scholarly journals Antigen levels of coagulation factor XII, coagulation factor XI and prekallikrein, and the risk of myocardial infarction and ischemic stroke in young women

2014 ◽  
Vol 12 (5) ◽  
pp. 606-613 ◽  
Author(s):  
B. Siegerink ◽  
F. R. Rosendaal ◽  
A. Algra
Keyword(s):  
Myocardial Infarction ◽  
Ischemic Stroke ◽  
Young Women ◽  
Coagulation Factor ◽  
Factor Xii ◽  
Factor Xi ◽  
Stroke In Young

Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women

2002 ◽  
Vol 116 (2) ◽  
pp. 376-382 ◽  
Author(s):  
Alexander P. Reiner ◽  
Michele B. Frank ◽  
Stephen M. Schwartz ◽  
Michael L. Linenberger ◽  
W. T. Longstreth ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ischaemic Stroke ◽  
Young Women ◽  
Factor Xiii ◽  
Coagulation Factor ◽  
Coagulation Factor Xiii ◽  
Stroke In Young

scholarly journals Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women

2015 ◽  
Vol 13 (9) ◽  
pp. 1568-1575 ◽  
Author(s):  
B. Siegerink ◽  
A. Maino ◽  
A. Algra ◽  
F. R. Rosendaal
Keyword(s):  
Myocardial Infarction ◽  
Ischemic Stroke ◽  
Young Women ◽  
Stroke In Young

scholarly journals ASSOCIATION OF BODY MASS INDEX WITH RISKS OF MYOCARDIAL INFARCTION AND ISCHEMIC STROKE IN YOUNG WOMEN: A NATIONWIDE STUDY

2013 ◽  
Vol 61 (10) ◽  
pp. E32
Author(s):  
Michelle Dalgas Schmiegelow ◽  
Charlotte Andersson ◽  
Kober Lars ◽  
Soren Skott Andersen ◽  
Jonas B. Olesen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Body Mass Index ◽  
Ischemic Stroke ◽  
Body Mass ◽  
Young Women ◽  
Nationwide Study ◽  
Stroke In Young

Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke

Blood ◽  
2008 ◽  
Vol 111 (3) ◽  
pp. 1282-1286 ◽  
Author(s):  
D. Martijn O. Pruissen ◽  
Arjen J. C. Slooter ◽  
Frits R. Rosendaal ◽  
Yolanda van der Graaf ◽  
Ale Algra
Keyword(s):  
Ischemic Stroke ◽  
Oral Contraceptive ◽  
Confidence Interval ◽  
Young Women ◽  
Odds Ratio ◽  
Factor Xiii ◽  
Contraceptive Use ◽  
Coagulation Factor ◽  
Oral Contraceptive Use ◽  
Stroke In Young

Abstract Prothrombotic conditions are associated with ischemic stroke in young women. In particular, the combination of oral contraceptive use and prothrombotic genetic variants appears to increase the risk of ischemic stroke. We performed a population-based case-control study in 190 women aged 20 to 49 years with ischemic stroke and 767 women without cardiovascular disease stratified for age, calendar year of the index event, and residence. A total of 4 variants of coagulation factor XIII subunit A and B genes (F13A1 and F13B) were investigated. The Phe allele of the F13A1 Tyr204Phe variant was present in 59 (31%) patients and 43 (6%) controls; the odds ratio for ischemic stroke was 9.1 for Phe/Phe and Phe/Tyr versus Tyr/Tyr genotype; the 95% confidence interval was 5.5 to 15. Homozygous genotypes (Phe/Phe) conferred a higher risk (odds ratio, 77; 95% confidence interval, 7.0-848) than heterozygous (Tyr/Phe) genotypes (odds ratio, 8.2; 95% confidence interval, 4.9-14). The risk of ischemic stroke was further increased in carriers of the 204Phe allele using oral contraceptives (odds ratio, 20; 95% confidence interval, 9-46) compared with nonusers with Tyr/Tyr genotype. In conclusion, the F13A1 204Phe allele was strongly associated with ischemic stroke in young women. Oral contraceptive use further increased the risk of ischemic stroke.

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation

2017 ◽  
Vol 117 (08) ◽  
pp. 1601-1614 ◽  
Author(s):  
Ingrid Stroo ◽  
Sacha Zeerleder ◽  
Chao Ding ◽  
Brenda Luken ◽  
Joris Roelofs ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Klebsiella Pneumoniae ◽  
Inflammatory Responses ◽  
Coagulation Factor ◽  
Host Defence ◽  
Human Neutrophils ◽  
Factor Xii ◽  
Factor Xi ◽  
Phagocytic Capacity ◽  
Bacterial Outgrowth

SummaryBacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence during pneumonia and whether this is dependent on FXII activation, we infected in parallel wild-type (WT), FXI knockout (KO) and FXII KO mice with two different clinically relevant pathogens, the Gram-positive bacterium Streptococcus pneumoniae and the Gram-negative bacterium Klebsiella pneumoniae, via the airways. FXI deficiency worsened survival and enhanced bacterial outgrowth in both pneumonia models. This was accompanied with enhanced inflammatory responses in FXI KO mice. FXII KO mice were comparable with WT mice in Streptococcus pneumoniae pneumonia. On the contrary, FXII deficiency improved survival and reduced bacterial outgrowth following infection with Klebsiella pneumoniae. In both pneumonia models, local coagulation was not impaired in either FXI KO or FXII KO mice. The capacity to phagocytose bacteria was impaired in FXI KO neutrophils and in human neutrophils where activation of FXI was inhibited. Deficiency for FXII or blocking activation of FXI via FXIIa had no effect on phagocytosis. Taken together, these data suggest that FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa.Supplementary Material to this article is available online at www.thrombosis-online.com.

scholarly journals Genetic Variants of Coagulation Factor XI Show Association with Ischemic Stroke Up to 70 Years of Age

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75286 ◽  
Author(s):  
Ellen Hanson ◽  
Staffan Nilsson ◽  
Katarina Jood ◽  
Bo Norrving ◽  
Gunnar Engström ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Coagulation Factor ◽  
Factor Xi

scholarly journals COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke

2010 ◽  
Vol 2 (1) ◽  
pp. 5 ◽  
Author(s):  
Peter Kraft ◽  
Tobias Schwarz ◽  
Lionel Pochet ◽  
Guido Stoll ◽  
Christoph Kleinschnitz
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Coagulation Factor ◽  
Factor Xii

Lipoprotein (a) and the risk of ischemic stroke in young women

2000 ◽  
Vol 150 (2) ◽  
pp. 389-396 ◽  
Author(s):  
Robert J. Wityk ◽  
Steven J. Kittner ◽  
Jennifer L. Jenner ◽  
J.Richard Hebel ◽  
Anne Epstein ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Young Women ◽  
Lipoprotein A ◽  
Stroke In Young
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