scholarly journals Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Cell Reports ◽  
2020 ◽  
Vol 32 (2) ◽  
pp. 107905 ◽  
Author(s):  
Patrycja Kozik ◽  
Marine Gros ◽  
Daniel N. Itzhak ◽  
Leonel Joannas ◽  
Sandrine Heurtebise-Chrétien ◽  
...  
Keyword(s):  
Tumor Immunity ◽  
Small Molecule ◽  
Small Molecule Enhancers

scholarly journals Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Kyle R. Simonetta ◽  
Joshua Taygerly ◽  
Kathleen Boyle ◽  
Stephen E. Basham ◽  
Chris Padovani ◽  
...  
Keyword(s):  
Small Molecule ◽  
E3 Ligase ◽  
Substrate Interaction ◽  
Small Molecule Enhancers

scholarly journals Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death

2013 ◽  
Vol 8 (5) ◽  
pp. 923-929 ◽  
Author(s):  
Drew J. Adams ◽  
Zarko V. Boskovic ◽  
Jimmy R. Theriault ◽  
Alex J. Wang ◽  
Andrew M. Stern ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Small Molecule ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Small Molecule Enhancers

scholarly journals Small Molecule Enhancers of Rapamycin-Induced TOR Inhibition Promote Autophagy, Reduce Toxicity in Huntington’s Disease Models and Enhance Killing of Mycobacteria by Macrophages

Autophagy ◽  
2007 ◽  
Vol 3 (6) ◽  
pp. 620-622 ◽  
Author(s):  
R. Andres Floto ◽  
Sovan Sarkar ◽  
Ethan O. Perlstein ◽  
Beate Kampmann ◽  
Stuart L. Schreiber ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Small Molecule ◽  
Disease Models ◽  
Small Molecule Enhancers

scholarly journals Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

2015 ◽  
Vol 112 (31) ◽  
pp. E4281-E4287 ◽  
Author(s):  
Szu-Yu Kuo ◽  
Adam B. Castoreno ◽  
Leslie N. Aldrich ◽  
Kara G. Lassen ◽  
Gautam Goel ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cytokine Production ◽  
Human Genetics ◽  
Diversity Oriented Synthesis ◽  
Inflammatory Cytokine Production ◽  
Disease Phenotypes ◽  
Small Molecule Probes ◽  
Bacterial Replication ◽  
Small Molecule Enhancers

Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here, we describe the discovery of the small-molecule probe BRD5631 that is derived from diversity-oriented synthesis and enhances autophagy through an mTOR-independent pathway. We demonstrate that BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.

High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression

2017 ◽  
Vol 33 (6) ◽  
pp. 1579-1588 ◽  
Author(s):  
Hermann-Josef Meyer ◽  
Rebecca Turincio ◽  
Shirley Ng ◽  
Juan Li ◽  
Blair Wilson ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Expression ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Screening ◽  
Transient Protein Expression ◽  
Small Molecule Enhancers

Identification of novel small molecule enhancers of protein production by cultured mammalian cells

2008 ◽  
Vol 100 (6) ◽  
pp. 1193-1204 ◽  
Author(s):  
Martin J. Allen ◽  
James P. Boyce ◽  
Michael T. Trentalange ◽  
David L. Treiber ◽  
Brian Rasmussen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Mammalian Cells ◽  
Protein Production ◽  
Small Molecule Enhancers

Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy

2019 ◽  
Author(s):  
Meghana M Kulkarni ◽  
Timothy Dwight ◽  
Kristen Marino ◽  
Bryce K Allen ◽  
Mohammed Taimi ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Tumor Immunity ◽  
Small Molecule
Sign in / Sign up

Export Citation Format

Share Document