scholarly journals TRACER KINETICS OF FLUORINE-18 LMI1195 COMPARED TO CARBON-11 HYDROXYEPHEDRINE FOR PET IMAGING OF SYMPATHETIC INNERVATION.

2018 ◽  
Vol 34 (10) ◽  
pp. S117-S118 ◽  
Author(s):  
J. Zelt ◽  
J. Renaud ◽  
L. Mielniczuk ◽  
L. Garrard ◽  
C. Orlandi ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Sympathetic Innervation ◽  
Tracer Kinetics ◽  
Kinetics Of

Uptake and tracer kinetics of O-(2-18F-fluoroethyl)-l-tyrosine in meningiomas: preliminary results

2014 ◽  
Vol 42 (3) ◽  
pp. 459-467 ◽  
Author(s):  
Jan F. Cornelius ◽  
Gabriele Stoffels ◽  
Christian Filß ◽  
Norbert Galldiks ◽  
Philipp Slotty ◽  
...  
Keyword(s):  
Tracer Kinetics ◽  
Preliminary Results ◽  
Kinetics Of

F-18 meta-fluorobenzylguanidine PET imaging of myocardial sympathetic innervation

2022 ◽  
Author(s):  
Milan Grkovski ◽  
Pat B. Zanzonico ◽  
Shakeel Modak ◽  
John L. Humm ◽  
Jagat Narula ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Sympathetic Innervation ◽  
Myocardial Sympathetic Innervation

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man

1978 ◽  
Vol 235 (3) ◽  
pp. F254-F264 ◽  
Author(s):  
R. N. Pierson ◽  
D. C. Price ◽  
J. Wang ◽  
R. K. Jain
Keyword(s):  
Compartmental Model ◽  
Human Subjects ◽  
Water Volume ◽  
Tracer Kinetics ◽  
Sucrose Content ◽  
Extracellular Water ◽  
Tracer Injection ◽  
Diffusion Constants ◽  
Specific Organ ◽  
Kinetics Of

Bromide and sucrose distributions were measured as functions of time after tracer injection into 14 rat organs that accounted for 93% of body wt, with the goal of evaluating the use of bromide and sucrose as tracers for the extracellular water volume (ECW). The tracers, Na, 82Br, 125I-labeled human serum albumin, [14C]sucrose, and 3H2O, were used to calculate bromide and sucrose content in red cells, plasma, and 13 blood-free organs. Selective concentration of Br- occurs in RBC, stomach, and skin, accounting in part for the discrepancy between the Br- space and the smaller ECW volume as derived from other methods. Sucrose is rapidly metabolized in the rat and its 14C tracer cannot be used for ECW determination in this species. The kinetics of Br- distribution were estimated in rats and in 16 human subjects by measuring plasma disappearance values and specific organ uptakes. A pharmacokinetic compartmental model was derived, containing explicit parameters for blood flow, diffusion constants, and ECW spaces separately for each organ. Precise fitting of experimental bromide data was achieved for the rat; satisfactory fitting was also achieved in man from more limited plasma and biopsy data.

scholarly journals Correction to: PET imaging of sympathetic innervation with [18F]Flubrobenguane vs [11C]mHED in a patient with ischemic cardiomyopathy

2020 ◽  
Vol 27 (2) ◽  
pp. 702-702
Author(s):  
Jason G. E. Zelt ◽  
Lisa M. Mielniczuk ◽  
Cesare Orlandi ◽  
Simon Robinson ◽  
Tayebeh Hadizad ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Ischemic Cardiomyopathy ◽  
Sympathetic Innervation

PET imaging of sympathetic innervation with [18F]Flurobenguan vs [11C]mHED in a patient with ischemic cardiomyopathy

2018 ◽  
Vol 26 (6) ◽  
pp. 2151-2153 ◽  
Author(s):  
Jason G. E. Zelt ◽  
Lisa M. Mielniczuk ◽  
Cesare Orlandi ◽  
Simon Robinson ◽  
Tayebeh Hadizad ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Ischemic Cardiomyopathy ◽  
Sympathetic Innervation

scholarly journals Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [11C]KR31173

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Nedim C. M. Gulaldi ◽  
Jinsong Xia ◽  
Tao Feng ◽  
Kelvin Hong ◽  
William B. Mathews ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Compartmental Model ◽  
Radioligand Binding ◽  
Left Kidney ◽  
Binding Parameters ◽  
Retention Parameter ◽  
Time Activity ◽  
Kinetics Of

