scholarly journals Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

Cell Reports ◽  
2020 ◽  
Vol 32 (11) ◽  
pp. 108151
Author(s):  
Ke Chen ◽  
Xuanmao Jiao ◽  
Agnese Di Rocco ◽  
Duanwen Shen ◽  
Shaohua Xu ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mitogenic Signaling

scholarly journals IKKα Regulates Mitogenic Signaling through Transcriptional Induction of Cyclin D1 via Tcf

2003 ◽  
Vol 14 (2) ◽  
pp. 585-599 ◽  
Author(s):  
Chris Albanese ◽  
Kongming Wu ◽  
Mark D'Amico ◽  
Christy Jarrett ◽  
David Joyce ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Cyclin D1 ◽  
Target Genes ◽  
Cell Cycle Control ◽  
S Phase ◽  
Mitogenic Signaling ◽  
Iκb Kinase ◽  
Transcriptional Induction ◽  
Phase Entry

The Wnt/β-catenin/Tcf and IκB/NF-κB cascades are independent pathways involved in cell cycle control, cellular differentiation, and inflammation. Constitutive Wnt/β-catenin signaling occurs in certain cancers from mutation of components of the pathway and from activating growth factor receptors, including RON and MET. The resulting accumulation of cytoplasmic and nuclear β-catenin interacts with the Tcf/LEF transcription factors to induce target genes. The IκB kinase complex (IKK) that phosphorylates IκB contains IKKα, IKKβ, and IKKγ. Here we show that the cyclin D1 gene functions as a point of convergence between the Wnt/β-catenin and IκB pathways in mitogenic signaling. Mitogenic induction of G1-S phase progression and cyclin D1 expression was PI3K dependent, and cyclin D1 −/− cells showed reduced PI3K-dependent S-phase entry. PI3K-dependent induction of cyclin D1 was blocked by inhibitors of PI3K/Akt/IκB/IKKα or β-catenin signaling. A single Tcf site in the cyclin D1 promoter was required for induction by PI3K or IKKα. In IKKα −/− cells, mitogen-induced DNA synthesis, and expression of Tcf-responsive genes was reduced. Reintroduction of IKKα restored normal mitogen induction of cyclin D1 through a Tcf site. In IKKα −/− cells, β-catenin phosphorylation was decreased and purified IKKα was sufficient for phosphorylation of β-catenin through its N-terminus in vitro. Because IKKα but not IKKβ induced cyclin D1 expression through Tcf activity, these studies indicate that the relative levels of IKKα and IKKβ may alter their substrate and signaling specificities to regulate mitogen-induced DNA synthesis through distinct mechanisms.

scholarly journals Cyclin D1, p16, and retinoblastoma gene regulate mitogenic signaling of endothelin in rat mesangial cells

1998 ◽  
Vol 53 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Yoshio Terada ◽  
Seiji Inoshita ◽  
Osamu Nakashima ◽  
Takehisa Yamada ◽  
Mimi Tamamori ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mesangial Cells ◽  
Retinoblastoma Gene ◽  
Mitogenic Signaling

805: High-Level Cyclin D1 is Associated with High Gleason Grade and Predicts Worse Biochemical-Free Survival in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Rile Li ◽  
Hong Dai ◽  
Thomas M. Wheeler ◽  
Anna Frolov ◽  
Gustavo Ayala
Keyword(s):  
Prostate Cancer ◽  
Cyclin D1 ◽  
Gleason Grade ◽  
Free Survival ◽  
High Level

Expression of histone H3, p53, cyclin D1, and cyclin B1 in oral mucosal lesions

2009 ◽  
Vol 13 (4) ◽  
pp. 119-126
Author(s):  
Yoshimitsu Bamba ◽  
Tetsunari Nishikawa ◽  
Akio Tanaka
Keyword(s):  
Cyclin D1 ◽  
Histone H3 ◽  
Cyclin B1 ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Cyclin D1 levels are involved in the resistance to m-TOR inhibitors in human bronchial carcinoids

2014 ◽  
Author(s):  
Katiuscia Benfini ◽  
Teresa Gagliano ◽  
Erica Gentilin ◽  
Mariella Minoia ◽  
Mole Daniela ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Bronchial Carcinoids
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