307 Impact of a single mixed mediterranean-type meal relative to a high-fat meal on metabolic markers and postprandial endothelial function

2011 ◽  
Vol 27 (5) ◽  
pp. S174-S175
Author(s):  
S. Lacroix ◽  
C. Des Rosiers ◽  
M. Gayda ◽  
J. Tardif ◽  
A. Nigam
Keyword(s):  
Endothelial Function ◽  
High Fat ◽  
Metabolic Markers ◽  
Fat Meal

Abstract 530: Impact of a Single Mixed Mediterranean-Type Meal Compared with a High-Saturated Fat Meal on Postprandial Endothelial Function and Metabolic Markers

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Sebastien Lacroix ◽  
Christine Des Rosiers ◽  
Mathieu Gayda ◽  
Anil Nigam
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Saturated Fat ◽  
Random Order ◽  
Flow Mediated Dilation ◽  
Omega 3 ◽  
Metabolic Markers ◽  
Endothelial Impairment ◽  
Artery Flow ◽  
Fat Meal

Background: Endothelial dysfunction is considered a precursor of atherosclerosis and is an independent predictor of cardiovascular events. A high-saturated fat meal (HFM) has been shown to induce postprandial endothelial dysfunction. However, no studies have evaluated the acute endothelial effect of a single mixed Mediterranean-type meal (MMM). Our objective was to evaluate postprandial endothelial and metabolic function in response to a MMM in comparison to an isocaloric HFM. Methods: In this ongoing crossover study, 26 of 28 healthy non-smoking males have completed the research protocol. In random order on two separate days during a 1-week interval, subjects were fed two isocaloric meals after an overnight fast. The MMM (885 kcal) consisted of fresh salmon, almonds and vegetables baked in olive oil providing 51% of total calories from fat (7.87g SFA and 2.29g of omega-3, 2:1 DHA:EPA). The HFM consisted of a McDonald’s sausage, egg and cheese McMuffin and three hashbrowns (858 kcal) providing 58% of total energy from fat (14.78g SFA and no omega-3). Endothelial function was evaluated by measuring brachial artery flow-mediated dilation (%FMD) at baseline and at two (T2) and four (T4) hours postprandial. Results: Mean postprandial %FMD tends to be less impaired following the MMM than the HFM (variation at T4 -0.15±3.6% vs -2.83±3.3% respectively, p<0.1). Postprandial variations of TG and TG/HDL at T4 were also less severe with the MMM than the HFM (p≤0.05) and did not correlate to %FMD variations. When subdividing the population on the basis of the median fasting TG levels (0.90 mmol/L), the HFM led to significant endothelial impairment in the subjects with higher-TG while it had no effect in the low-TG group. Conclusion: Our data suggest that a single MMM exerts less of a deleterious effect on postprandial endothelial function and metabolic markers than does a HFM. A single MMM could thus be less atherogenic than a HFM. Moreover, subjects with higher fasting TG levels (avg. 1.54±0.59 mmol/L, well bellow hypertriglyceridemia threshold) could be at higher risk of endothelial injury following a single HFM. Data on all 28 subjects will be available in April 2012.

scholarly journals Acute Effect of High-Fat Meal on Endothelial Function in Moderately Dyslipidemic Subjects

2005 ◽  
Vol 25 (2) ◽  
pp. 406-410 ◽  
Author(s):  
C. Giannattasio ◽  
A. Zoppo ◽  
G. Gentile ◽  
M. Failla ◽  
A. Capra ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Acute Effect ◽  
High Fat ◽  
Fat Meal

The Effect of a High-Fat Meal on Endothelial Function in Physically Active Versus Sedentary Adults

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S84 ◽  
Author(s):  
Jaume Padilla ◽  
Ryan A. Harris ◽  
Kevin P. Hanlon ◽  
Shelby S. Sutton ◽  
Alyce D. Fly ◽  
...  
Keyword(s):  
Endothelial Function ◽  
High Fat ◽  
Physically Active ◽  
Fat Meal

BH4 improves postprandial endothelial function after a high-fat meal in men and postmenopausal women

