ROLE OF P2Y2R-SRC-FILAMIN A PATHWAY DURING MECHANICAL STRESS-INDUCED MINERALIZATION OF VALVE INTERSTITIAL CELLS: IMPLICATION FOR BICUSPIDE AORTIC VALVE

2016 ◽  
Vol 32 (10) ◽  
pp. S272-S273
Author(s):  
R. Bouchareb ◽  
M. Boulanger ◽  
P. Pibarot ◽  
P. Mathieu ◽  
Y. Bossé
Keyword(s):  
Aortic Valve ◽  
Mechanical Stress ◽  
Interstitial Cells ◽  
Filamin A ◽  
Valve Interstitial Cells

scholarly journals Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Maria Bogdanova ◽  
Aleksandra Kostina ◽  
Katarina Zihlavnikova Enayati ◽  
Arsenii Zabirnyk ◽  
Anna Malashicheva ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Osteogenic Differentiation ◽  
Mechanical Stress ◽  
Interstitial Cells ◽  
Valve Interstitial Cells ◽  
Human Aortic Valve

3D Contractile Responses of Normal and Diseased Human Aortic Valve Interstitial Cells

2021 ◽  
Vol 5 (sup1) ◽  
pp. 1-1
Author(s):  
Alex Khang ◽  
Chiara Camillo ◽  
Giovanni Ferrari ◽  
Michael S. Sacks
Keyword(s):  
Aortic Valve ◽  
Interstitial Cells ◽  
Contractile Responses ◽  
Valve Interstitial Cells ◽  
Human Aortic Valve

scholarly journals Upregulated Autophagy in Calcific Aortic Valve Stenosis Confers Protection of Valvular Interstitial Cells

2019 ◽  
Vol 20 (6) ◽  
pp. 1486 ◽  
Author(s):  
Miguel Carracedo ◽  
Oscar Persson ◽  
Peter Saliba-Gustafsson ◽  
Gonzalo Artiach ◽  
Ewa Ehrenborg ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Interstitial Cells ◽  
Left Ventricular ◽  
Autophagic Flux ◽  
Valvular Interstitial Cells ◽  
Survival Mechanism ◽  
Calcified Tissue ◽  
Left Ventricular Outflow

Autophagy serves as a cell survival mechanism which becomes dysregulated under pathological conditions and aging. Aortic valve thickening and calcification causing left ventricular outflow obstruction is known as calcific aortic valve stenosis (CAVS). CAVS is a chronic and progressive disease which increases in incidence and severity with age. Currently, no medical treatment exists for CAVS, and the role of autophagy in the disease remains largely unexplored. To further understand the role of autophagy in the progression of CAVS, we analyzed expression of key autophagy genes in healthy, thickened, and calcified valve tissue from 55 patients, and compared them with nine patients without significant CAVS, undergoing surgery for aortic regurgitation (AR). This revealed a upregulation in autophagy exclusively in the calcified tissue of CAVS patients. This difference in autophagy between CAVS and AR was explored by LC3 lipidation in valvular interstitial cells (VICs), revealing an upregulation in autophagic flux in CAVS patients. Inhibition of autophagy by bafilomycin-A1 led to a decrease in VIC survival. Finally, treatment of VICs with high phosphate led to an increase in autophagic activity. In conclusion, our data suggests that autophagy is upregulated in the calcified tissue of CAVS, serving as a compensatory and pro-survival mechanism.

scholarly journals Porcine aortic valve interstitial cells are rich in mesenchymal progenitors

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jan‐Hung Chen ◽  
Cindy Ying Yin Yip ◽  
Eli D. Sone ◽  
Craig A. Simmons
Keyword(s):  
Aortic Valve ◽  
Interstitial Cells ◽  
Valve Interstitial Cells ◽  
Mesenchymal Progenitors

scholarly journals Isolation and culture of rat aortic valve interstitial cells

2015 ◽  
Vol 15 (11) ◽  
pp. 893-896 ◽  
Author(s):  
Huiqiang Chen ◽  
Wei Cui ◽  
Haijuan Hu ◽  
Jing Liu
Keyword(s):  
Aortic Valve ◽  
Interstitial Cells ◽  
Valve Interstitial Cells
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