scholarly journals The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

Cell Reports ◽  
2020 ◽  
Vol 33 (3) ◽  
pp. 108295
Author(s):  
Kathrin Landgraf ◽  
Nora Klöting ◽  
Martin Gericke ◽  
Nitzan Maixner ◽  
Esther Guiu-Jurado ◽  
...  
Keyword(s):  
Susceptibility Gene ◽  
Obesity Susceptibility

scholarly journals Relationship of FTO gene variations with NAFLD risk in Chinese men

2020 ◽  
Vol 15 (1) ◽  
pp. 860-867
Author(s):  
Xuefen Chen ◽  
Yong Gao ◽  
Xiaobo Yang ◽  
Haiying Zhang ◽  
Zengnan Mo ◽  
...  
Keyword(s):  
Susceptibility Gene ◽  
Nucleotide Polymorphisms ◽  
Male Population ◽  
Single Nucleotide ◽  
Unadjusted Odds Ratio ◽  
Nonalcoholic Fatty Liver ◽  
Obesity Susceptibility ◽  
Matched Case ◽  
Relationship Of ◽  
Chinese Male

AbstractBackgroundFat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aims to investigate the relationships of FTO gene variations with NAFLD risk in a Chinese male population.MethodsA 1:2 matched case–control study was performed on 275 cases of NAFLD and 550 controls matched for age. Nine of the FTO gene single nucleotide polymorphisms (SNPs) were genotyped.ResultsLogistic regression analysis found that FTO rs1477196 was significantly associated with the susceptibility to NAFLD in recessive genetic models [unadjusted odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.22–5.19, P = 0.012] and the relativity weakened after further adjustment for body mass index (BMI), uric acid, metabolic syndrome, smoking, and drinking (adjusted OR = 2.18, 95% CI: 0.96–4.99, P = 0.06). In the obese group, the AA + AG genotypes of rs1121980 and rs9940128 were associated with a decreased risk of NAFLD, when compared with the GG genotype, respectively (rs1121980: adjusted OR = 0.62, 95% CI = 0.39–0.99, P = 0.044; rs9940128: adjusted OR = 0.61, 95% CI = 0.38–0.97, P = 0.038). Furthermore, rs1477196 was associated with the severity of NAFLD (OR = 2.95, 95% CI = 1.09–7.94, P = 0.034).ConclusionsOur results demonstrated that the FTO gene was related to the presence and severity of NAFLD in a Chinese male population, and the relationships of the tested SNPs with NAFLD are most probably mediated by BMI.

scholarly journals 111The cardiometabolic consequences of obesity susceptibility gene variants in severe obesity

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
S Fenk ◽  
S Mueller ◽  
S Wallner ◽  
C Strack ◽  
U Hubauer ◽  
...  
Keyword(s):  
Severe Obesity ◽  
Susceptibility Gene ◽  
Gene Variants ◽  
Obesity Susceptibility ◽  
Consequences Of Obesity

scholarly journals Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157850 ◽  
Author(s):  
Yamit Bar-Lev ◽  
Sharon Moshitch-Moshkovitz ◽  
Galia Tsarfaty ◽  
Dafna Kaufman ◽  
Judith Horev ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Transgenic Mice ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Susceptibility Gene ◽  
Obesity Susceptibility

scholarly journals The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

2009 ◽  
Vol 15 (10) ◽  
pp. 1195-1201 ◽  
Author(s):  
Leona Plum ◽  
Hua V Lin ◽  
Roxanne Dutia ◽  
Jun Tanaka ◽  
Kumiko S Aizawa ◽  
...  
Keyword(s):  
Food Intake ◽  
Susceptibility Gene ◽  
Obesity Susceptibility

scholarly journals Establishing a Role for Sarcospan as an Obesity‐Susceptibility Gene in Mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Aaron Matthews ◽  
Isela Valera ◽  
Rhiannon Crawford ◽  
Salma Elsheikh ◽  
Hyun Hwang ◽  
...  
Keyword(s):  
Susceptibility Gene ◽  
Obesity Susceptibility
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