2017 ◽  
Vol 24 (5) ◽  
pp. 555-562 ◽  
Author(s):  
Yashesh Shah ◽  
Leon Bass ◽  
Gareth W. Davison ◽  
Nichole Seigler ◽  
Jennifer S. Pollock ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Postmenopausal Women ◽  
High Fat ◽  
Fat Meal

scholarly journals Study Protocol: A 2-Month Cross-Over Controlled Feeding Trial Investigating the Effect of Animal and Plant Protein Intake on the Metabolome and Cardiometabolic Health

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1281-1281
Author(s):  
Gaïa Lépine ◽  
François Mariotti ◽  
Jean-François Huneau ◽  
Nathalie Poupin ◽  
Marie Tremblay-Franco ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Plant Protein ◽  
Metabolic Phenotype ◽  
Cardiometabolic Health ◽  
High Fat ◽  
Feeding Trial ◽  
Dietary Shift ◽  
Inflammatory Status ◽  
Fasted State ◽  
Fat Meal

Abstract Objectives A dietary shift in favor of plant protein (PP) sources over animal protein (AP) sources has been advocated for both sustainability and health reasons, this dietary transition being noticeably associated to decreased cardiovascular and diabetes risks. The differences in amino acid composition between PP and AP may have several effects on the metabolic pathways, and in turn health impacts, which are still poorly characterized. This project aims at characterizing, with a combination of “omics” approaches, the metabolic reorientations induced by a dietary shift from AP to PP sources and understanding their health effects in a population at cardiometabolic risk. Methods We will conduct a cross-over randomized feeding trial (NCT04236518) in 20 healthy overweight males (BMI 25–35), aged 25–55, with an enlarged waist circumference (&gt; 94cm) and high plasma triglycerides (&gt;1.5g/L). Participants will be assigned for 1 month each to 2 diets containing predominantly either AP (65% AP:35% PP) or PP (35% AP:65% PP) in a randomized order, separated by a 2-week wash-out period. Lunch and diner will be directly provided while dietary guidelines will be given for breakfast and snacks. Blood, urine and stool samples will be collected at the fasted state every 2 weeks. At the end of each dietary intervention, blood and urine will be collected following a high fat meal, which challenges metabolism and vascular homeostasis. Plasma and urine non-targeted metabolomics analyses (LC-MS) will be combined with Peripheral Blood Mononuclear Cell (PBMC) transcriptomics and fluxomics analyses (D2O tracer) to get a comprehensive overview of the metabolic phenotype associated with AP or PP intake. Flow-Mediated Dilatation (FMD) and Flow Laser Doppler (FLD) will be used to measure respectively macrovascular endothelial function and microvascular skin blood flow at the fasted state and after the high-fat meal. We will also measure anthropometric parameters and analyze biochemistry and inflammatory markers. Results Not applicable (protocols abstract). Conclusions We expect the multi-omics fingerprinting to reveal subtle metabolic differences associated to AP or PP intake, with a positive effect of PP intake. Improved inflammatory status and endothelial function are also expected to be associated to PP intake. Funding Sources INRAE and Roquette Frères.

Impairment of endothelial function after a high-fat meal in patients with coronary artery disease

2001 ◽  
Vol 12 (7) ◽  
pp. 561-565 ◽  
Author(s):  
Shui-Ping Zhao ◽  
Ling Liu ◽  
Mei Gao ◽  
Qi-Chang Zhou ◽  
Yu-Ling Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
High Fat ◽  
Artery Disease ◽  
Fat Meal

A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation

2006 ◽  
Vol 110 (3) ◽  
pp. 387-392 ◽  
Author(s):  
Jaume Padilla ◽  
Ryan A. Harris ◽  
Alyce D. Fly ◽  
Lawrence D. Rink ◽  
Janet P. Wallace
Keyword(s):  
Endothelial Function ◽  
Brachial Artery ◽  
Repeated Measures ◽  
Reactive Hyperaemia ◽  
High Fat ◽  
Low Fat ◽  
Balanced Design ◽  
Treatment Conditions ◽  
Main Effects ◽  
Fat Meal