Purpose. The radioligand [11C]KR31173 has been introduced for PET imaging of the angiotensin II subtype 1 receptor (AT1R). The purpose of the present project was to employ and validate a compartmental model for quantification of the kinetics of this radioligand in a porcine model of renal ischemia followed by reperfusion (IR).Procedures. Ten domestic pigs were included in the study: five controls and five experimental animals with IR of the left kidney. To achieve IR, acute ischemia was created with a balloon inserted into the left renal artery and inflated for 60 minutes. Reperfusion was achieved by deflation and removal of the balloon. Blood chemistries, urine specific gravity and PH values, and circulating hormones of the renin angiotensin system were measured and PET imaging was performed one week after IR. Cortical time-activity curves obtained from a 90 min [11C]KR31173 dynamic PET study were processed with a compartmental model that included two tissue compartments connected in parallel. Radioligand binding quantified by radioligand retention (80 min value to maximum value ratio) was compared to the binding parameters derived from the compartmental model. A binding ratio was calculated asDVR=DVS/DVNS, whereDVSandDVNSrepresented the distribution volumes of specific binding and nonspecific binding. Receptor binding was also determined by autoradiographyin vitro.Results. Correlations between rate constants and binding parameters derived by the convolution and deconvolution curve fittings were significant(r>0.9). Also significant was the correlation between the retention parameter derived from the tissue activity curve (Yret) and the retention parameter derived from the impulse response function (fret). Furthermore, significant correlations were found between these two retention parameters and DVR. Measurements with PET showed no significant changes in the radioligand binding parameters caused by IR, and thesein vivofindings were confirmed by autoradiography performedin vitro.Conclusions. Correlations between various binding parameters support the concept of the parallel connectivity compartmental model. If an arterial input function cannot be obtained, simple radioligand retention may be adequate for estimation ofin vivoradioligand binding.

Correlation of myocardial necrosis with kinetics of 111In-labeled myosin-specific antibody in isolated rabbit septum

1991 ◽  
Vol 261 (2) ◽  
pp. H319-H326 ◽  
Author(s):  
B. A. Williams ◽  
S. C. Huang ◽  
J. Krivokapich ◽  
D. B. Buxton ◽  
H. R. Schelbert
Keyword(s):  
Correlation Coefficient ◽  
Myocardial Infarct ◽  
Myocardial Necrosis ◽  
Antibody Fragments ◽  
Tracer Kinetics ◽  
Tissue Necrosis ◽  
Kinetics Of ◽  
Potential Use ◽  
Retention Fraction

Radiolabeled monoclonal antibody fragments to myosin, specifically 111In-labeled antimyosin, have been shown to be effective for imaging areas of myocardial infarct. To determine if 111In-labeled antimyosin can be used to assess the extent of necrosis, we compared the tissue retention fraction of 111In-labeled antimyosin with the amount of creatine kinase (CK) released from the isolated, perfused, interventricular rabbit septum after an intervention to induce tissue necrosis. 111In-labeled antimyosin was injected and tissue radioactivity was monitored for a 60-min period under control conditions. Effluent samples were also collected during this period and assayed for CK content. After a period of Ca2+ depletion followed by Ca2+ repletion, 111In-labeled antimyosin was again injected, and washout and CK data were collected. Comparison of the changes in 111In-labeled antimyosin retention fraction from control to intervention with the corresponding increase in CK released during intervention resulted in a correlation coefficient of 0.83. To corroborate the findings of the Ca2+ depletion followed by repletion experiments, further experiments were conducted in which zero-flow ischemia followed by reperfusion was used as a means of introducing necrosis in the septum. The resulting correlation coefficient between CK release and 111In-labeled antimyosin retention fraction was 0.82. The results of these experiments indicate that 111In-labeled antimyosin can be used to quantitatively estimate the extent of necrosis in the rabbit septum, as determined by CK release, and endorse the potential use of tracer kinetics in humans for quantitation of myocardial necrosis in vivo.

Kinetics of 76Br-labeled anti-CEA antibodies in pigs; Aspects of dosimetry and PET imaging properties

1999 ◽  
Vol 26 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Anna Lövqvist ◽  
Hans Lundqvist ◽  
Mark Lubberink ◽  
Vladimir Tolmachev ◽  
Jörgen Carlsson ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Properties ◽  
Kinetics Of

scholarly journals Impact of Angiogenesis-Related Gene Expression on the Tracer Kinetics of 18F-FDG in Colorectal Tumors

2008 ◽  
Vol 49 (8) ◽  
pp. 1238-1244 ◽  
Author(s):  
L. G. Strauss ◽  
D. Koczan ◽  
S. Klippel ◽  
L. Pan ◽  
C. Cheng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tracer Kinetics ◽  
Colorectal Tumors ◽  
Related Gene ◽  
18F Fdg ◽  
Kinetics Of ◽  
Angiogenesis Related Gene

Tracer kinetics of plants carbon allocation with continuously produced11CO2

1988 ◽  
Vol 124 (1) ◽  
pp. 105-122 ◽  
Author(s):  
Y. Fares ◽  
J. D. Goeschl ◽  
C. E. Magnuson ◽  
H. W. Scheld ◽  
B. R. Strain
Keyword(s):  
Carbon Allocation ◽  
Tracer Kinetics ◽  
Kinetics Of
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