OR.82. Mesenchymal Stem Cells Treat CNS Autoimmunity Through a Dual Effect On Inflammation and Tissue Damage

2006 ◽  
Vol 119 ◽  
pp. S35
Author(s):  
Enrico Pedemonte ◽  
Barbara Gallo ◽  
Ezio Gerdoni ◽  
Simona Casazza ◽  
Silvia Musio ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Damage ◽  
Dual Effect ◽  
Cns Autoimmunity

Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells

2021 ◽  
Author(s):  
Ruriko Sekiya-Aoyama ◽  
Yoshinori Arisaka ◽  
Masahiro Hakariya ◽  
Hiroki Masuda ◽  
Takanori Iwata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Functional Groups ◽  
Molecular Mobility ◽  
Adipocyte Differentiation ◽  
Negative Charge ◽  
Dual Effect ◽  
Independent Parameters

Mesenchymal stem cells on polyrotaxane surfaces underwent enhanced osteoblast and adipocyte differentiation. Two independent parameters, high molecular mobility and negative charge on the surfaces, may not offset the effect to promote both differentiation.

scholarly journals Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells

Stem Cells ◽  
2016 ◽  
Vol 34 (9) ◽  
pp. 2393-2406 ◽  
Author(s):  
Dongsheng Jiang ◽  
Jana Muschhammer ◽  
Yu Qi ◽  
Andrea Kügler ◽  
Juliane C. de Vries ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Damage

scholarly journals The Art of Mesenchymal Stem Cells in Liver Fibrosis Management

2021 ◽  
Vol 3 (2) ◽  
pp. 15-24
Author(s):  
Farid Amansyah ◽  
Dito Anurogo
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Tissue Damage ◽  
Fundamental Concept ◽  
Scientific Review ◽  
Safety And Efficacy ◽  
Experimental Animals

Liver fibrogenesisis chronic tissue damage characterized by an extracellular ac-cumulation of fibrillar matrix associated with continuous degradation and remod-elling. This scientific review describes current concepts on the pathophysiology of liver fibrosis, inflammation asa fundamental concept of liver fibrosis, mechanistic concepts of liver fibrosis, the role of mesenchymal stem cells (MSC) in liver injury, the functional effects of MSC secretome, the advantages of secretome ther-apy, and the latest research developments on MSC. The role of MSCs has been proven in many liver fibrosis studies involving experimental animals. However, it still requires further research for safety and efficacy aspects.

scholarly journals Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Haojiang Li ◽  
Shi Shen ◽  
Haitao Fu ◽  
Zhenyong Wang ◽  
Xu Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Tissue Regeneration ◽  
Tissue Damage ◽  
Material Selection ◽  
Immune Microenvironment ◽  
Chronic Injury ◽  
Research Fields

The inflammatory response to chronic injury affects tissue regeneration and has become an important factor influencing the prognosis of patients. In previous stem cell treatments, it was revealed that stem cells not only have the ability for direct differentiation or regeneration in chronic tissue damage but also have a regulatory effect on the immune microenvironment. Stem cells can regulate the immune microenvironment during tissue repair and provide a good “soil” for tissue regeneration. In the current study, the regulation of immune cells by mesenchymal stem cells (MSCs) in the local tissue microenvironment and the tissue damage repair mechanisms are revealed. The application of the concepts of “seed” and “soil” has opened up new research avenues for regenerative medicine. Tissue engineering (TE) technology has been used in multiple tissues and organs using its biomimetic and cellular cell abilities, and scaffolds are now seen as an important part of building seed cell microenvironments. The effect of tissue engineering techniques on stem cell immune regulation is related to the shape and structure of the scaffold, the preinflammatory microenvironment constructed by the implanted scaffold, and the material selection of the scaffold. In the application of scaffold, stem cell technology has important applications in cartilage, bone, heart, and liver and other research fields. In this review, we separately explore the mechanism of MSCs in different tissue and organs through immunoregulation for tissue regeneration and MSC combined with 3D scaffolds to promote MSC immunoregulation to repair damaged tissues.