The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response to an active hyperaemic stimulus is unknown. The purpose of the present study was to compare brachial artery vasodilation in response to an active compared with a reactive hyperaemic stimulus following a known perturbation of endothelial function. Eight apparently healthy adults were assigned to four treatment conditions in a counter-balanced design: (i) low-fat meal with active hyperaemic stimulus (LFM-A), (ii) high-fat meal with active hyperaemic stimulus (HFM-A), (iii) low-fat meal with reactive hyperaemic stimulus (LFM-R), and (iv) high-fat meal with reactive hyperaemic stimulus (HFM-R). Meals were ingested at 08:00 hours on each treatment day. Brachial artery vasodilation was assessed via ultrasound 4 h after ingestion of each meal. The active hyperaemic stimulus was induced by 5 min of rhythmic handgrip exercise, whereas reactive hyperaemia was induced by 5 min of forearm occlusion. Brachial artery vasodilation was expressed as the percentage change in diameter from baseline to post-active/reactive hyperaemia. Using a 2×2 repeated measures ANOVA, a significant stimulus×meal interaction (P=0.025) was found. Simple main effects revealed no difference (P=0.541) in brachial artery vasodilation between LFM-A (5.75±1.64%) and HFM-A (6.39±1.45%); however, a significant decrease (P=0.014) in brachial artery vasodilation was found in the HFM-R (4.29±1.64%) compared with the LFM-R (7.18±1.13%) treatment. In conclusion, the measurement of brachial artery vasodilation in response to active hyperaemia did not detect a change in endothelial function following a single perturbation meal, whereas reactive hyperaemia did.

The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal

2010 ◽  
Vol 35 (3) ◽  
pp. 294-302 ◽  
Author(s):  
Christopher A. Fahs ◽  
Huimin Yan ◽  
Sushant Ranadive ◽  
Lindy M. Rossow ◽  
Stamatis Agiovlasitis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Endothelial Function ◽  
Fish Oil ◽  
Brachial Artery ◽  
Omega 3 ◽  
High Fat ◽  
Time Interaction ◽  
Artery Stiffness ◽  
Fish Oil Supplementation ◽  
Fat Meal

This study examined whether a commercially available fish-oil supplement offers protection from the acute effects of a high-fat meal (HFM) on endothelial function and arterial stiffness. An HFM causes acute impairments in endothelial function, whereas the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have a variety of cardioprotective effects. However, little is known about the efficacy of moderate fish-oil supplementation on the endothelial dysfunction induced by an HFM. Endothelial function (brachial artery flow-mediated dilation (FMD)), forearm blood flow (FBF), total hyperemia, central and peripheral blood pressure, and central artery stiffness were assessed in 20 healthy men (n = 10) and women (n = 10) at rest and 4 h after an HFM supplemented with either placebo or ∼1 g EPA and DHA. Brachial artery FMD normalized for shear rate was significantly impaired (p = 0.033) following the HFM with placebo but remained unchanged compared with baseline following the HFM with the fish-oil supplement (p = 0.039; condition × time interaction). Resting FBF (p = 0.020) and total hyperemia (p = 0.014) were elevated following the HFM. All other vascular and hemodynamic measurements were unchanged in both trials. Commercially available fish-oil supplements taken with an HFM appear to preserve endothelial function following an HFM.

scholarly journals Vitamin C preserves endothelial function in patients with coronary heart disease after a high-fat meal

2002 ◽  
Vol 25 (5) ◽  
pp. 219-224 ◽  
Author(s):  
Ling Liu ◽  
Shui-Ping Zhao ◽  
Mei Gao ◽  
Qi-Chang Zhou ◽  
Yu-Ling Li ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Vitamin C ◽  
Endothelial Function ◽  
High Fat ◽  
Fat Meal

The effect of acute exercise on endothelial function following a high-fat meal

2006 ◽  
Vol 98 (3) ◽  
pp. 256-262 ◽  
Author(s):  
Jaume Padilla ◽  
Ryan A. Harris ◽  
Alyce D. Fly ◽  
Lawrence D. Rink ◽  
Janet P. Wallace
Keyword(s):  
Endothelial Function ◽  
Acute Exercise ◽  
High Fat ◽  
Fat Meal
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