Albuminuria: Associated With Heart Failure Severity and Impaired Clinical Outcomes

2020 ◽  
Vol 36 (4) ◽  
pp. 527-534 ◽  
Author(s):  
Mony Shuvy ◽  
Donna R. Zwas ◽  
Chaim Lotan ◽  
Andre Keren ◽  
Israel Gotsman
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Failure Severity ◽  
Heart Failure Severity

scholarly journals Inflammation-Related Biomarkers Are Associated with Heart Failure Severity and Poor Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1006
Author(s):  
Ieva Kažukauskienė ◽  
Vaida Baltrūnienė ◽  
Ieva Rinkūnaitė ◽  
Edvardas Žurauskas ◽  
Dalius Vitkus ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Clinical Outcomes ◽  
Interleukin 6 ◽  
Cardiac Event ◽  
Tnf Α ◽  
Failure Severity ◽  
Non Ischemic Dilated Cardiomyopathy ◽  
Hs Crp ◽  
Heart Failure Severity

Inflammation-related biomarkers are associated with clinical outcomes in mixed-etiology chronic heart failure populations. Inflammation-related markers tend to be higher in ischemic than in non-ischemic dilated cardiomyopathy (NI-DCM) patients, which might impact their prognostic performance in NI-DCM patients. Therefore, we aimed to assess the association of inflammation-related biomarkers with heart failure severity parameters and adverse cardiac events in a pure NI-DCM patient cohort. Fifty-seven patients with NI-DCM underwent endomyocardial biopsy. Biopsies were evaluated by immunohistochemistry for CD3+, CD45ro+, CD68+, CD4+, CD54+, and HLA-DR+ cells. Blood samples were tested for high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α (TNF-α), soluble urokinase-type plasminogen activator receptor and adiponectin. During a five-year follow-up, twenty-seven patients experienced at least one composite adverse cardiac event: left ventricle assist device implantation, heart transplantation or death. Interleukin-6, TNF-α and adiponectin correlated with heart failure severity parameters. Patients with higher levels of interleukin-6, TNF-α, adiponectin or hs-CRP, or a higher number of CD3+ or CD45ro+ cells, had lower survival rates. Interleukin-6, adiponectin, and CD45ro+ cells were independently associated with poor clinical outcomes. All patients who had interleukin-6, TNF-α and adiponectin concentrations above the threshold experienced an adverse cardiac event. Therefore, a combination of these cytokines can identify high-risk NI-DCM patients.

Abstract 15684: Discordance Between Severity of Heart Failure as Determined by Patient Report versus Cardiopulmonary Exercise Testing

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Katherine C Michelis ◽  
Justin L Grodin ◽  
Lin Zhong ◽  
Ambarish Pandey ◽  
Kathleen Toto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Patient Reported Outcomes ◽  
Cardiopulmonary Exercise Testing ◽  
Risk Of Death ◽  
Increased Risk ◽  
Patient Reported ◽  
Failure Severity ◽  
Lower Severity ◽  
Heart Failure Severity

Introduction: Although patient-reported outcomes are increasingly emphasized, symptoms may be discordant to objective parameters of heart failure severity. The frequency of such discordance, associated characteristics, and its influence on clinical outcomes is unknown. Methods: This is a post-hoc analysis of the HF-ACTION trial (N=2062). Participants were divided by median baseline values for Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ, subjective measure) and V E /VCO 2 slope (objective measure) into 4 groups: “concordant-lower severity” (high KCCQ, low V E /VCO 2 slope), “concordant-higher severity” (low KCCQ, high V E /VCO 2 slope), “symptom magnifier” (low KCCQ, V E /VCO 2 slope), and “symptom minimizer” (high KCCQ, V E /VCO 2 slope). Baseline characteristics were compared, and the relationship between group and clinical outcomes over a median follow-up of 442 days was assessed in adjusted Cox models. Results: Discordance of patient-reported and objective illness severity was common (46%). Depression was more prevalent among symptom magnifiers (N=480) versus concordant-lower severity (N=566) and symptom minimizer (N=465) groups (30%, 18%, 14%, respectively; P<0.001). Compared to concordant-lower severity participants, those who were symptom magnifiers, symptom minimizers, or concordant-higher severity were at increased risk of hospitalization (Table). Concordant-higher severity participants and symptom minimizers, but not symptom magnifiers, were at an increased risk of death versus concordant-lower severity participants. Conclusion: A high rate of discordance was observed between patient-reported and objective heart failure severity. Depression was associated with symptom magnification. Hospitalization was influenced by patient-reported severity but mortality tracked more closely with objective data, highlighting potential limitations of static patient-reported outcomes for risk stratification.

scholarly journals Raised Sympathetic Nerve Activity in Heart Failure and Central Sleep Apnea Is Due to Heart Failure Severity

Circulation ◽  
2003 ◽  
Vol 107 (10) ◽  
pp. 1396-1400 ◽  
Author(s):  
Darren Mansfield ◽  
David M. Kaye ◽  
Hanspeter Brunner La Rocca ◽  
Peter Solin ◽  
Murray D. Esler ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Central Sleep Apnea ◽  
Nerve Activity ◽  
Failure Severity ◽  
Heart Failure Severity

In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

2018 ◽  
Vol 11 (9) ◽  
pp. e201800066 ◽  
Author(s):  
Evgeny A. Shirshin ◽  
Yury I. Gurfinkel ◽  
Simon T. Matskeplishvili ◽  
Maria L. Sasonko ◽  
Nikolai P. Omelyanenko ◽  
...  
Keyword(s):  
Heart Failure ◽  
Optical Imaging ◽  
Viable Epidermis ◽  
Failure Severity ◽  
In Vivo Optical Imaging ◽  
Heart Failure Severity ◽  
Nailfold Capillaries

Heart Failure Severity Stratification Beyond INTERMACS Profiles

ASAIO Journal ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rebecca Cogswell ◽  
Jerry D. Estep ◽  
Raquel Araujo-Gutierrez ◽  
Maria Masotti ◽  
Valmiki Majaraj ◽  
...  
Keyword(s):  
Heart Failure ◽  
Failure Severity ◽  
Heart Failure Severity

scholarly journals Relationship between clinically assessed heart failure severity and the Tei index in Nigerian patients

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Olarinde Jeffrey Ogunmola ◽  
Anthony Olubunmi Akintomide ◽  
Adeyemi Michael Olamoyegun
Keyword(s):  
Heart Failure ◽  
Tei Index ◽  
Failure Severity ◽  
Heart Failure Severity

Illness Intrusiveness Mediates the Relationship Between Heart Failure Severity and Depression in Older Adults

2011 ◽  
Vol 31 (5) ◽  
pp. 608-621 ◽  
Author(s):  
Ashley W. LeMaire ◽  
Amit Shahane ◽  
Tam K. Dao ◽  
Jeffrey L. Kibler ◽  
Jeffrey A. Cully
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Illness Intrusiveness ◽  
Failure Severity ◽  
The Relationship ◽  
Heart Failure Severity

The effect of glycemic control on heart failure severity in diabetics

2004 ◽  
Vol 10 (4) ◽  
pp. S105 ◽  
Author(s):  
Geetha Bhat ◽  
Margaret Dugan ◽  
Jignesh Shah
Keyword(s):  
Heart Failure ◽  
Glycemic Control ◽  
Failure Severity ◽  
Heart Failure Severity
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