scholarly journals Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain

Cell Reports ◽  
2020 ◽  
Vol 31 (11) ◽  
pp. 107777
Author(s):  
Peter Androvic ◽  
Denisa Kirdajova ◽  
Jana Tureckova ◽  
Daniel Zucha ◽  
Eva Rohlova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Brain ◽  
Transcriptional Response ◽  
Aged Mouse ◽  
Stroke In Young

scholarly journals Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

2019 ◽  
Author(s):  
Peter Androvic ◽  
Denisa Belov Kirdajova ◽  
Jana Tureckova ◽  
Daniel Zucha ◽  
Eva Rohlova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Expression Analysis ◽  
Temporal Dynamics ◽  
Age Groups ◽  
Transcriptional Response ◽  
Cell Types ◽  
Selective Vulnerability ◽  
Type I ◽  
Aged Mouse ◽  
Age Related

AbstractIschemic stroke is one of the leading causes of mortality and major healthcare and economic burden. It is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we performed a comprehensive RNA-Seq analysis of aging, ischemic stroke and their interaction using a model of permanent middle cerebral artery occlusion (MCAO) in 3 and 18 month old female mice. We assessed differential gene expression across injury status and age, estimated cell type proportion changes, assayed the results against a range of transcriptional signatures from the literature and performed unsupervised co-expression analysis, identifying modules of genes with varying response to injury. We uncovered selective vulnerability of neuronal populations and increased activation of type-I interferon (IFN-I) signaling and several other inflammatory pathways in aged mice. We extended these findings via targeted expression analysis in tissue as well as acutely purified cellular populations to show differential temporal dynamics of IFN-I signaling between age groups and contribution of individual cell types. Together, these results paint a picture of ischemic stroke as a complex age-related disease and provide insights into interaction of aging and stroke on cellular and molecular level.Graphical summary

Risk Factor and Etiology Analysis of Ischemic Stroke in Young Adult Patients

2014 ◽  
Vol 23 (3) ◽  
pp. e221-e227 ◽  
Author(s):  
Rosaria Renna ◽  
Fabio Pilato ◽  
Paolo Profice ◽  
Giacomo Della Marca ◽  
Aldobrando Broccolini ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Young Adult ◽  
Adult Patients ◽  
Stroke In Young

The involvement of the factor V G1691A gene on recurrent ischemic stroke in young adults

2021 ◽  
Vol 429 ◽  
pp. 118692
Author(s):  
Lamia Mbarek ◽  
Salma Sakka ◽  
Fatma Megdich ◽  
Khadija Sonda Moalla ◽  
Nadia Bouattour ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Factor V ◽  
Stroke In Young Adults ◽  
Factor V G1691a ◽  
Stroke In Young

Abstract WMP53: Traditional Vascular Risk Factors Account for Different Proportions of Ischemic Stroke Within Different Gender and Race Groups

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Elizabeth M Aradine ◽  
Yan Hou ◽  
Kathleen A Ryan ◽  
Prachi Mehndiratta ◽  
Michael S Phipps ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Ischemic Stroke ◽  
Black Men ◽  
White Men ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Odds Ratios ◽  
Stroke In Young Adults ◽  
Stroke In Young

Introduction: Few studies have compared the proportion of ischemic strokes attributable to traditional vascular risk factors (population-attributable risk percent or PAR%) between genders and races. The PAR% is a function of the population prevalence and strength of association of a risk factor. Methods: A population-based case-control study of ischemic stroke in young adults ages 18-49 in the Baltimore-Washington region was used to study the prevalence, odds ratios, and PAR% of hypertension, diabetes, and smoking among blacks and whites. Logistic regression was used to calculate age-adjusted odds ratios. All analyses were stratified by gender. Results: There were 1044 cases and 1099 controls. Of the cases, 47% were black, 54% were women. Roughly a quarter to a third of all strokes in women were attributable to smoking. Due to the higher prevalence of hypertension and a higher odds ratio for hypertension in black men (OR 3.9, 95% CI 2.6-5.9) compared to white men (OR 1.8, 95% CI 1.3-2.6), there was a much higher PAR% for hypertension among black men than white men. See Table 1 for prevalence and Table 2 for PAR% stratified by gender and race. Conclusion: Traditional vascular risk factors have the potential to explain a high proportion of ischemic stroke in young adults. The high proportion of strokes in women attributable to smoking underscores the need for targeted smoking cessation interventions in this population. Diabetes and, especially, hypertension are important contributors to the excess population burden of ischemic stroke among blacks. These findings support the value of early screening and treatment for hypertension in young blacks.

