Headspace gas chromatographic method for determining volatile compounds in infant formulas

2004 ◽  
Vol 1046 (1-2) ◽  
pp. 235-239 ◽  
Author(s):  
M Romeu-Nadal ◽  
A.I Castellote ◽  
M.C López-Sabater
Keyword(s):  
Volatile Compounds ◽  
Chromatographic Method ◽  
Infant Formulas ◽  
Headspace Gas ◽  
Gas Chromatographic Method

Aromatic Volatile Composition of Celery and Celeriac Cultivars

HortScience ◽  
1990 ◽  
Vol 25 (5) ◽  
pp. 556-559 ◽  
Author(s):  
Fredy Van Wassenhove ◽  
Patrick Dirinck ◽  
Georges Vulsteke ◽  
Niceas Schamp
Keyword(s):  
Volatile Compounds ◽  
Chromatographic Method ◽  
Apium Graveolens ◽  
Volatile Components ◽  
Two Dimensional ◽  
Qualitative Composition ◽  
Volatile Composition ◽  
Wide Range ◽  
Gas Chromatographic Method ◽  
Identification And Quantification

A two-dimensional capillary gas chromatographic method was developed to separate and quantify aromatic volatiles of celery in one analysis. The isolation, identification, and quantification of the volatile compounds of four cultivars of blanching celery (Apium graveolens L. var. dulce) and six cultivars of celeriac (Apium graveolens L. var. rapaceum) are described. The qualitative composition of Likens-Nickerson extracts of both cultivars is similar. The concentration of terpenes and phthalides, the key volatile components, found in various cultivars of both celery and celeriac varied over a wide range.

A Headspace Gas Chromatographic Method for Determination of Formic acid Content in Isosulfan Blue and in Various Drugs

2021 ◽  
Vol 37 (2) ◽  
pp. 321-329
Author(s):  
Nilesh Takale ◽  
Neelakandan Kaliyaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Rajarajan Govindasamy
Keyword(s):  
Sulfuric Acid ◽  
Formic Acid ◽  
Chromatographic Method ◽  
Isopropyl Alcohol ◽  
Class Iii ◽  
Drug Substances ◽  
Headspace Gas ◽  
Concentrated Sulfuric Acid ◽  
Gas Chromatographic Method

The Pharmaceutical industry uses formic acid in the manufacturing of various drug substances or API. At the time of manufacturing of API formic acid is use as an oxidizing agent. Formic acid is the simplest carboxylic acid. It also called methanoic acid.Formic acid present in API at high concentrations is very hazardous but in low concentrations is very beneficial. The developed and validated method was short, precise, cost effective and reproducible with FID detector and easy to use. The method is a selective and superficial analytical method for determination of formic acid in different drug substances. We report here the development and validation study of headspace gas chromatographic method to determine formic acid in different drug substances we are reported here. As per this method, the drug sample was dissolved in 0.1% (v/v) of concentrated sulfuric acid in isopropyl alcohol (IPA) in a GC headspace vial and 0.1% (v/v) of concentrated sulfuric acid in isopropyl alcohol used as a diluent. A AB-Inowax capillary column (30 m x 0.32 mm I.D. and 0.5 µm film thickness) was used under gradient conditions with FID. The formic acid peak was well separated from all other solvents that are used in synthesis of particular drug substance. The LOD and LOQof the method for formic acid are 82 ppm and 249 ppm respectively. Formic acid are low toxic class-III solvent as per ICH guideline.

Static Headspace Gas Chromatographic Method for Aldehyde Determination in Crackers

2012 ◽  
Vol 6 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Anamarija I. Mandić ◽  
Ivana J. Sedej ◽  
Marijana B. Sakač ◽  
Aleksandra Č. Mišan
Keyword(s):  
Chromatographic Method ◽  
Static Headspace ◽  
Headspace Gas ◽  
Gas Chromatographic Method ◽  
Aldehyde Determination

scholarly journals Single-Laboratory Validation of a Gas Chromatographic Method of Direct Determination of Volatile Compounds in Spirit Drinks: Need for an Improved Interlaboratory Study

2019 ◽  
Vol 102 (2) ◽  
pp. 669-672 ◽  
Author(s):  
Siarhei V Charapitsa ◽  
Svetlana N Sytova ◽  
Anton L Korban ◽  
Lidia N Sobolenko
Keyword(s):  
Volatile Compounds ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Direct Determination ◽  
Relative Bias ◽  
Interlaboratory Study ◽  
Detector Response ◽  
Gas Chromatographic Method ◽  
Single Laboratory

Abstract Background: The quality and safety control of an alcoholic drink is mainly the establishment of its chemical content, particularly the quantity of volatile compounds. Objective: A single-laboratory validation of a gas chromatographic method of direct determination of volatile compounds in spirit drinks was conducted. The discussed method applies ethanol, the major volatile component of an alcoholic beverage, as an internal standard. Possible algorithms of method validation based on interlaboratory study were proposed and described. Methods: Seven standard solutions of the following volatile compounds were prepared gravimetrically in 40% (v/v) water–ethanol solution: acetaldehyde, methyl acetate,ethyl acetate, methanol, 2-propanol, 1-propanol, isobutanol, 1-butanol, and isoamylol. Each sample wasmeasured with the proposed method 30 times in repeatability conditions. Results: Flame ionization detector response was linearly correlated with assigned concentrations at a range of 2 to5000 mg/L of absolute alcohol (AA) with coefficients of determination (R2)more than 0.995 for all analyzed components. Repeatability (RSDr ≤ 4.5%; RSDr ≤ 2.0%), reproducibility (RSDR ≤ 5.0%; RSDR ≤ 2.0%), and trueness (relative bias ≤ 2.6%; relative bias ≤ 1.4%) were obtained for low (10–25 mg/L AA for methanol and 2–10 for othervolatiles) and high (25–5000 mg/L AA for methanol and 10–5000 for other volatiles) ranges of concentrations, correspondingly. Conclusions: The method increases the reliability of measurements and eliminates manual proceduresof internal standard addition into both calibrationstandard solutions and spirit drinks.

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