scholarly journals Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty-eight patients

2009 ◽  
Vol 60 (11) ◽  
pp. 3388-3399 ◽  
Author(s):  
Alessandro Parodi ◽  
Sergio Davì ◽  
Alejandra Beatriz Pringe ◽  
Angela Pistorio ◽  
Nicolino Ruperto ◽  
...  
2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Asaad Alkoht ◽  
Ibrahem Hanafi ◽  
Basheer Khalil

Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it is extremely rare to be the initial presentation of jSLE. Here, we report two patients with juvenile SLE who initially presented with MAS. One of the two patients is 4 years old. This is the youngest reported patient to our knowledge.


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