PROGNOSTIC VALUE OF PET MPI MYOCARDIAL FLOW RESERVE IN CABG PATIENTS

2021 ◽  
Vol 37 (10) ◽  
pp. S75
Author(s):  
I Soltani ◽  
R Chatta ◽  
B Potter ◽  
A Matteau ◽  
D Juneau ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Myocardial Flow Reserve ◽  
Flow Reserve ◽  
Cabg Patients ◽  
Myocardial Flow

Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Computed Tomography in Patients with Systemic Sclerosis

2021 ◽  
pp. jrheum.210040
Author(s):  
Attila Feher ◽  
Nabil E. Boutagy ◽  
Evangelos K. Oikonomou ◽  
Stephanie Thorn ◽  
Yi-Hwa Liu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systemic Sclerosis ◽  
Myocardial Flow Reserve ◽  
Coronary Microvascular Dysfunction ◽  
Emission Computed Tomography ◽  
Flow Reserve ◽  
Positron Emission ◽  
Pet Ct ◽  
Myocardial Flow ◽  
Healthy Participants

Objective To investigate the association between Raynaud phenomenon (RP) and coronary microvascular dysfunction, we measured myocardial flow reserve (MFR) using positron emission tomography/computed tomography (PET/CT) in primary and secondary RP patients and controls. Methods RP patients, patient controls and healthy participants who underwent dynamic reststress 82-Rubidium PET/CT were studied. Differences in heart rate-blood pressure product corrected MFR and clinical predictors of reduced MFR (< 2.0) were determined. Results 49 RP patients (80% female, 65 ± 11 years): 11 primary RP, 18 systemic sclerosis (SSc) and 20 other autoimmune diseases (AID) (n=6 systemic lupus erythematosus, n=6 rheumatoid arthritis, n=4 overlap syndrome, n=2 Sjogren's syndrome, n=2 inflammatory arthritis), 49 matched patients without RP or AID (78% female, 64 ± 13 years) and 14 healthy participants (50% female, 35 ± 5 years) were studied. Primary RP patients, matched patient controls and healthy participants had comparable MFR. SSc-RP patients had significantly reduced MFR (1.62 ± 0.32) compared to matched patient controls (p=0.03, 2.06 ± 0.61) and to healthy participants (p=0.01, 2.22 ± 0.44). In multivariable logistic regression, SSc was an independent predictor of reduced MFR. We identified a correlation between time since AID diagnosis and MFR (r= -0.37; 95% CI: -0.61 to -0.09; p=0.01). Conclusion Our findings suggest that only secondary, not primary, RP is associated with reduced MFR, and that SSc-RP patients have reduced MFR compared to primary RP and other

Coronary flow quantification estimated by dynamic 320-detector CT angiography: validation by 13N ammonia PET myocardial flow reserve

2021 ◽  
Author(s):  
Yuka Matsuo ◽  
Michinobu Nagao ◽  
Atsushi Yamamoto ◽  
Kiyoe Ando ◽  
Risako Nakao ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Coronary Flow ◽  
Clinical Work ◽  
Myocardial Flow Reserve ◽  
Flow Quantification ◽  
Flow Index ◽  
Characteristic Analysis ◽  
Flow Reserve ◽  
Dose Modulation ◽  
Myocardial Flow

Objectives: Resting coronary flow index (rCFI) estimated by 320-detector low-dose dynamic coronary CT angiography (CCTA) is a direct flow quantification using intracoronary attenuation. We propose modified-rCFI from new protocol combining dynamic scan and standard CCTA using dose-modulation, and validate its consistency with quantitative values and ischemia depicted by 13N-ammonia PET (NH3-PET). Methods: 46 patients who underwent dynamic CCTA and NH3-PET for coronary artery disease were evaluated using original rCFI in 21 patients and modified-rCFI in 25 patients. Two types of rCFI were calculated for three major coronary arteries. Myocardial blood flow (MBF) at rest and stress, myocardial flow reserve (MFR), and the presence or absence of ischemia for three major territories were depicted by NH3-PET. Coronary territories were categorized as territories with MFR <2.0, ≥2.0, or with and without ischemia. Receiver operating characteristic analysis was performed to determine the optimal cut-off of rCFI to distinguish territories with MFR <2.0 or the presence of ischemia. Results: rCFI and modified-rCFI had significant positive correlations with stress MBF and MFR. The optical cut-offs of rCFI and modified-rCFI of 0.39 and 0.61 could detect territories with MFR <2.0, with AUCs of 0.75 and 0.73, sensitivities of 48 and 34%, and specificities of 97 and 98%. Optimal cut-offs of rCFI and modified-rCFI distinguished ischemic segments from non-ischemic segments, with AUCs of 0.75 and 0.91, sensitivities of 53 and 50%, and specificities of 93 and 95%. Conclusion: Two types of rCFI correlated with quantitative values from NH3-PET, and were consistent with a high specificity in detecting functional ischemia. Advances in knowledge: rCFI can contribute as additional functional test over standard CCTA in clinical work-up.

scholarly journals Cardiac Autonomic Function Is Associated With Myocardial Flow Reserve in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (6) ◽  
pp. 1277-1286 ◽  
Author(s):  
Emilie H. Zobel ◽  
Philip Hasbak ◽  
Signe A. Winther ◽  
Christian Stevns Hansen ◽  
Jesper Fleischer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Function ◽  
Myocardial Flow Reserve ◽  
Cardiac Autonomic Function ◽  
Flow Reserve ◽  
Myocardial Flow
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