Distinct cytokine profile in juvenile systemic lupus erythematosus-associated macrophage activation syndrome

2013 ◽  
Vol 146 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Masaki Shimizu ◽  
Tadafumi Yokoyama ◽  
Yuko Tokuhisa ◽  
Sayaka Ishikawa ◽  
Yasuhisa Sakakibara ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Cytokine Profile ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Activation Syndrome

scholarly journals Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Asaad Alkoht ◽  
Ibrahem Hanafi ◽  
Basheer Khalil
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Literature Review ◽  
Lupus Erythematosus ◽  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Adults And Children ◽  
Juvenile Sle ◽  
Activation Syndrome

Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it is extremely rare to be the initial presentation of jSLE. Here, we report two patients with juvenile SLE who initially presented with MAS. One of the two patients is 4 years old. This is the youngest reported patient to our knowledge.

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