Epidemiology and Etiology of Ischemic Stroke in Young Adults Aged 18 to 44 Years in Northern Sweden

Stroke ◽  
1997 ◽  
Vol 28 (9) ◽  
pp. 1702-1709 ◽  
Author(s):  
Bo Kristensen ◽  
Jan Malm ◽  
Bo Carlberg ◽  
Birgitta Stegmayr ◽  
Christer Backman ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Northern Sweden ◽  
Stroke In Young Adults ◽  
Stroke In Young

scholarly journals Focal Cerebral Arteriopathy in Young Adult Patients With Stroke

Stroke ◽  
2020 ◽  
Vol 51 (5) ◽  
pp. 1596-1599
Author(s):  
Mary Clare McKenna ◽  
Noel Fanning ◽  
Simon Cronin
Keyword(s):  
Ischemic Stroke ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Arterial Ischemic Stroke ◽  
Tertiary Referral Center ◽  
Stroke In Young Adults ◽  
Distal Internal Carotid Artery ◽  
Cerebral Arteriopathy ◽  
Stroke In Young

Background and Purpose— Focal cerebral arteriopathy is monophasic inflammatory stenosis of the distal internal carotid artery or the proximal segment of the middle cerebral artery. It is one of the most common causes of acute arterial ischemic stroke in young children but is a less familiar entity for adult neurologists. Methods— We retrospectively reviewed stroke service radiology records at a tertiary referral center from January 2013 to December 2014. Focal cerebral arteriopathy was defined as nonprogressive unifocal and unilateral stenosis/irregularity of the distal internal carotid artery or its proximal branches. Only patients aged 16 to 55 years with stroke were included. Results— There were 5 cases of focal cerebral arteriopathy: 2 males and 3 females. Three cases were from the cohort of 123 acute presentations of young stroke, and 2 cases were outpatient referrals. The mean age (range) was 43 (32–55) years. The majority presented with recurrent transient ischemic attacks/minor strokes within a single vascular territory over days to weeks. All cases had characteristic radiological features. Interval imaging demonstrated resolution in 1 case and improvement in 3 cases. Functional outcome was excellent with discharge modified Rankin Scale score ranging from 0 to 1. Recurrence occurred in 1 case. Conclusions— Focal cerebral arteriopathy is a rare cause of arterial ischemic stroke in young adults. Follow-up intracranial imaging is essential to differentiate from progressive arteriopathies. Evidence-based treatment warrants further investigation. Prognosis is favorable.

scholarly journals Macrophage Migration Inhibitory Factor Alters Functional Properties of CA1 Hippocampal Neurons in Mouse Brain Slices

2019 ◽  
Vol 21 (1) ◽  
pp. 276 ◽  
Author(s):  
Eric Bancroft ◽  
Rahul Srinivasan ◽  
Lee A. Shapiro
Keyword(s):  
Ischemic Stroke ◽  
Mouse Brain ◽  
Migration Inhibitory Factor ◽  
Hippocampal Neurons ◽  
Macrophage Migration Inhibitory Factor ◽  
Hippocampal Slices ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Cns Injury ◽  
Neuronal Function

Neuroinflammation is implicated in a host of neurological insults, such as traumatic brain injury (TBI), ischemic stroke, Alzheimer’s disease, Parkinson’s disease, and epilepsy. The immune response to central nervous system (CNS) injury involves sequelae including the release of numerous cytokines and chemokines. Macrophage migration inhibitory factor (MIF), is one such cytokine that is elevated following CNS injury, and is associated with the prognosis of TBI, and ischemic stroke. MIF has been identified in astrocytes and neurons, and some of the trophic actions of MIF have been related to its direct and indirect actions on astrocytes. However, the potential modulation of CNS neuronal function by MIF has not yet been explored. This study tests the hypothesis that MIF can directly influence hippocampal neuronal function. MIF was microinjected into the hippocampus and the genetically encoded calcium indicator, GCaMP6f, was used to measure Ca2+ events in acute adult mouse brain hippocampal slices. Results demonstrated that a single injection of 200 ng MIF into the hippocampus significantly increased baseline calcium signals in CA1 pyramidal neuron somata, and altered calcium responses to N-methyl-d-aspartate (NMDA) + D-serine in pyramidal cell apical dendrites located in the stratum radiatum. These data are the first to show direct effects of MIF on hippocampal neurons and on NMDA receptor function. Considering that MIF is elevated after brain insults such as TBI, the data suggest that, in addition to the previously described role of MIF in astrocyte reactivity, elevated MIF can have significant effects on neuronal function in the hippocampus.

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