Tumor Cells ◽  
Genetic Characterization ◽  
Chromosome Instability ◽  
Distant Metastases ◽  
Cancer Subtypes ◽  
Common Features ◽  
Tumor Cell Heterogeneity

Circulating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful tool for a better understanding of the molecular changes occurring at tumor initiation and during tumor progression/metastasis. In this review, we will highlight recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability in CTCs. We will focus on the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.

Abstract 5361: Isolation and genetic characterization of circulating tumor cells from cancer of unknown primary

2020 ◽  
Author(s):  
Elisa Porcellini ◽  
Francesco Gelsomino ◽  
Noemi Laprovitera ◽  
Mattia Riefolo ◽  
Marianna Garonzi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Genetic Characterization ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals Technical Insights into Highly Sensitive Isolation and Molecular Characterization of Fixed and Live Circulating Tumor Cells for Early Detection of Tumor Invasion

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169427 ◽  
Author(s):  
Sophie Laget ◽  
Lucile Broncy ◽  
Katia Hormigos ◽  
Dalia M. Dhingra ◽  
Fatima BenMohamed ◽  
...  
Keyword(s):  
Early Detection ◽  
Tumor Cells ◽  
Molecular Characterization ◽  
Circulating Tumor Cells ◽  
Tumor Invasion ◽  
Highly Sensitive

The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Sara Memarpour ◽  
Ghazaleh Khalili-Tanha ◽  
Awa Alizadeh Ghannad ◽  
Masoud Sharifian Razavi ◽  
Mona Joudi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Tumor Biology ◽  
Predictive Biomarkers ◽  
Invasive Approach ◽  
New Approach ◽  
Non Invasive ◽  
Gi Cancer ◽  
Gi Cancers ◽  
Tumor Dna

: Gastrointestinal (GI) cancer is one of the most common cancers globally. Genetic and epigenetic mechanisms are involved in its pathogenesis. The conventional methods for diagnosis and screening for GI cancers are often invasive and have other limitations. In the era of personalized medicine, a novel non-invasive approach called liquid biopsy has been introduced for the detection and management of GI cancers, which focuses on the analysis of circulating tumor cells (CTCs) and circulating cell-free tumor DNA (ctDNA). Several studies have shown that this new approach allows for an improved understanding of GI tumor biology and will lead to an improvement in clinical management. The aim of the current review is to explore the clinical applications of CTCs and ctDNA in patients with GI cancer.

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