The influence of granule density on granule strength and resulting compact strength

2012 ◽  
Vol 72 ◽  
pp. 205-213 ◽  
Author(s):  
Kevin A. Macias ◽  
M. Teresa Carvajal
Keyword(s):  
Granule Density ◽  
Granule Strength ◽  
Compact Strength

scholarly journals Rab3D regulates amylase levels, not agonist-induced amylase release, in AR42J cells

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
Saima Limi ◽  
George Ojakian ◽  
Robert Raffaniello
Keyword(s):  
Secretory Granules ◽  
Active Form ◽  
Subcellular Fractionation ◽  
Amylase Release ◽  
Ar42j Cells ◽  
Granule Density ◽  
Granule Morphology ◽  
Pancreatic Exocrine

AbstractRab3D is a low molecular weight GTP-binding protein that associates with secretory granules in exocrine cells. AR42J cells are derived from rat pancreatic exocrine tumor cells and develop an acinar cell-like phenotype when treated with dexamethasone (Dex). In the present study, we examined the role of Rab3D in Dex-treated AR42J cells. Rab3D expression and localization were analyzed by subcellular fractionation and immunoblotting. The role of Rab3D was examined by overexpressing myc-labeled wild-type-Rab3D and a constitutively active form of Rab3D (Rab3D-Q81L) in AR42J cells. We found that Rab3D is predominantly membrane-associated in AR42J cells and co-localizes with zymogen granules (ZG). Following CCK-8-induced exocytosis, amylase-positive ZGs appeared to move towards the periphery of the cell and co-localization between Rab3D and amylase was less complete when compared to basal conditions. Overexpression of WT, but not mutant Rab3D, resulted in an increase in cellular amylase levels. Overexpression of mutant and WT Rab3D did not affect granule morphology, CCK-8-induced secretion, long-term (48 hr) basal amylase release or granule density. We conclude that Rab3D is not involved in agonist-induced exocytosis in AR42J cells. Instead, Rab3D may regulate amylase content in these cells.

Influence of Different Suspension Properties on Internal Structure and Deformation Behavior of Spray Dried Ceramic Granules

2010 ◽  
Vol 62 ◽  
pp. 157-162
Author(s):  
Susanna Eckhard ◽  
Manfred Fries
Keyword(s):  
Mechanical Properties ◽  
Image Analysis ◽  
Nitric Acid ◽  
Cross Sections ◽  
Deformation Behavior ◽  
Shell Thickness ◽  
Structure Parameters ◽  
Spray Dryer ◽  
Granule Strength ◽  
Spray Dried

Three different batches of ceramic alumina granules were produced using a spray dryer in laboratory scale. The suspensions containing identical solid contents and amounts of binders were modified by adding nitric acid to get different stabilized conditions. The granules were analyzed concerning micro and macro structural properties by image analysis on specially prepared granule cross-sections. The investigated structure parameters were correlated with the studied mechanical properties using a commercially granule strength tester. Different measured fracture forces were explained by varied macro structures (parameter H, amount of hollow and homogeneous granules and average shell thickness) as a result of modified suspension properties.

scholarly journals New Methods to Resisting Punching Shear Stress in Reinforced Concrete Flat Slabs

2018 ◽  
Vol 8 (02) ◽  
Author(s):  
Fatma M. Eid ◽  
Tayel Magdy ◽  
Ebada Ahmed
Keyword(s):  
Reinforced Concrete ◽  
Shear Failure ◽  
Shear Capacity ◽  
Punching Shear ◽  
Shear Reinforcement ◽  
Reinforcement System ◽  
Strength Concrete ◽  
Flat Slabs ◽  
The Difference ◽  
Compact Strength

Punching shear failure is a major problem encountered in the design of reinforced concrete flat slabs. The utilization of shear reinforcement via shear studs or other means has become a choice for improving the punching shear capacity. In this study, a new alternative of reinforcement modalities were tested and demonstrated the effect of self-compact concrete on the punching shear capacity, beside that compared between the difference codes to identify the suitable one for determining the position of critical section of punching shear. Nevertheless, in this investigation, the proposed reinforcement system is examined for interior columns only. An experimental work consisting of six specimens: five of them were cast with normal reinforced concrete and one was cast with self-compact strength concrete. The obtained results indicate that the proposed shear reinforcement system has a positive effect in the enhancement of the punching shear capacity of interior slab–column connection of self-compact strength concrete.

scholarly journals PRODUCTION OF LIME-AMMONIUM NITRATE BASED ON CHALK, NITRATE AND AMMONIUM SULFATE

2021 ◽  
Vol 2021 (1) ◽  
pp. 5-11
Author(s):  
O Rasulov ◽  
◽  
A Mamataliyev ◽  
M Dadaxodjaeva ◽  
Sh Namazov ◽  
...  
Keyword(s):  
Ammonium Nitrate ◽  
Ammonium Sulfate ◽  
Mass Ratio ◽  
Granule Strength ◽  
Carbonate Melt