scholarly journals Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis

2007 ◽  
Vol 56 (4) ◽  
pp. 1175-1186 ◽  
Author(s):  
Andrea Augello ◽  
Roberta Tasso ◽  
Simone Maria Negrini ◽  
Ranieri Cancedda ◽  
Giuseppina Pennesi
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Tissue Damage ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Collagen Induced Arthritis ◽  
Marrow Mesenchymal Stem Cells

Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells

2016 ◽  
Vol 193 ◽  
pp. 227-236 ◽  
Author(s):  
Byung-Kwan Seo ◽  
Hee-Kyoung Ryu ◽  
Yeon-Cheol Park ◽  
Jeong-Eun Huh ◽  
Yong-Hyeon Baek
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Bone Marrow Cells ◽  
Dual Effect ◽  
Marrow Cells

Study On Mechanism of Bone Marrow Mesenchymal Stem Cell in Treating Patients with Rheumatoid Arthritis.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4486-4486
Author(s):  
Zhenhua Qiao ◽  
Lihui Ma
Keyword(s):  
Rheumatoid Arthritis ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Tissue Damage ◽  
Conflicts Of Interest ◽  
Allogeneic Mscs ◽  
Colony Forming Unit ◽  
Marrow Mesenchymal Stem Cells

Abstract Abstract 4486 Objective To explore mechanism of Mesenchymal stem cells in treating Rheumatoid arthritis. Methods (1) MSCs were isolated from Bone marrow samples of Rheumatoid arthritis(RA)patients and purified by density gradient centrifagation and cultured in vitro. Morphology, immunophenotype, and proliferative property of bMSC and colony forming unit-fibroblast (CFU-F) were measured and analyzed. (2) In an in vitro co-culture system, MSCs were observed to modulate proliferation,activation, and maturation of T and B lymphocytes of Rheumatoid arthritis(RA)patients. The expression of IL-1?ATNF-a?ATGF-β were obviously changed.(3) Bone marrow- derived BMSCs of wistar rats were isolated and cultured in vitro routinely and the fourth passage as taken for identification of specific surface antigens by flowcytometry, then were labled with 5- BrdU in vitro. The model of collagen-induced arthritis (CIA) rats were established. 5- BrdU labled BMSCs were implanted through tail vein to model rats. At 4 weeks after BMSCs transplantation, immunohistochemical examinations were used to investigate BMSCs aggregate around the knee joints.and identify the contribution of bone marrow– derived cells to joints damage repair. Results (1) The culture expanded cells from RA patients presented a typical fibroblast-like morphology. Cells were positive for SH2(CD105),CD71,and CD44, but negative for CD45.Their proliferative capacity and CFU-F number were similar to those of bMSCs from healthy donors. (2) MSCs significantly inhibited T,B cell proliferation. MSCs also could down-regulating the levels of IL-1, TNF and up-regulating TGF-β. (3) Flow cytometry showed that BMSCs expressed CD44, CD71and CD105, but no CD45,CD34. At 4 weeks after the cells transplantation, the implanted cells were detected in the damaged joints of the model rats, which is not founded in normal knee joints of the rats'.and at same time there are more OPG(osteoprotegerin) positive. Conclusion (1) In the aspect of morphology, immuno -phenotypen, proliferative property and colony forming unit-fibroblast (CFU-F),MSCs from bone marrow of RA patients are not different from those of MSCs isolated from bone marrow of normal donors,MSCs from the bone marrow of RA patients have the potentiality in clinical application.(2) Human bone marrow MSCs inhibited Tcell and Bcell activation and proliferation in patients with RA in vitro. And these immuno –modulatory effects were not MHC-restricted. (3) bone marrow mesenchymal stem cells prevents tissue damage in arthritis. Allogeneic MSCs can engraft at sites of tissue damage,and prepair damage. That provided positive results for developing effective therapy for Rheumatoid arthritis. Disclosures: No relevant conflicts of interest to declare.

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity

2013 ◽  
Vol 30 ◽  
pp. 103-114 ◽  
Author(s):  
Natalie L. Payne ◽  
Guizhi Sun ◽  
Courtney McDonald ◽  
Leon Moussa ◽  
Ashley Emerson-Webber ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cns Autoimmunity
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