Regulation of Neurogenic Airway Inflammation via the Dorsal Vagal Complex in a Guinea Pig Model of Gastroesophageal Reflux

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A26
Author(s):  
Zhe Chen ◽  
Le-jia Sun ◽  
Hui Chen ◽  
Da-chuan Gu ◽  
Wei-tao Zhang ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Guinea Pig ◽  
Airway Inflammation ◽  
Pig Model ◽  
Dorsal Vagal Complex ◽  
Guinea Pig Model

scholarly journals Ceramide: a Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation

2007 ◽  
Vol 324 (2) ◽  
pp. 548-557 ◽  
Author(s):  
Emanuela Masini ◽  
Lucia Giannini ◽  
Silvia Nistri ◽  
Lorenzo Cinci ◽  
Rosanna Mastroianni ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Airway Inflammation ◽  
Pig Model ◽  
Signaling Molecule ◽  
Asthmatic Response ◽  
Allergic Asthmatic ◽  
Guinea Pig Model

scholarly journals Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Loes E. M. Kistemaker ◽  
I. Sophie T. Bos ◽  
Mark H. Menzen ◽  
Harm Maarsingh ◽  
Herman Meurs ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Guinea Pig ◽  
Airway Inflammation ◽  
Pig Model ◽  
Chronic Asthma ◽  
Guinea Pig Model

Aerosolized Polymerized Type I Collagen Reduces Airway Inflammation and Remodelling in a Guinea Pig Model of Allergic Asthma

Lung ◽  
2009 ◽  
Vol 188 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Paola Moreno-Alvarez ◽  
Edgar Sánchez-Guerrero ◽  
Erasmo Martínez-Cordero ◽  
Rogelio Hernández-Pando ◽  
María G. Campos ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Type I Collagen ◽  
Pig Model ◽  
Type I ◽  
Guinea Pig Model

scholarly journals Inhibitory Effect of Sihuangxiechai Decoction on Ovalbumin-Induced Airway Inflammation in Guinea Pigs

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Xue Ping Huang ◽  
En Xue Tao ◽  
Zhan Qin Feng ◽  
Zhao Lu Yang ◽  
Wei Fen Zhang
Keyword(s):  
Guinea Pig ◽  
Airway Inflammation ◽  
Treated Group ◽  
Pig Model ◽  
Interleukin 4 ◽  
Necrosis Factor Alpha ◽  
Cell Counts ◽  
Significant Difference ◽  
Guinea Pig Model ◽  
Asthma Group

The aim of this study was to investigate the effect of sihuangxiechai decoction on asthmatic Guinea pig model which was sensitized by intraperitoneal (i.p.) injection of ovalbumin (OVA) and challenged by OVA inhalation to induce chronic airway inflammation. Differential cell counts of cytospins were performed after staining with Giemsa solution. The quantity of leukocytes and its classification in bronchoalveolar lavage fluid (BALF) and blood were evaluated by blood cell analyzer and microscope. Histological analysis of the lung was performed by hematoxylin and eosin (H&E) staining. The levels of interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF-α) in BALF and serum were detected by radioimmunoassay (RIA). The total number of leukocytes in BALF and blood has no significant difference between Sihuangxiechaitang decoction treated group and dexamethasone (DXM) treated group but was significantly lower than those of asthma group. The percentage of eosinophils in lung tissues of sihuangxiechai decoction treated group was significantly lower than that of asthma group. The results demonstrated that the levels of IL-4 and TNF-αin the sihuangxiechai decoction treated group were significantly reduced compared with the asthma group. In conclusion, these findings demonstrate that sihuangxiechai decoction has a protective effect on OVA-induced asthma in reducing airway inflammation and airway hyperresponsiveness (AHR) in a Guinea pig model and may be useful as an adjuvant therapy for the treatment of bronchial asthma.

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