The article studies the process of obtaining carbonate-ammonium nitrate (CAN) based on the mixing of melt ammonium nitrate (NH4NO3) with chalk (СаСО3) and ammonium sulfate (NH4)2SO4). For the granulation of nitrate-sulfate-carbonate melt the prilling method is applied using a granulation tower. Determined the composition and properties of new types of fertilizers. It is shown that with the ratio NH4NO3 : СаСО3 : (NH4)2SO4 = 100 : 24 : 1 the product contains 28,03% N, SO3 – 0,50%, 10% СаО and has a granule strength of 6,03 MPa, which is much higher than the strength of pure NH4NO3 granules (1,32 MPa). Porosity and absorption of pure AN granules is 22,0% and 4,82 g. With an increase in the proportion of chalk and ammonium sulfate to the NH4NO3 : СаСО3 : (NH4)2SO4 = 100 : 24 : 1 ratio, the porosity and absorbency of the LAN granules is 6,11% and 2,57g, respectively. It was revealed that the use of the (NH4)2SO4, СаСО3 additive in the NH4NO3 melt at a mass ratio of NH4NO3 : СаСО3 : (NH4)2SO4 = from 100 : 2 : 0,5 to 100 : 58 : 2 allows to increase the strength and temperature of the onset of decomposition of the nitrate granules by 2-6,7 and 1-1,3 times and reduce the porosity by 2,7-4,8 2 times.

scholarly journals Resisting punching shear stress in reinforced concrete slabs

2018 ◽  
Vol 162 ◽  
pp. 04025
Author(s):  
Ebada Ahmed ◽  
Boshra Eltaly ◽  
Fatma El-Zhraa ◽  
Magdy Tayel
Keyword(s):  
Reinforced Concrete ◽  
Shear Failure ◽  
Shear Capacity ◽  
Punching Shear ◽  
Shear Reinforcement ◽  
Reinforcement System ◽  
Strength Concrete ◽  
Reinforced Concrete Slabs ◽  
The Difference ◽  
Compact Strength

Punching shear failure is a major problem encountered in the design of reinforced concrete flat slabs. The utilization of shear reinforcement via shear studs or other means has become a choice for improving the punching shear capacity. In this study, a new alternative of reinforcement modalities were tested and demonstrated the effect of self-compact concrete on the punching shear capacity, beside that compared between the difference codes to identify the suitable one for determining the position of critical section of punching shear. Nevertheless, in this investigation, the proposed reinforcement system is examined for interior columns only. An experimental work consisting of six specimens: five of them were cast with normal reinforced concrete and one was cast with self-compact strength concrete. The obtained results indicate that the proposed shear reinforcement system has a positive effect in the enhancement of the punching shear capacity of interior slab–column connection of self-compact strength concrete.

scholarly journals Effect of Granule Strength on Compressed Tablet Strength.

1995 ◽  
Vol 43 (12) ◽  
pp. 2261-2263 ◽  
Author(s):  
Eijiro HORISAWA ◽  
Akio KOMURA ◽  
Kazumi DANJO ◽  
Akinobu OTSUKA
Keyword(s):  
Tablet Strength ◽  
Granule Strength

Granule Strength as a Formulation Factor I: Instrumentation

1971 ◽  
Vol 60 (6) ◽  
pp. 922-925 ◽  
Author(s):  
Gerald Gold ◽  
Ronald N. Duvall ◽  
Blaze T. Palermo ◽  
Richard L. Hurtle
Keyword(s):  
Factor I ◽  
Granule Strength

Immunohistochemical Localization of ACTH and Prolactin in the Pituitary Gland of Adult Migratory Sockeye Salmon (Oncorhynchus nerka)

1969 ◽  
Vol 26 (7) ◽  
pp. 1837-1846 ◽  
Author(s):  
B. A. McKeown ◽  
A. P. van Overbeeke
Keyword(s):  
Sockeye Salmon ◽  
Fluorescein Isothiocyanate ◽  
Cell Types ◽  
Pituitary Hormones ◽  
Immunohistochemical Localization ◽  
Granule Density ◽  
Pituitary Glands ◽  
Antibody Complex ◽  
Ovine Prolactin ◽  
Antigen Antibody

Antibodies to porcine adrenocorticotrophic hormone (ACTH), Synacthen (synthetic corticotrophin, Ciba), and ovine prolactin were prepared in rabbits and the antisera were tested for specificity against several pituitary hormones. The gamma-globulin fractions of the antisera were conjugated with fluorescein isothiocyanate and the labelled antibodies were "purified" by column chromatography.Fresh-frozen sections of pituitary glands of adult migratory sockeye salmon were incubated with the antibody solutions and examined with a fluorescence microscope. The resulting antigen–antibody complex could be localized by re-photographing the same or alternate sections after fixation and staining. Anti-ACTH and anti-Synacthen appeared to be bound specifically by the epsilon cells, whereas anti-prolactin reacted with the eta cells of the rostral pars distalis. Pituitary glands collected at various stations along the migratory route, including one seawater sample, showed the same reactivity. Other glands were prepared for histological examination. Microspectrophotometric analysis of cell types showed that the granule density of the ACTH cells increased gradually during the later part of migration. In the prolactin cells, no change in granulation could be detected during entrance into the river or subsequent spawning migration.

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