The Protective Effect of Olive Leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats

2016 ◽  
Vol 65 ◽  
pp. 611-626
Author(s):  
Nahed Mohamed Mansour Emam ◽  
Khadija Abdul Jalil Fadladdeen
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Tissue Damage ◽  
Skin Tissue ◽  
Olive Leaves ◽  
Marrow Mesenchymal Stem Cells ◽  
Gamma Irradiated

scholarly journals Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis

2007 ◽  
Vol 56 (4) ◽  
pp. 1175-1186 ◽  
Author(s):  
Andrea Augello ◽  
Roberta Tasso ◽  
Simone Maria Negrini ◽  
Ranieri Cancedda ◽  
Giuseppina Pennesi
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Tissue Damage ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Collagen Induced Arthritis ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis

2012 ◽  
Vol 8 (3) ◽  
pp. 357-367 ◽  
Author(s):  
Xiangjun Zeng ◽  
Shan Ping Yu ◽  
Tammi Taylor ◽  
Molly Ogle ◽  
Ling Wei
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

Protective effect of [Pyr1]-apelin-13 on oxidative stress-induced apoptosis in hair cell-like cells derived from bone marrow mesenchymal stem cells

2019 ◽  
Vol 853 ◽  
pp. 25-32 ◽  
Author(s):  
Somayeh Niknazar ◽  
Hojjat-Allah Abbaszadeh ◽  
Hassan Peyvandi ◽  
Omidvar Rezaei ◽  
Hosna Forooghirad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Hair Cell ◽  
Marrow Mesenchymal Stem Cells ◽  
Induced Apoptosis

scholarly journals Transplantation of Bone Marrow Mesenchymal Stem Cells Prevents Radiation-Induced Artery Injury by Suppressing Oxidative Stress and Inflammation

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Yanjun Shen ◽  
Xin Jiang ◽  
Lingbin Meng ◽  
Chengcheng Xia ◽  
Lihong Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Human Bone ◽  
Human Bone Marrow ◽  
High Dose ◽  
Marrow Mesenchymal Stem Cells ◽  
Radiation Induced

The present study aims to explore the protective effect of human bone marrow mesenchymal stem cells (hBMSCs) on radiation-induced aortic injury (RIAI). hBMSCs were isolated and cultured from human bone marrow. Male C57/BL mice were irradiated with a dose of 18-Gy 6MV X-ray and randomly treated with either vehicle or hBMSCs through tail vein injection with a dose of 103 or 104 cells/g of body weight (low or high dose of hBMSCs) within 24 h. Aortic inflammation, oxidative stress, and vascular remodeling were assessed by immunohistochemical staining at 3, 7, 14, 28, and 84 days after irradiation. The results revealed irradiation caused aortic cell apoptosis and fibrotic remodeling indicated by aortic thickening, collagen accumulation, and increased expression of profibrotic cytokines (CTGF and TGF-β). Further investigation showed that irradiation resulted in elevated expression of inflammation-related molecules (TNF-α and ICAM-1) and oxidative stress indicators (4-HNE and 3-NT). Both of the low and high doses of hBMSCs alleviated the above irradiation-induced pathological changes and elevated the antioxidant enzyme expression of HO-1 and catalase in the aorta. The high dose even showed a better protective effect. In conclusion, hBMSCs provide significant protection against RIAI possibly through inhibition of aortic oxidative stress and inflammation. Therefore, hBMSCs can be used as a potential therapy to treat RIAI.

The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression

2019 ◽  
Vol 215 (9) ◽  
pp. 152519 ◽  
Author(s):  
Zeinab Vahidinia ◽  
Abolfazl Azami Tameh ◽  
Majid Nejati ◽  
Cordian Beyer ◽  
Sayyed Alireza Talaei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Ischemic Stroke ◽  
Protective Effect ◽  
Rat Model ◽  
Marrow Mesenchymal Stem Cells ◽  
Kinase Expression
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